Skip to main content
Log in

Atrial fibrillation: Catheter ablation

  • State of the Art Review
  • Published:
Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Catheter ablation of atrial fibrillation (AF) has evolved dramatically over the last several years. The initial efforts in the catheter-based management of AF targeted the atrial substrate in an effort to mimic the maze procedure. After the pulmonary veins (PV) were shown to be critical in the initiation and perpetuation of AF, the focus then shifted to a trigger approach in which the PVs and other foci were targeted for ablation. The pendulum then appeared to swing back toward the substrate approach after it was shown that left atrial circumferential ablation afforded improved outcomes in patients with paroxysmal and persistent AF. It has become clear that there are several possible approaches in the catheter ablation of AF, each with its strengths and limitations. It is also becoming evident that not all patients will respond to a single ablation technique and that the ablation protocol is best tailored to suit the individual patient. This article strives to present an evidence-based review of the many techniques, and then offer a practical guide to the catheter ablation of AF.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Swartz, J., Perrersels, G., Silvers, J., et al. (1994). A catheter based curative approach to atrial fibrillation in humans. Circulation, 90, I–335, (abstr).

    Google Scholar 

  2. Haissaguerre, M., Jais, P., Shah, D. C., et al. (1998). Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. New England Journal of Medicine, 339, 659–666.

    Article  PubMed  CAS  Google Scholar 

  3. Oral, H., Scharf, C., Chugh, A., et al. (2003). Catheter ablation for paroxysmal atrial fibrillation: Segmental pulmonary vein ostial ablation versus left atrial ablation. Circulation, 108, 2355–2360.

    Article  PubMed  Google Scholar 

  4. Chugh, A., Oral, H., Good, E., et al. (2005). Catheter ablation of atypical atrial flutter and atrial tachycardia within the coronary sinus after left atrial ablation for atrial fibrillation. Journal of the American College of Cardiology, 46, 83–91.

    Article  PubMed  Google Scholar 

  5. Chugh, A., Oral, H., Lemola, K., et al. (2005). Prevalence, mechanisms, and clinical significance of macroreentrant atrial tachycardia during and following left atrial ablation for atrial fibrillation. Heart Rhythm, 2, 464–471.

    Article  PubMed  Google Scholar 

  6. Pappone, C., Oral, H., Santinelli, V., et al. (2004). Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial fibrillation. Circulation, 109, 2724–2726.

    Article  PubMed  Google Scholar 

  7. Ho, S., Cabrera, J., Tran, V., et al. (2001). Architecture of the pulmonary veins: Relevance to radiofrequency ablation. Heart, 86, 265–270.

    Article  PubMed  CAS  Google Scholar 

  8. Saito, T., Waki, K., & Becker, A. (2000). Left atrial myocardial extension onto pulmonary veins in humans: Anatomic observations relevant for atrial arrhythmias. Journal of Cardiovascular Electrophysiology, 11, 888–894.

    PubMed  CAS  Google Scholar 

  9. Hocini, M., Ho, S. Y., Kawara, T., et al. (2002). Electrical conduction in canine pulmonary veins: Electrophysiological and anatomic correlation. Circulation, 105, 2442–2448.

    Article  PubMed  Google Scholar 

  10. Chen, S., Hsieh, M., Tai, C., et al. (1999). Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: Electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. Circulation, 100, 1879–1886.

    PubMed  CAS  Google Scholar 

  11. Jais, P., Hocini, M., Macle, L., et al. (2002). Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation. Circulation, 106, 2479–2485.

    Article  PubMed  Google Scholar 

  12. Kumagai, K., Ogawa, M., Noguchi, H., et al. (2004). Electrophysiologic properties of pulmonary veins assessed using a multielectrode basket catheter. Journal of the American College of Cardiology, 43, 2281–2289.

    Article  PubMed  Google Scholar 

  13. Po, S. S., Li, Y., Tang, D., et al. (2005). Rapid and stable re-entry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation. Journal of the American College of Cardiology, 45, 1871–1877.

    Article  PubMed  Google Scholar 

  14. Ouyang, F., Bansch, D., Ernst, S., et al. (2004). Complete isolation of left atrium surrounding the pulmonary veins: New insights from the double-Lasso technique in paroxysmal atrial fibrillation. Circulation, 110, 2090–2096.

    Article  PubMed  Google Scholar 

  15. Oral, H., & Morady, F. (2004). Ablation of atrial fibrillation. Journal of Cardiovascular Electrophysiology, 15, 112–113.

    Article  PubMed  Google Scholar 

  16. Jalife, J. (2003). Rotors and spiral waves in atrial fibrillation. Journal of Cardiovascular Electrophysiology, 14, 776–780.

