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Influence of α- and γ- cyclodextrin lipophilic derivatives on curcumin-loaded SLN

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Abstract

Solid lipid nanoparticles (SLN) made of different triglycerides (TG) in the presence and in the absence of various modified α- and γ-cyclodextrins (CD) were prepared by the solvent injection technique. A new synthesis of lipophilic derivatives of γ- CD was developed in this work. Curcumin (CU), a natural polyphenol with antitumor, antioxidant and anti-inflammatory properties, was used as model drug. SLNs mean sizes were in the 250–800 nm range and afforded CU entrapment efficiency in the 12–85% range. The presence of CD derivatives with almost the same chain length of TG induced an improvement of nanoparticle characteristics decreasing mean size values and increasing CU entrapment efficiency. A significant reduction in CU photodegradation was noted only when the drug was vehicled in tristearin-SLN, which became less pronounced in the presence of CD-derivatives, determining a loss in photoprotection. The hydrolytic stability of curcumin was highly improved by drug loading in tristearin-SLN, and only slightly by loading it in tricaprin-SLN, and this seemed not to be influenced by the presence of CD derivatives. Skin uptake studies revealed an increase in CU skin accumulation when CU was loaded in SLN obtained with all CD derivatives, particularly with most lipophilic one.

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Acknowledgments

This work was supported by a grant from the Italian Government (MIUR, Cofin 2006).

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Authors and Affiliations

  1. Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, via P. Giuria 9, 10125, Torino, Italy

    Daniela Chirio, Marina Gallarate, Michele Trotta, Maria Eugenia Carlotti, Emanuela Calcio Gaudino & Giancarlo Cravotto

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  1. Daniela Chirio
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  2. Marina Gallarate
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  3. Michele Trotta
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  4. Maria Eugenia Carlotti
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  5. Emanuela Calcio Gaudino
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  6. Giancarlo Cravotto
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Correspondence to Marina Gallarate.

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Chirio, D., Gallarate, M., Trotta, M. et al. Influence of α- and γ- cyclodextrin lipophilic derivatives on curcumin-loaded SLN. J Incl Phenom Macrocycl Chem 65, 391–402 (2009). https://doi.org/10.1007/s10847-009-9597-7

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  • DOI: https://doi.org/10.1007/s10847-009-9597-7

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