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Oocyte cryopreservation: is it time to remove its experimental label?

  • FERTILITY PRESERVATION
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

An Erratum to this article was published on 31 March 2010

Abstract

As more reproductive-age women survive cancer at the expense of gonadotoxic therapy, the need for viable fertility preservation options has become paramount. Embryo cryopreservation, often using donor sperm, has been the standard offered these women over the past 20 years. Preservation of unfertilized oocytes now represents an acceptable and often equally viable alternative, particularly for single women, due to technologic advances made in the past decade. Given such, oocyte cryopreservation’s experimental designation and need for IRB approval should thus be revisited.

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References

  1. Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;19:1884–6.

    Google Scholar 

  2. Chen C. Pregnancies after human oocyte cryopreservation. Ann NY Acad Sci. 1988;541:541–9.

    Article  CAS  PubMed  Google Scholar 

  3. Pickering SJ, Braude RP, Johnston MH, Cant A, Currie J. Transient cooling to room temperature can cause irreversible disruption of the meiotic spindle in the human oocyte. Fertil Steril. 1990;54:102–8.

    CAS  PubMed  Google Scholar 

  4. Schalkoff ME, Oskowitz SP, Powers RD. Ultrastructural observations of human and mouse oocytes treated with cryoprotectants. Biol Reprod. 1989;40:379–93.

    Article  CAS  PubMed  Google Scholar 

  5. Vincent C, Pickering SJ, Johnson MH. The hardening effect of dimethylsulfoxide on the mouse zona pellucida requires the presence of an oocyte and is associated with reduction in the number of cortical granules. J Reprod Fertil. 1990;89:253–9.

    CAS  PubMed  Google Scholar 

  6. Gook DA, Osborn SM, Johnston W. Cryopreservation of mouse and human oocytes using 1,2 propanediol and the configuration of the meiotic spindle. Hum Reprod. 1993;8:1101–9.

    CAS  PubMed  Google Scholar 

  7. Bernard A, Hunter JE, Fuller BJ, Imoedeme D, Curtis P, Jackson A. Fertilization and embryonic development of human oocytes after cooling. Hum Reprod. 1992;7:1447–50.

    CAS  PubMed  Google Scholar 

  8. Gook DA, Osborn SM, Bourne H, Johnston WI. Fertilization of human oocytes following cryopreservation: normal karyotypes and absence of stray chromosomes. Hum Reprod. 1994;9:684–91.

    CAS  PubMed  Google Scholar 

  9. Van Blerkom J, Davis P. Cytogenetic, cellular, and developmental consequences of cryopreservation of immature and mature mouse and human oocytes. Microsc Res Tech. 1994;27:165–93.

    Article  PubMed  Google Scholar 

  10. Cobo A, Rubio C, Gerli S, Ruiz A, Pellicer A, Remohi J. Use of fluorescence in situ hybridization to assess the chromosomal status of embryos obtained from cryopreserved oocytes. Fertil Steril. 2001;75:354–60.

    Article  CAS  PubMed  Google Scholar 

  11. Gook DA, Schiewe M, Osborn SM, Asch RH, Jansen RP, Johnston WI. Intracytoplasmic sperm injection and embryo development of human oocytes cryopreserved using 1, 2-propanediol. Hum Reprod. 1995;10:2637–41.

    CAS  PubMed  Google Scholar 

  12. Porcu E, Fabbri R, Damiano G, Giunchi S, Fartto R, Ciotti P, et al. Clinical experience and applications of oocyte cryopreservation. Mol Cell Endocrinol. 2000;169:33–7.

    Article  CAS  PubMed  Google Scholar 

  13. Coticchio G, Garetti S, Bonu MA, Borini A. Cryopreservation of human oocytes. Hum Fertil. 2001;4:152–7.

    Article  CAS  Google Scholar 

  14. Fabbri R, Porcu E, Marsella T, Rocchetta G, Venturoli S, Flamigni C. Human oocyte cryopreservation: new perspectives regarding oocyte survival. Hum Reprod. 2001;16:411–6.

    Article  CAS  PubMed  Google Scholar 

  15. Bianchi V, Cottichio G, Distratis V, Di Giusto N, Flamigni C, Borini A. Differential sucrose concentration during dehydration (0.2 Mol/L) and rehydration (0.3 Mol/L) increases theimplantation rate of frozen human oocytes. Reprod Biomed Online. 2007;14:64–71.

    Article  CAS  PubMed  Google Scholar 

  16. De Santis L, Cino I, Rabelloti E, Papaleo E, Calzi F, Fusi F, et al. Oocyte cryopreservation: clinical outcome of slow-cooling protocols differing in sucrose concentration. Reprod Biomed Online. 2007;14:57–63.

