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Inclusion complexes of Sulconazole with β-cyclodextrin and hydroxypropyl β-cyclodextrin: characterization in aqueous solution and in solid state

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Abstract

Complexation between sulconazole (SULC), an imidazole derivative with in vitro antifungal and antiyeast activity, and β-cyclodextrins (β-CD and HP-β-CD) was studied in solution and in solid states. Complexation in solution was evaluated using solubility studies and nuclear magnetic resonance spectroscopy (1H-NMR). In the solid state, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and RX diffraction studies were used. Solubility studies suggested the existence of inclusion complex between SULC and β-CD or HP-β-CD. 1H-NMR spectroscopy studies showed that the complex formed occurs by complexation of imidazole ring into inner cavity. DSC studies showed the existence of a complex of SULC with β-CD. The TGA and RX studies confirmed the DSC results of the complex. Solubility of SULC in solid complexes was studied by the dissolution method and it was found to be much more soluble than the uncomplexed drug.

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Authors and Affiliations

  1. Inorganic Polymers, Institute of Macromolecular Chemistry Petru Poni, Str. Gr Ghica Voda, no 41 A, Iasi, 711321, Romania

    Mariana Spulber, Mariana Pinteala, Valeria Harbagiu & Bogdan C. Simionescu

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  1. Mariana Spulber
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  2. Mariana Pinteala
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  3. Valeria Harbagiu
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  4. Bogdan C. Simionescu
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Correspondence to Mariana Spulber.

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Spulber, M., Pinteala, M., Harbagiu, V. et al. Inclusion complexes of Sulconazole with β-cyclodextrin and hydroxypropyl β-cyclodextrin: characterization in aqueous solution and in solid state. J Incl Phenom Macrocycl Chem 61, 41–51 (2008). https://doi.org/10.1007/s10847-007-9391-3

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  • DOI: https://doi.org/10.1007/s10847-007-9391-3

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