    Article  PubMed  Google Scholar 

  17. Mandapati, R., Skanes, A., Chen, J., et al. (2000). Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation, 101, 194–199.

    PubMed  CAS  Google Scholar 

  18. Sanders, P., Berenfeld, O., Hocini, M., et al. (2005). Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans. Circulation, 112, 789–797.

    Article  PubMed  Google Scholar 

  19. Lazar, S., Dixit, S., Marchlinski, F. E., et al. (2004). Presence of left-to-right atrial frequency gradient in paroxysmal but not persistent atrial fibrillation in humans. Circulation, 110, 3181–3186.

    Article  PubMed  Google Scholar 

  20. Lin, Y. J., Tai, C. T., Kao, T., et al. (2006). Frequency analysis in different types of paroxysmal atrial fibrillation. Journal of the American College of Cardiology, 47, 1401–1407.

    Article  PubMed  Google Scholar 

  21. Moe, G. (1968). A conceptual model of atrial fibrillation. Journal of Electrocardiology, 1, 145–146.

    Article  PubMed  CAS  Google Scholar 

  22. Oral, H., Knight, B. P., Ozaydin, M., et al. (2002). Segmental ostial ablation to isolate the pulmonary veins during atrial fibrillation: Feasibility and mechanistic insights. Circulation, 106, 1256–1262.

    Article  PubMed  Google Scholar 

  23. Chugh, A., Ozaydin, M., Scharf, C., et al. (2004). Mechanism of immediate recurrences of atrial fibrillation after restoration of sinus rhythm. Pacing and Clinical Electrophysiology, 27, 77–82.

    Article  PubMed  Google Scholar 

  24. Oral, H., Ozaydin, M., Tada, H., et al. (2002). Mechanistic significance of intermittent pulmonary vein tachycardia in patients with atrial fibrillation. Journal of Cardiovascular Electrophysiology, 13, 645–650.

    Article  PubMed  Google Scholar 

  25. Wazni, O. M., Marrouche, N. F., Martin, D. O., et al. (2005). Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: A randomized trial. Jama, 293, 2634–2640.

    Article  PubMed  CAS  Google Scholar 

  26. Oral, H., Pappone, C., Chugh, A., et al. (2006). Circumferential pulmonary-vein ablation for chronic atrial fibrillation. New England Journal of Medicine, 354, 934–941.

    Article  PubMed  CAS  Google Scholar 

  27. Lakkireddy, D., Patel, D., Ryschon, K., et al. (2005). Safety and efficacy of radiofrequency energy catheter ablation of atrial fibrillation in patients with pacemakers and implantable cardiac defibrillators. Heart Rhythm, 2, 1309–1316.

    Article  PubMed  Google Scholar 

  28. Oral, H., Knight, B. P., Tada, H., et al. (2002). Pulmonary vein isolation for paroxysmal and persistent atrial fibrillation. Circulation, 105, 1077–1081.

    Article  PubMed  Google Scholar 

  29. Macle, L., Jais, P., Weerasooriya, R., et al. (2002). Irrigated-tip catheter ablation of pulmonary veins for treatment of atrial fibrillation. Journal of Cardiovascular Electrophysiology, 13, 1067–1073.

    Article  PubMed  Google Scholar 

  30. Hocini, M., Jais, P., Sanders, P., et al. (2005). Techniques, evaluation, and consequences of linear block at the left atrial roof in paroxysmal atrial fibrillation: A prospective randomized study. Circulation, 112, 3688–3696.

    Article  PubMed  Google Scholar 

  31. Hocini, M., Shah, D., Jais, P., et al. (2000). Concealed left pulmonary vein potentials unmasked by left atrial stimulation. Pacing and Clinical Electrophysiology, 23, 1832–1835.

    PubMed  CAS  Google Scholar 

  32. Tada, H., Oral, H., Ozaydin, M., et al. (2002). Response of pulmonary vein potentials to premature stimulation. Journal of Cardiovascular Electrophysiology, 13, 33–37.

    Article  PubMed  Google Scholar 

  33. Oral, H., Knight, B. P., & Morady, F. (2003). Left atrial flutter after segmental ostial radiofrequency catheter ablation for pulmonary vein isolation. Pacing and Clinical Electrophysiology, 26, 1417–1419.

    Article  PubMed  Google Scholar 

  34. Scharf, C., Sneider, M., Case, I., et al. (2003). Anatomy of the pulmonary veins in patients with atrial fibrillation and effects of segmental ostial ablation analyzed by computed tomography. Journal of Cardiovascular Electrophysiology, 14, 150–155.

