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Interaction between hydrophilic drug and α-cyclodextrins: physico-chemical aspects

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Abstract

The aim of the study was to evaluate if the complexation of a hydrophilic molecule by cyclodextrins is possible. Cyclodextrins (CDs) are hydrophilic cone shaped molecules, which are used as vehicles able to include organic molecules. Because of the presence of hydroxy groups (OH) outside of the molecule, cyclodextrins are not predisposed to include hydrophilic drugs. They are therefore used to improve the solubility of poor water-soluble molecules. In order to evaluate if the complexation of a hydrophilic molecule by cyclodextrins is possible, lyophilized complexes of cysteamine hydrochloride with α-cyclodextrins (α-CD) have been realized. Six analytical techniques (High performance Liquid Chromatography coupled to UV detection, Thin-Layer Chromatography, Fourier Transform Infrared spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Mass Spectrometry (SM) and Proton Nuclear Magnetic Resonance (NMR-NOESY spectra)) were used in order to characterize the interaction between the drug and the α-CD. The realization of complex between a cyclodextrin and a water-soluble drug seems feasible. In the case of a hydrophilic molecule, the complexation is not obtained by inclusion of the drug in the cyclodextrin, but by binding to the outside of the cone. This “external complexation” is however sufficient to improve some features of the molecule, such as organoleptic features, and to modifiy measurable parameters (FT-IR, DSC, SM and NMR-NOESY spectra).

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Authors and Affiliations

  1. Laboratoire de Pharmacie Galénique, ADEN EA 3234, UFR Médecine et Pharmacie, Université de ROUEN, 22, Bd Gambetta, 76000, Rouen, France

    Malika Lahiani-Skiba, Yannick Boulet, Ibrahima Youm, Fréderic Bounoure, Philippe Arnaud & Mohamed Skiba

  2. Laboratoire de Chimie Analytique, ADEN EA 3234, UFR Médecine et Pharmacie, Université de Rouen, 22, Bd Gambetta, 76000, Rouen, France

    Philippe Vérité

  3. In-Cyclo, UFR Médecine et Pharmacie, Université de Rouen, 22, Bd Gambetta, 76000, Rouen, France

    Fréderic Bounoure

Authors
  1. Malika Lahiani-Skiba
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  2. Yannick Boulet
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  3. Ibrahima Youm
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  4. Fréderic Bounoure
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  5. Philippe Vérité
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  6. Philippe Arnaud
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  7. Mohamed Skiba
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Correspondence to Mohamed Skiba.

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Lahiani-Skiba, M., Boulet, Y., Youm, I. et al. Interaction between hydrophilic drug and α-cyclodextrins: physico-chemical aspects. J Incl Phenom Macrocycl Chem 57, 211–217 (2007). https://doi.org/10.1007/s10847-006-9194-y

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  • DOI: https://doi.org/10.1007/s10847-006-9194-y

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