Skip to main content
Log in

An unusual case of vancomycin-related systemic reaction accompanied with severe thrombocytopenia mimicking pacemaker-related infective endocarditis: a case report and review of literature

  • Case Reports
  • Published:
Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive resistant bacteria. In recent years, several cases of vancomycin-associated immune thrombocytopenia have been presented as case reports, but the real incidence of this side effect is still unknown. In this report, we would like to present a case during which we confronted with a great dilemma: urgent removal of whole defibrillator system due to highly suspected infective endocarditis or leaving the defibrillator in place and simply switching vancomycin to another antibiotic agent and wait.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Aster, R. H., & Bougie, D. W. (2007). Drug-induced immune thrombocytopenia. The New England Journal of Medicine, 357, 580–587.

    Article  PubMed  Google Scholar 

  2. George, J. N., Raskob, G. E., Shah, S. R., Rizvi, M. A., Hamilton, S. A., Osborne, S., & Vondracek, T. (1998). Drug-induced thrombocytopenia: a systematic review of published case reports. Annals of Internal Medicine, 129, 886–890.

    Article  PubMed  CAS  Google Scholar 

  3. Li, X., Swisher, K. K., Vesely, S. K., & George, J. N. (2007). Drug-induced thrombocytopenia: an updated systematic review, 2006. Drug Safety, 30, 185–6.

    Article  PubMed  Google Scholar 

  4. Kuruppu, J. C., Le, T. P., & Tuazon, C. U. (1999). Vancomycin-associated thrombocytopenia: case report and review of the literature. American Journal of Hematology, 60(3), 249–50.

    Article  PubMed  CAS  Google Scholar 

  5. Govindarajan, R., Baxter, D., Wilson, C., & Zent, C. (1999). Vancomycin-induced thrombocytopenia. American Journal of Hematology, 62(2), 122–3.

    Article  PubMed  CAS  Google Scholar 

  6. Zenon, G. J., Cadle, R. M., & Hamill, R. J. (1991). Vancomycin-induced thrombocytopenia. Archives of Internal Medicine, 151, 995–996.

    Article  PubMed  CAS  Google Scholar 

  7. Mizon, P., Kiefel, V., Mannessier, L., Mueller-Eckhardt, C., & Goudemand, J. (1997). Thrombocytopenia induced by vancomycin dependent platelet antibody. Vox Sanguinis, 73, 49–51.

    Article  PubMed  CAS  Google Scholar 

  8. Von Drygalski, A., Curtis, B. R., Bougie, D. W., McFarland, J. G., Ahl, S., Limbu, I., Baker, K. R., & Aster, R. H. (2007). Vancomycin-induced immune thrombocytopenia. The New England Journal of Medicine, 356, 904–910.

    Article  Google Scholar 

  9. Habib, G., Hoen, B., Tornos, P., et al. (2009). Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. European Heart Journal, 30, 2369–413.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Basar Candemir.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Candemir, B., Aribuca, A., Koca, C. et al. An unusual case of vancomycin-related systemic reaction accompanied with severe thrombocytopenia mimicking pacemaker-related infective endocarditis: a case report and review of literature. J Interv Card Electrophysiol 38, 143–145 (2013). https://doi.org/10.1007/s10840-012-9738-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10840-012-9738-6

Keywords

Navigation