    Article  PubMed  Google Scholar 

  35. Lin, W., Tai, C., Hsieh, M., et al. (2003). Catheter ablation of paroxysmal atrial fibrillation initiated by non-pulmonary vein ectopy. Circulation, 107, 3176–3183.

    Article  PubMed  Google Scholar 

  36. Pappone, C., Oreto, G., Lamberti, F., et al. (1999). Catheter ablation of paroxysmal atrial fibrillation using a 3D mapping system. Circulation, 100, 1203–1208.

    PubMed  CAS  Google Scholar 

  37. Pappone, C., Oreto, G., Rosanio, S., et al. (2001). Atrial electroanatomic remodeling after circumferential radiofrequency pulmonary vein ablation: Efficacy of an anatomic approach in a large cohort of patients with atrial fibrillation. Circulation, 104, 2539–2544.

    PubMed  CAS  Google Scholar 

  38. Lemola, K., Oral, H., Chugh, A., et al. (2005). Pulmonary vein isolation as an end point for left atrial circumferential ablation of atrial fibrillation. Journal of the American College of Cardiology, 46, 1060–1066.

    Article  PubMed  Google Scholar 

  39. Pappone, C., Santinelli, V., Manguso, F., et al. (2004). Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation, 109, 327–334.

    Article  PubMed  Google Scholar 

  40. Karch, M. R., Zrenner, B., Deisenhofer, I., et al. (2005). Freedom from atrial tachyarrhythmias after catheter ablation of atrial fibrillation: A randomized comparison between 2 current ablation strategies. Circulation, 111, 2875–2880.

    Article  PubMed  Google Scholar 

  41. Thomas, S. P., Nunn, G. R., Nicholson, I. A., et al. (2000). Mechanism, localization and cure of atrial arrhythmias occurring after a new intraoperative endocardial radiofrequency ablation procedure for atrial fibrillation. Journal of the American College of Cardiology, 35, 442–450.

    Article  PubMed  CAS  Google Scholar 

  42. Mesas, C. E., Pappone, C., Lang, C. C., et al. (2004). Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: Electroanatomic characterization and treatment. Journal of the American College of Cardiology, 44, 1071–1079.

    Article  PubMed  Google Scholar 

  43. Jais, P., Hocini, M., Hsu, L. F., et al. (2004). Technique and results of linear ablation at the mitral isthmus. Circulation, 110, 2996–3002.

    Article  PubMed  Google Scholar 

  44. Takahashi, Y., Jais, P., Hocini, M., et al. (2005). Acute occlusion of the left circumflex coronary artery during mitral isthmus linear ablation. Journal of Cardiovascular Electrophysiology, 16, 1104–1107.

    Article  PubMed  Google Scholar 

  45. Chugh, A., Latchamsetty, R., Oral, H., et al. (2006). Characteristics of cavotricuspid isthmus-dependent atrial flutter after left atrial ablation of atrial fibrillation. Circulation, 113, 609–615.

    Article  PubMed  Google Scholar 

  46. Lee, B. K., Choi, K. J., Kim, J., et al. (2004). Right phrenic nerve injury following electrical disconnection of the right superior pulmonary vein. Pacing and Clinical Electrophysiology, 27, 1444–1446.

    Article  PubMed  Google Scholar 

  47. Pai, R. K., Boyle, N. G., Child, J. S., et al. (2005). Transient left recurrent laryngeal nerve palsy following catheter ablation of atrial fibrillation. Heart Rhythm, 2, 182–184.

    Article  PubMed  Google Scholar 

  48. Shah, D., Dumonceau, J. M., Burri, H., et al. (2005). Acute pyloric spasm and gastric hypomotility: An extracardiac adverse effect of percutaneous radiofrequency ablation for atrial fibrillation. Journal of the American College of Cardiology, 46, 327–330.

    Article  PubMed  Google Scholar 

  49. Scanavacca, M. I., D’Avila, A., Parga, J., et al. (2004). Left atrial-esophageal fistula following radiofrequency catheter ablation of atrial fibrillation. Journal of Cardiovascular Electrophysiology, 15, 960–962.

    Article  PubMed  Google Scholar 

  50. Bunch, T. J., Nelson, J., Foley T., et al. (2006). Temporary esophageal stenting allows healing of esophageal perforations following atrial fibrillation ablation procedures. Journal of Cardiovascular Electrophysiology, 17, 435–439.

    Article  PubMed  Google Scholar 

  51. Doll, N., Borger, M. A., Fabricius, A., et al. (2003). Esophageal perforation during left atrial radiofrequency ablation: Is the risk too high? Journal of Thoracic and Cardiovascular Surgery, 125, 836–842.