    Article  PubMed  Google Scholar 

  17. Boldt J, Cline D, McLaughlin D. Human oocyte cryopreservation as an adjunct to IVF-embryo transfer cycles. Hum Reprod. 1993;18:1250–5.

    Article  Google Scholar 

  18. Quintans CJ, Donaldson MJ, Bertolino M, Pasqualini R. Birth of two babies using oocytes that were cryopreserved in a choline based freezing medium. Hum Reprod. 2002;17:3149–52.

    Article  CAS  PubMed  Google Scholar 

  19. Kuleshova L, Gianaroli L, Magli C, Ferraretti A, Trounson A. Birth following vitrification of a small number of human oocytes: case report. Hum Reprod. 2002;14:3077–9.

    Article  Google Scholar 

  20. Kuwayama M, Valta G, Kato O, Leibo S. Highly efficient vitrification method for cryopreservation of human oocytes. Reprod Biomed Online. 2005;11:300–8.

    PubMed  Google Scholar 

  21. Yoon TK, Chung HM, Lim JM, Han SY, Ko JJ, Cha EY. Pregnancy and delivery of healthy infants developed from vitrified oocytes in a stimulated in vitro fertilization-embryo transfer program. Fertil Steril. 2000;734:180–1.

    Article  Google Scholar 

  22. Huang JY, Tulandi T, Holzer H, Tan SL, Chian RC. Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation. Fertil Steril. 2008;89:567–72.

    Article  PubMed  Google Scholar 

  23. Oakes MB, Gomes CM, Fioraventi J, Serafini P, Motta EL, Smith GD. A case of oocyte and embryo vitrification resulting in clinical pregnancy. Fertil Steril. 2008;90(2013):e5–8.

    PubMed  Google Scholar 

  24. Gao S, Li Y, Gao X, Hu J, Yang H, Chen ZJ. Spindle and chromosome changes of human MII oocytes during incubation after slow freezing/fast thawing procedures. Reprod Sci. 2009;16:391–6.

    PubMed  CAS  Google Scholar 

  25. Cobo A, Perez S, De los Santos MJ, Zulatequi J, Domingo J, Remoh J. Effect of different cryopreservation protocols on the metaphase II spindle in human oocytes. Reprod Biomed Online. 2008;17:350–9.

    Article  CAS  PubMed  Google Scholar 

  26. Ciotti PM, Porcu E, Notarangelo L, Magrini O, Buzzocchi A, Venturoli S. Meiotic spindle recovery is faster in vitrification of human oocytes compared to slow freezing. Fertil Steril. 2009;91:2399–407.

    Article  PubMed  Google Scholar 

  27. Coticchio G, DeSantis L, Rossi G, Borini A, Albertini D, Scruravelli G, et al. Sucrose concentration influences the rate of human oocytes with normal spindle and chromosome configurations after slow cooling cryopreservation. Hum Reprod. 2006;21:1771–6.

    Article  CAS  PubMed  Google Scholar 

  28. Rienzi L, Martinez F, Ubaldi F, Minagi MG, Iacobelli M, Tesarik J, et al. Polscope analysis of meiotic spindle changes in living metaphase II human oocytes during the freezing and thawing procedures. Hum Reprod. 2004;19:655–9.

    Article  CAS  PubMed  Google Scholar 

  29. Noyes N, Knopman J, Labella P, McCaffrey C, Clark-Williams M, Grifo J. Oocyte cryopreservation outcomes including pre-cryo and post-thaw meiotic spindle evaluation following slow cooling and vitrification of human oocytes. Fertil Steril. 2010. doi:10.1016/j.fertnstert.2010.01.019.

  30. Borini A, Bonu MA, Coticchio G, Bianchi V, Cattoli M, Flamigni C. Pregnancies and births after oocyte cryopreservation. Fertil Steril. 2004;82:601–5.

    Article  PubMed  Google Scholar 

  31. Levi Setti P, Albani E, Novara P, Cesana A, Morreale G. Cryopreservation of supernumerary oocytes in IVF/ICSI cycles. Hum Reprod. 2006;21:370–5.

    Article  CAS  PubMed  Google Scholar 

  32. Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009;18:769–76.

    Article  CAS  PubMed  Google Scholar 

  33. Grifo JA, Noyes N. Delivery rate using cryopreserved oocytes is comparable to conventional in vitro fertilization using fresh oocytes: potential fertility preservation for female cancer patients. Fertil Steril 2010;93:391–396.

    Google Scholar 

  34. Cobo A, Kuwayama M, Perez S, Ruiz A, Pellicer A, Remohi J. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the CryoTop method. Fertil Steril. 2008;89:1657–64.

