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In vitro fertilisation (IVF) with donor eggs in post-menopausal women: are there differences in pregnancy outcomes in women with premature ovarian failure (POF) compared with women with physiological age-related menopause?

  • Assisted Reproduction
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Abstract

Purpose

This study assessed pregnancy rates and obstetric outcomes in women with premature ovarian failure (Group A) with post-menopausal women ≥40 years (Group B) who had IVF ± ICSI using donor eggs.

Methods

This was a retrospective analysis of 54 recipients with either premature ovarian failure or physiological menopause undergoing oocyte donation between 2000 and 2007 at Monash IVF.

Results

The average number of stimulated cycles required for a woman in group A and B to deliver a baby was 1.75 and 1.4 respectively. Both groups had high cumulative pregnancy rates; however, there was a statistically significant difference with regards to rates of complications.

Conclusion

Oocyte donation in both premature ovarian failure and physiological menopause is highly successful and cumulative pregnancy rate is an important statistic which can be used to inform women seeking this technique. High rates of complications, in conjunction with individual risk-factor analysis needs to be considered when counselling post-menopausal women about oocyte donation.

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Author information

Author notes

  1. Devini Ameratunga

    Present address: , 404/5 Greeves St, St Kilda, Melbourne, Victoria, 3182, Australia

Authors and Affiliations

  1. Monash Medical Centre, Clayton, Victoria, Australia

    Devini Ameratunga

  2. Monash IVF, Monash University, Clayton, Victoria, Australia

    Gareth Weston, Tiki Osianlis & James Catt

  3. Centre for Women’s Health Research, Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia

    Beverley Vollenhoven

Authors
  1. Devini Ameratunga
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  2. Gareth Weston
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  3. Tiki Osianlis
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  4. James Catt
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  5. Beverley Vollenhoven
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Corresponding author

Correspondence to Devini Ameratunga.

Additional information

Capsule

Oocyte donation in POF and physiological menopause is highly successful. However, there are significant differences in rates of complications between these two groups.

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Ameratunga, D., Weston, G., Osianlis, T. et al. In vitro fertilisation (IVF) with donor eggs in post-menopausal women: are there differences in pregnancy outcomes in women with premature ovarian failure (POF) compared with women with physiological age-related menopause?. J Assist Reprod Genet 26, 511–514 (2009). https://doi.org/10.1007/s10815-009-9351-5

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  • DOI: https://doi.org/10.1007/s10815-009-9351-5

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