Skip to main content
SpringerLink
Log in

Preparation, properties, and drug release of thermo- and pH-sensitive poly((2-dimethylamino)ethyl methacrylate)/poly(N,N-diethylacrylamide) semi-IPN hydrogels

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

In this paper, a series of semi-interpenetrating polymer network (semi-IPN) hydrogels based on poly((2-dimethylamino)ethyl methacrylate)/poly (N,N-diethylacrylamide) (PDMAEMA/PDEA) were synthesized by changing the initial PDMAEMA/DEA molar ratio at room temperature. The influence of this additive on the property of resulting PDEA hydrogels was investigated and characterized. The interior morphology by scanning electron microscopy (SEM) revealed that the semi-IPN hydrogels have interconnected porous network structures. The glass transition temperature (T g) of the semi-IPN hydrogels was observed by differential scanning calorimetry (DSC). Equilibrium swelling ratio (ESR), swelling and deswelling dynamics of the hydrogels responding to temperature and pH were investigated in detail. Compared to PDEA, the semi-IPN hydrogels exhibited excellent mutative values in response to an alternation of the temperature and pH, and showed fast swelling and deswelling rates in response to temperature and pH change. The release behaviors of the model drug, aminophylline, were found dependent on hydrogel compositions and environmental temperature. These results suggest that the stimuli semi-IPN hydrogel have potential application as intelligent drug carriers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Gil ES, Hudson SM (2004) Prog Polym Sci 29:1173

    Article  CAS  Google Scholar 

  2. Geever LM, Minguez CM, Devine DM, Nugent MJD, Kennedy JE, Hanley A, Higginbotham CL (2007) J Mater Sci 42:4136. doi:10.1007/s10853-006-0912-z

    Article  CAS  Google Scholar 

  3. Irie M, Miyatake O, Uchida K (1992) J Am Chem Soc 114:8715

    Article  CAS  Google Scholar 

  4. Sousa A, Maria DA, Sousa RG, Sousa EMB (2010) J Mater Sci 45:1478. doi:10.1007/s10853-009-4106-3

    Article  Google Scholar 

  5. Chen J, Liu MZ, Chen W, Zhang NY, Zhu SY, Zhang SP, Xiong Y (2010) J Biomater Sci Polymer Edn. doi:10.1163/092050610X498196