    Article  PubMed  Google Scholar 

  35. Nagy ZP, Chang CC, Shapiro DB, Bernal DP, Elsner CW, Mitchell-Leef D, et al. Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. Fertil Steril. 2009;92:520–6.

    Article  PubMed  Google Scholar 

  36. Chian RC, Huang JY, Tan SL, Lucena E, Saa A, Rojas A, et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online. 2008;16:608–10.

    Article  PubMed  Google Scholar 

  37. Porcu E, Venturoli S, Damiano G, Ciotti PM, Notarangelo L, Paradisi R, et al. Healthy twins delivered after oocyte cryopreservation and bilateral ovariectomy for ovarian cancer. Reprod Biomed Online. 2008;17:267–9.

    Article  Google Scholar 

  38. Hoffman DI, Zellman GL, Fair CC, Mayer JF, Zeitz JG, Gibbons WE, et al. Cryopreserved embryos in the United States and their availability for research. Fertil Steril. 2003;79:1063–9.

    Article  PubMed  Google Scholar 

  39. Knopman JM, Talebian S, Berkeley A, Grifo J, Noyes N, Licciardi F. Fate of cryopreserved donor embryos. Fertil Steril, 2009, in press.

  40. Oktay K, Cil A, Bang H. Efficacy of oocyte cryopreservation: a meta-analysis. Fertil Steril. 2006;86:70–80.

    Article  PubMed  Google Scholar 

  41. Patrizio P, Sakkas D. From oocyte to baby: a clinical evaluation of the biological efficiency of in vitro fertilization. Fertil Steril. 2009;91:1061–6.

    Article  PubMed  Google Scholar 

  42. Ezcurra D, Rangnow J, Craig M, Schertz J. The Human Oocyte Preservation Experience (HOPE): a phase IV, prospective, multicenter, observational oocyte cryopreservation registry. Reprod Biol Endocrinol. 2009;7:53.

    Article  PubMed  Google Scholar 

  43. Ezcurra D, Rangnow J, Craig M, Schertz J. The HOPE Registry: first US registry for oocyte cryopreservation. Reprod Biomed Online. 2008;17:743–4.

    Article  PubMed  Google Scholar 

  44. ASRM Practice Committee. ASRM Practice Committee response to Rybak and Lieman: elective self-donation of oocytes. Fertil Steril. 2009;92:1513–4.

    Article  Google Scholar 

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Acknowledgements

The authors would like to acknowledge all those who have worked to improve oocyte cryopreservation success and those who endorse the sentiments of this manuscript including R. Azambuja Ph.D, D. Battaglia Ph.D., B. Behr Ph.D., A. Borini M.D., C. Brigante, G. Centola, P.M. Ciotti, G. Coticchio, A. Cobo Ph.D., I. Cino, F. Calzi, L. De Santis, D. Edgar Ph. D., M.E. Fino M.D., F. Fusi, E. Gismano, D. Gook Ph.D., P. Horvath M.D., K. Ivani, J.M. Knopman M.D., J. Liebermann Ph.D., P. Levi Setti M.D., E. Lucena M.D., M. Mahadevan, D. Morbeck Ph.D., E. Papaleo, P. Patrizio M.D., E. Polak de Fried M.D., E. Porcu M.D., K. Pomeroy, P. Quinn Ph.D., E. Rabellotti, L. Rienzi, S. Silber M.D. and M. Tucker Ph.D.

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Authors and Affiliations

  1. NYU Fertility Center, NYU School of Medicine, 660 First Avenue, Fifth Floor, New York, NY, 10016, USA

    Nicole Noyes

  2. Assisted Fertility Services, Community Health Network, Inc., Indianapolis, IN, 46256, USA

    Jeffrey Boldt

  3. Reproductive Biology Associates, 1150 Lake Hearn Drive, Atlanta, GA, 30342, USA

    Zsolt Peter Nagy

Authors
  1. Nicole Noyes
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  2. Jeffrey Boldt
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  3. Zsolt Peter Nagy
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Correspondence to Nicole Noyes.

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Capsule

As more reproductive-age women survive cancer, the need for fertility preservation is paramount. Oocyte cryopreservation success is increasing; thus, its experimental designation should be revisited.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10815-010-9414-7

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Noyes, N., Boldt, J. & Nagy, Z.P. Oocyte cryopreservation: is it time to remove its experimental label?. J Assist Reprod Genet 27, 69–74 (2010). https://doi.org/10.1007/s10815-009-9382-y

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  • DOI: https://doi.org/10.1007/s10815-009-9382-y

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