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Correlation between embryological factors and pregnancy rate: development of an embryo score in a cryopreservation programme

  • Assisted Reproduction Technologies
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Abstract

Purpose

To establish which embryo parameters, in frozen thawed embryo transfers, have the highest prognosis value in the establishment of pregnancy. The relative importance of different embryo parameters is used to develop an embryo score.

Methods

Retrospective analysis of the implantation rate in 356 frozen/thawed single embryo transfers. A logistic regression model is used to establish an embryo score.

Results

A direct correlation is established between the implantation rate and fresh embryo development (number of blastomeres and their symmetry), survival rate after thawing and mitosis resumption after overnight culture.

Conclusions

An embryo score is developed to determine the implantation potential of frozen/thawed embryos.

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Acknowledgements

The authors wish to thank the members of the Servei de Medicina de la Reproducció of Institut Universitari Dexeus in Barcelona for providing clinical and embryological data essential for the development of this study. This work was done under the auspices of the Catedra d’Investigacio en Obstetricia i Ginecologia.

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Authors and Affiliations

  1. Servei de Medicina de la Reproducció, Departament d’Obstetrícia, Ginecologia i Reproducció, Institut Universitari Dexeus, Sabino de Arana, 5-19, 08028, Barcelona, Spain

    Miquel Solé, Montse Boada, Buenaventura Coroleu, Pere N. Barri & Anna Veiga

  2. Departament de Biologia Cel·lular, Universitat Autònoma de Barcelona, Barcelona, Spain

    Josep Santaló

  3. Unitat de Bioestadística, Departament d’Obstetrícia, Ginecologia i Reproducció, Institut Universitari Dexeus, Barcelona, Spain

    Ignacio Rodríguez

  4. Banc de Línies Cel.lulars, Centre de Medicina Regenerativa de Barcelona, Barcelona, Spain

    Anna Veiga

Authors
  1. Miquel Solé
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  2. Josep Santaló
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  3. Ignacio Rodríguez
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  4. Montse Boada
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  5. Buenaventura Coroleu
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  6. Pere N. Barri
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  7. Anna Veiga
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Corresponding author

Correspondence to Miquel Solé.

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Capsule

In a retrospective study, the relative importance of diferent embryo parameters in a cryopreservation programe is used to develop an embryo score for determining the implantation potential.

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Solé, M., Santaló, J., Rodríguez, I. et al. Correlation between embryological factors and pregnancy rate: development of an embryo score in a cryopreservation programme. J Assist Reprod Genet 28, 129–136 (2011). https://doi.org/10.1007/s10815-010-9498-0

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  • DOI: https://doi.org/10.1007/s10815-010-9498-0

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