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Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome

  • ASSISTED REPRODUCTION
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Abstract

Purpose

The aim was to determine pregnancy rate following intrauterine insemination (IUI) and its associated factors in a university assisted reproductive technique center in Tehran, Iran.

Methods

A retrospective analysis of 350 IUI cycles with ovarian stimulation by clomiphene citrate and/or gonadotropins was performed.

Results

The overall pregnancy rate was 22% (77/350). Of the 77 pregnancies, 88.3% resulted in live birth, 7.8% in spontaneous abortion, 2.6% in blighted ovum and 1.3% were ectopic. Logistic regression analysis revealed three predictive variables as regards pregnancy: number of the treatment cycle (OR:3.5 CI:1.9 – 6.4 p:0.006), duration of infertility (OR:2.1 CI:1.2 – 3.7 p = 0.001) and age (OR:2.15 CI:1.1 – 4.4 p = 0.04). Pregnancy rate did not have any independent relation to sperm count, type of infertility, number and size of follicle and side of ovulatory ovary.

Conclusion

Our results indicate that clomiphene citrate and/or gonadotropins IUI is a convenient and useful treatment option in women with younger age ( <30 years) and fewer treatment cycles and fewer infertility duration (4 years).

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Acknowledgments

The authors are grateful for assistance from staff in Mahdieh infertility research center. We are especially grateful to our patients for consenting to participate in the study. The authors are indebted to Farzan Institute for Research and Technology for technical assistance.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Shahrzad Zadehmodarres, Belgheis Oladi & Shahrbanoo Saeedi

  2. Tehran University of Medical Sciences, Tehran, Iran

    Haleh Ashraf

  3. Infertility Clinic, Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fatemeh Jahed

Authors
  1. Shahrzad Zadehmodarres
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  2. Belgheis Oladi
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  3. Shahrbanoo Saeedi
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  4. Fatemeh Jahed
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  5. Haleh Ashraf
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Corresponding author

Correspondence to Shahrzad Zadehmodarres.

Additional information

Capsule Best results for intrauterine insemination with ovarian stimulation is obtained in women with younger age, fewer treatment cycles and fewer infertility duration. This study was conducted in Human Reproduction Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Zadehmodarres, S., Oladi, B., Saeedi, S. et al. Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome. J Assist Reprod Genet 26, 7–11 (2009). https://doi.org/10.1007/s10815-008-9273-7

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  • DOI: https://doi.org/10.1007/s10815-008-9273-7

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