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Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

  • Genetics
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Abstract

Purpose

The association between apolipoprotein E (ApoE) gene polymorphism and the risk of recurrent pregnancy loss (RPL) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship.

Method(s)

We searched the PubMed, Embase, and Web of Science data- bases for studies related to the association between the ApoE genotype and the risk of RPL. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association.

Result(s)

Seven studies, including 2,090 RPL cases and 742 control samples, were identified. The results showed a significant association between ApoE E4 mutation and RPL risk (for E4 allele: OR =1.98, 95 %CI =1.14–3.43, P=0.499; for E2E3 vs. E3E3: OR =1.33, 95%CI =1.12–1.42, P=0.008; for E2E4 vs. E3E3: OR =1.26, 95 % CI =1.07–1.49, P=0.005).

Conclusion(s)

The meta-analysis suggests an association between ApoE E4 mutation and increased risk of RPL.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical College, Hohhot, 010050, Inner Mongolia Autonomous Region, China

    Hai-xia Meng, Mu-ge Qi, Yuan-yuan Yi & Ya-ping Liu

Authors
  1. Hai-xia Meng
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  2. Mu-ge Qi
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  3. Yuan-yuan Yi
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  4. Ya-ping Liu
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Corresponding author

Correspondence to Mu-ge Qi.

Additional information

Capsule

The ApoE E4 allele is associated with an increased risk of developing RPL and may be a marker for clinical evaluation.

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Meng, Hx., Qi, Mg., Yi, Yy. et al. Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis. J Assist Reprod Genet 30, 1547–1552 (2013). https://doi.org/10.1007/s10815-013-0118-7

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  • DOI: https://doi.org/10.1007/s10815-013-0118-7

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