Abstract
Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive resistant bacteria. In recent years, several cases of vancomycin-associated immune thrombocytopenia have been presented as case reports, but the real incidence of this side effect is still unknown. In this report, we would like to present a case during which we confronted with a great dilemma: urgent removal of whole defibrillator system due to highly suspected infective endocarditis or leaving the defibrillator in place and simply switching vancomycin to another antibiotic agent and wait.
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References
Aster, R. H., & Bougie, D. W. (2007). Drug-induced immune thrombocytopenia. The New England Journal of Medicine, 357, 580–587.
George, J. N., Raskob, G. E., Shah, S. R., Rizvi, M. A., Hamilton, S. A., Osborne, S., & Vondracek, T. (1998). Drug-induced thrombocytopenia: a systematic review of published case reports. Annals of Internal Medicine, 129, 886–890.
Li, X., Swisher, K. K., Vesely, S. K., & George, J. N. (2007). Drug-induced thrombocytopenia: an updated systematic review, 2006. Drug Safety, 30, 185–6.
Kuruppu, J. C., Le, T. P., & Tuazon, C. U. (1999). Vancomycin-associated thrombocytopenia: case report and review of the literature. American Journal of Hematology, 60(3), 249–50.
Govindarajan, R., Baxter, D., Wilson, C., & Zent, C. (1999). Vancomycin-induced thrombocytopenia. American Journal of Hematology, 62(2), 122–3.
Zenon, G. J., Cadle, R. M., & Hamill, R. J. (1991). Vancomycin-induced thrombocytopenia. Archives of Internal Medicine, 151, 995–996.
Mizon, P., Kiefel, V., Mannessier, L., Mueller-Eckhardt, C., & Goudemand, J. (1997). Thrombocytopenia induced by vancomycin dependent platelet antibody. Vox Sanguinis, 73, 49–51.
Von Drygalski, A., Curtis, B. R., Bougie, D. W., McFarland, J. G., Ahl, S., Limbu, I., Baker, K. R., & Aster, R. H. (2007). Vancomycin-induced immune thrombocytopenia. The New England Journal of Medicine, 356, 904–910.
Habib, G., Hoen, B., Tornos, P., et al. (2009). Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. European Heart Journal, 30, 2369–413.
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Candemir, B., Aribuca, A., Koca, C. et al. An unusual case of vancomycin-related systemic reaction accompanied with severe thrombocytopenia mimicking pacemaker-related infective endocarditis: a case report and review of literature. J Interv Card Electrophysiol 38, 143–145 (2013). https://doi.org/10.1007/s10840-012-9738-6
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DOI: https://doi.org/10.1007/s10840-012-9738-6