    Article  PubMed  Google Scholar 

  52. Lemola, K., Sneider, M., Desjardins, B., et al. (2004). Computed tomographic analysis of the anatomy of the left atrium and the esophagus: Implications for left atrial catheter ablation. Circulation, 110, 3655–3660.

    Article  PubMed  Google Scholar 

  53. Good, E., Oral, H., Lemola, K., et al. (2005). Movement of the esophagus during left atrial catheter ablation for atrial fibrillation. Journal of the American College of Cardiology, 46, 2107–2110.

    Article  PubMed  Google Scholar 

  54. Kottkamp, H., Piorkowski, C., Tanner, H., et al. (2005). Topographic variability of the esophageal left atrial relation influencing ablation lines in patients with atrial fibrillation. Journal of Cardiovascular Electrophysiology, 16, 146–150.

    Article  PubMed  Google Scholar 

  55. Aupperle, H., Doll, N., Walther, T., et al. (2005). Ablation of atrial fibrillation and esophageal injury: Effects of energy source and ablation technique. Journal of Thoracic and Cardiovascular Surgery, 130, 1549–1554.

    Article  PubMed  Google Scholar 

  56. Cummings, J. E., Schweikert, R. A., Saliba, W. I., et al. (2005). Assessment of temperature, proximity, and course of the esophagus during radiofrequency ablation within the left atrium. Circulation, 112, 459–464.

    Article  PubMed  Google Scholar 

  57. Haissaguerre, M., Sanders, P., Hocini, M., et al. (2004). Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome. Circulation, 109, 3007–3013.

    Article  PubMed  Google Scholar 

  58. Ouyang, F., Antz, M., Ernst, S., et al. (2005). Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: Lessons from double Lasso technique. Circulation, 111, 127–135.

    Article  PubMed  Google Scholar 

  59. Ouyang, F., Ernst, S., Chun, J., et al. (2005). Electrophysiological findings during ablation of persistent atrial fibrillation with electroanatomic mapping and double Lasso catheter technique. Circulation, 112, 3038–3048.

    Article  PubMed  Google Scholar 

  60. Nademanee, K., McKenzie, J., Kosar, E., et al. (2004). A new approach for catheter ablation of atrial fibrillation: Mapping of the electrophysiologic substrate. Journal of the American College of Cardiology, 43, 2044–2053.

    Article  PubMed  Google Scholar 

  61. Konings, K. T., Smeets, J. L., Penn, O. C., et al. (1997). Configuration of unipolar atrial electrograms during electrically induced atrial fibrillation in humans. Circulation, 95, 1231–1241.

    PubMed  CAS  Google Scholar 

  62. Oral, H., Chugh, A., Good, E., et al. (2006). A tailored approach to catheter ablation of paroxysmal atrial fibrillation. Circulation, 113, 1824–1831.

    Article  PubMed  Google Scholar 

  63. Marrouche, N. F., Martin, D. O., Wazni, O., et al. (2003). Phased-array intracardiac echocardiography monitoring during pulmonary vein isolation in patients with atrial fibrillation: Impact on outcome and complications. Circulation, 107, 2710–2716.

    Article  PubMed  Google Scholar 

  64. Haissaguerre, M., Hocini, M., Sanders, P., et al. (2006). Localized sources maintaining atrial fibrillation organized by prior ablation. Circulation, 113, 616–625.

    Article  PubMed  Google Scholar 

  65. Haissaguerre, M., Hocini, M., Sanders, P., et al. (2005). Catheter ablation of long-lasting persistent atrial fibrillation: Clinical outcome and mechanisms of subsequent arrhythmias. Journal of Cardiovascular Electrophysiology, 16, 1138–1147.

    Article  PubMed  Google Scholar 

  66. Haissaguerre, M., Sanders, P., Hocini, M., et al. (2005). Catheter ablation of long-lasting persistent atrial fibrillation: Critical structures for termination. Journal of Cardiovascular Electrophysiology, 16, 1125–1137.

    Article  PubMed  Google Scholar 

  67. Oral, H., Chugh, A., Lemola, K., et al. (2004). Noninducibility of atrial fibrillation as an end point of left atrial circumferential ablation for paroxysmal atrial fibrillation: A randomized study. Circulation, 110, 2797–2801.

    Article  PubMed  Google Scholar 

  68. Jais, P., Hocini, M., Sanders, P., et al. (2006). Long-term evaluation of atrial fibrillation ablation guided by noninducibility. Heart Rhythm, 3, 140–145.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aman Chugh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chugh, A., Morady, F. Atrial fibrillation: Catheter ablation. J Interv Card Electrophysiol 16, 15–26 (2006). https://doi.org/10.1007/s10840-006-9018-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10840-006-9018-4

Keywords

Navigation