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Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions

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Abstract

Bone mineral of human is different in composition from the stoichiometric hydroxyapatite (Ca10(PO4)6(OH)2) in that it contains additional ions, of which CO 2−3 is the most abundant species. Carbonate-substituted hydroxyapatite (CHA) bodies were prepared by the hydrothermal treatment of highly porous calcium carbonate (CaCO3) body at 120 °C in 1 M M2HPO4 and M3PO4 solutions (M = NH4 or K). It was found that CaCO3 body was almost transformed into CHA body after hydrothermal treatment for 24 h irrespective of type of phosphate solution. However, a small amount of CaCO3 still remained after the treatment in K3PO4 for 48 h. Crystal shape of CHA bodies prepared in those solutions except for K2HPO4 was flake-like, which was different from that (stick-like) of original CaCO3 body used for the preparation of CHA body. CHA prepared in the K2HPO4 showed globule-like crystal. Average pore size and hole size of the CHA bodies were 150, 70 μm and their porosities were about 89% irrespective of the solution. Carbonate content was slightly higher in the CHA bodies obtained from potassium phosphate solutions than in those obtained from ammonium phosphate solutions. Mostly B-type CHA was obtained after the hydrothermal treatment in the potassium phosphate solutions. On the other hand, mixed A- and B-type CHA (ca. 1–2 in molar ratio) was obtained in the ammonium phosphate solutions. The content of CO 2−3 in the CHA body depended on the type of phosphate solution and was slightly larger in the potassium phosphate solutions.

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Acknowledgements

This study was supported in part by a Grant-in-aid for Scientific Research from the Ministry of Education, Sports, Culture, Science, and Technology, Japan

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Authors and Affiliations

  1. Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-3-1 Maidashi, Higashiku, Fukuoka, 812-8582, Japan

    Yoong Lee, Shigeki Matsuya, Masaharu Nakagawa & Kunio Ishikawa

  2. Department of Chemical Engineering, College of Engineering, Dankook University, Seoul, 140-714, Korea

    Yoong Lee & Yeong Min Hahm

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  1. Yoong Lee
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  2. Yeong Min Hahm
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  3. Shigeki Matsuya
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  4. Masaharu Nakagawa
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Correspondence to Yoong Lee.

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Lee, Y., Hahm, Y.M., Matsuya, S. et al. Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions. J Mater Sci 42, 7843–7849 (2007). https://doi.org/10.1007/s10853-007-1629-3

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  • DOI: https://doi.org/10.1007/s10853-007-1629-3

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