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The role of the Purkinje network in premature ventricular complex-triggered ventricular fibrillation

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Abstract

The Purkinje network (PN) is the distal part of the ventricular conduction system, which has shown to play a central role in the pathophysiology of ventricular fibrillation (VF). Abnormal automaticity and triggered activity are commonly seen in the PN, and the resulting premature ventricular complexes (PVCs) are frequently recognized as triggers of this life-threatening arrhythmia. Catheter ablation targeting PN-related PVCs can be successfully performed in patients with medically refractory VF in a variety of arrhythmic substrates.

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Authors and Affiliations

  1. Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, 3000 N. IH-35, Suite 720, Austin, TX, 78705, USA

    Carola Gianni, J David Burkhardt, Chintan Trivedi, Sanghamitra Mohanty & Andrea Natale

  2. U.O.C. Cardiologia, IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

    Carola Gianni

  3. Dell Medical School, University of Texas, Austin, TX, USA

    Sanghamitra Mohanty

  4. Interventional Electrophysiology, Scripps Clinic, La Jolla, CA, USA

    Andrea Natale

  5. MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Andrea Natale

  6. Division of Cardiology, Stanford University, Stanford, CA, USA

    Andrea Natale

  7. Electrophysiology and Arrhythmia Services, California Pacific Medical Center, San Francisco, CA, USA

    Andrea Natale

Authors
  1. Carola Gianni
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  2. J David Burkhardt
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  3. Chintan Trivedi
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  4. Sanghamitra Mohanty
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  5. Andrea Natale
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Correspondence to Carola Gianni.

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Gianni, C., Burkhardt, J.D., Trivedi, C. et al. The role of the Purkinje network in premature ventricular complex-triggered ventricular fibrillation. J Interv Card Electrophysiol 52, 375–383 (2018). https://doi.org/10.1007/s10840-018-0402-7

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  • DOI: https://doi.org/10.1007/s10840-018-0402-7

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