  6. Hoffman AS (2002) Adv Drug Deliv Rev 54:3

    Article  CAS  Google Scholar 

  7. Shibanuma T, Aoki T, Sanui K, Ogata N, Kikuchi A, Sakurai V, Okano T (2000) Macromolecules 33:444

    Article  CAS  Google Scholar 

  8. Chen J, Liu MZ, Chen SL (2009) Mater Chem Phys 115:339

    Article  CAS  Google Scholar 

  9. Traitel T, Cohen Y, Kost J (2000) Biomaterials 21:1679

    Article  CAS  Google Scholar 

  10. Basan H, Gümüsderelíoglu M, Orbey T (2002) Int J Pharm 245:191

    Article  CAS  Google Scholar 

  11. Lee WF, Lin YH (2006) J Mater Sci 41:7333. doi:10.1007/s10853-006-0882-1

    Article  CAS  Google Scholar 

  12. Zhang XZ, Yang YY, Chung TS (2002) Langmuir 18:2538

    Article  CAS  Google Scholar 

  13. Wu XS, Hoffman AS, Yager P (1992) J Polym Sci A 30:2121

    Article  CAS  Google Scholar 

  14. Li X, Zhang XZ, Chu YF, Xu XD, Cheng SX, Zhuo RX, Wang QR (2006) Eur Polym J 42:2458

    Article  CAS  Google Scholar 

  15. Yin L, Fei L, Cui F, Tang C, Yin C (2007) Biomaterials 28:1258

    Article  CAS  Google Scholar 

  16. Lipatov YS (2002) Prog Polym Sci 27:1721

    Article  CAS  Google Scholar 

  17. Sperling LH, Mishra V (1996) Polymeric materials encyclopedia. CRC Press, Boca Raton

    Google Scholar 

  18. Zhao Q, Sun JZ, Ling QC, Zhou QY (2009) Langmuir 25:3249

    Article  CAS  Google Scholar 

  19. Hoare TR, Kohane DS (2008) Polymer 49:1993

    Article  CAS  Google Scholar 

  20. Chen SL, Liu MZ, Jin SP, Chen Y (2005) J Appl Polym Sci 98:1720

    Article  CAS  Google Scholar 

  21. Brazel CS, Peppas NA (1999) Polymer 40:3383

    Article  CAS  Google Scholar 

  22. Zhang JT, Bhat R, Jandt KD (2009) Acta Biomater 5:488

    Article  CAS  Google Scholar 

  23. Jin L, Deng YH, Hu JH, Wang CC (2004) J Polym Sci A 42:6081

    Article  CAS  Google Scholar 

  24. Zhao Q, Sun JZ, Ren H, Zhou QY, Lin QC (2008) J Polym Sci A 46:2222

    Article  CAS  Google Scholar 

  25. Idziak I, Avoce D, Lessard D, Gravel D, Zhu XX (1999) Macromolecules 32:1260

    Article  CAS  Google Scholar 

  26. Wander D, Wickramasinghe SR, Hussona SM (2010) J Memb Sci 357:6

    Article  Google Scholar 

  27. Zhang Y, Xu L, Yi M, Zhai M, Wang J, Ha H (2006) Eur Polym J 42:2959

    Article  CAS  Google Scholar 

  28. Mazied NA, Ismail SA, Taleb MFA (2009) Radiat Phys chem 78:899

    Article  CAS  Google Scholar 

  29. González-Sáiz JM, Fernández-Torroba MA, Pizarro C (1997) Eur Polym J 33:475

    Article  Google Scholar 

  30. Hariharan D, Peppas NA (1996) Polymer 37:149

    Article  CAS  Google Scholar 

  31. Alfrey T, Gurnee EF, Lloyd WG (1966) J Polym Sci Polym Symp 12:249

    Google Scholar 

  32. Wang ZC, Xu XD, Chen CS, Wang GR, Wang B, Zhang XZ, Zhuo RX (2008) Colloid Surf B 67:245

    Article  CAS  Google Scholar 

  33. Liu HL, Liu MZ, Ma LW, Chen J (2009) Eur Polym J 45:2060

    Article  CAS  Google Scholar 

  34. Luo YL, Zhang KP, Wei QB, Liu ZQ, Chen YS (2009) Acta Biomater 5:316

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge the financial support of the Special Doctorial Program Fund of the Ministry of Education of China (Grant No. 20090211110004) and Gansu Province Project of Science and Technologies (Grant No. 0804WCGA130).

Author information

Authors and Affiliations

  1. State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, 730000, People’s Republic of China

    Naiyan Zhang, Mingzhu Liu, Jun Chen & Chunmei Gao

  2. PLA Command Academy of Engineer Corps, Xuzhou, 221004, People’s Republic of China

    Naiyan Zhang, Yueguo Shen & Liangliang Dai

  3. Engineering Institute of Corps of Engineers, PLA University of Science and Technology, Nanjing, 210007, People’s Republic of China

    Yueguo Shen

  4. Kunming Fire Command School, Kunming, 650208, People’s Republic of China

    Jun Chen

Authors
  1. Naiyan Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mingzhu Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yueguo Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jun Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Liangliang Dai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chunmei Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mingzhu Liu.

Electronic supplementary material

Below is the link to the electronic supplementary material.

10853_2010_4957_MOESM1_ESM.tif

SEM images of the PDEA and the semi-IPN3 hydrogel: a PDEA hydrogel, b drug loaded PDEA hydrogel, c semi-IPN3 hydrogel, d drug loaded semi-IPN3 hydrogel (TIFF 3370 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, N., Liu, M., Shen, Y. et al. Preparation, properties, and drug release of thermo- and pH-sensitive poly((2-dimethylamino)ethyl methacrylate)/poly(N,N-diethylacrylamide) semi-IPN hydrogels. J Mater Sci 46, 1523–1534 (2011). https://doi.org/10.1007/s10853-010-4957-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-010-4957-7

Keywords

Search

Navigation