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Chemical conjugation with cyclodextrins as a versatile tool for drug delivery

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Abstract

Cyclodextrins (CDs) are a well-known family of macrocyclic oligosaccharides consisted of α-(1, 4) linked glucose subunits, and have been generally used as mimetic enzymes, chiral reagents, sensors, excipients and drug delivery carriers, due to their hydrophobic and optically active interiors. A more recent interest focuses on the chemical conjugation of CDs with drugs, where a drug is covalently bonded to CDs with better physicochemical properties for controlled drug delivery. This contribution outlines the potential applications of the drug-CDs conjugates in different areas of drug delivery, particularly in peptides, proteins, and nucleic acids (DNA, RNA and gene) drug delivery. Finally, the future directions of research in this field are proposed.

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Acknowledgements

We would like to express sincere thanks to Mr. S. Wei, and Dr. X. Fu, School of Pharmacy, Ningxia Medical University, for their good advice, warm support and kind help. We thank Ms. B. Tian, Ms. T. Zhao, Ms. P. Ma, Ms. S. Luo, School of Pharmacy, Ningxia Medical University, for their excellent contribution to this study. This work was partially supported by the National Natural Science Foundation of China (Nos. 21506104, 21666031), which are gratefully acknowledged.

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  1. Hui Min Chu and Rui Xia Zhang have contributed equally to this work, and are joint first authors.

Authors and Affiliations

  1. School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China

    Hui Min Chu, Rui Xia Zhang, Qing Huang, Chang Cai Bai & Zhi Zhong Wang

  2. Department of Pharmacy, The Third People’s Hospital of Yinchuan, Yinchuan, 750004, China

    Rui Xia Zhang

  3. Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Yinchuan, 750004, China

    Zhi Zhong Wang

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  1. Hui Min Chu
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Chu, H.M., Zhang, R.X., Huang, Q. et al. Chemical conjugation with cyclodextrins as a versatile tool for drug delivery. J Incl Phenom Macrocycl Chem 89, 29–38 (2017). https://doi.org/10.1007/s10847-017-0743-3

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  • DOI: https://doi.org/10.1007/s10847-017-0743-3

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