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StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

This is a case- control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA).

Method

A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation composed the study group. Subjects were genotyped by the polymerase chain reaction restriction fragment length polymorphism method.

Results

The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 5.89 %, 82.35 % and 11.76 %, respectively, for the patient group and 71.76 %, 23.51 % and 4.71 %, respectively, for the control group. Allele frequencies of the G1733A polymorphism among patients and controls were 0.47 and 0.84, respectively, for the dominant allele (G) (wild type) and 0.53 and 0.16, respectively, for the A allele (mutant type).

Conclusions

These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.

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Authors and Affiliations

  1. Medical Genetics Department, Research and Clinical Centre for Infertility, Yazd Shahid Sadoughi Medical Sciences University and Health Services, Yazd, Iran

    Tahere Jahaninejad, Nasrin Ghasemi & Hossein Pashaiefar

  2. Cytogenetic Department, Research and Clinical Centre for Infertility, Yazd Shahid Sadoughi Medical Sciences University and Health Services, Yazd, Iran

    Seyyed Mehdi Kalantar

  3. Molecular Genetics Department, Research and Clinical Centre for Infertility, Yazd Shahid Sadoughi Medical Sciences University and Health Services, Yazd, Iran

    Mohammad Hasan Sheikhha

Authors
  1. Tahere Jahaninejad
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  2. Nasrin Ghasemi
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  3. Seyyed Mehdi Kalantar
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  4. Mohammad Hasan Sheikhha
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  5. Hossein Pashaiefar
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Correspondence to Tahere Jahaninejad.

Additional information

Capsule Our results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.

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Jahaninejad, T., Ghasemi, N., Kalantar, S.M. et al. StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion. J Assist Reprod Genet 30, 437–440 (2013). https://doi.org/10.1007/s10815-013-9949-5

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  • DOI: https://doi.org/10.1007/s10815-013-9949-5

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