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Spectrophotometric Method for the Determination of Two Coformulated Drugs with Highly Different Concentrations. Application on Vildagliptin and Metformin Hydrochloride

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Journal of Applied Spectroscopy Aims and scope

A new smart simple validated spectrophotometric method was developed for the determination of two drugs one of which is in a very low concentration compared to the other. The method is based on spiking and dilution then simple mathematical manipulation of the absorbance spectra. This method was applied for the determination of a binary mixture of vildagliptin and metformin hydrochloride in the ratio 50:850 in laboratory prepared mixtures containing both drugs in this ratio and in pharmaceutical dosage form with good recoveries. The developed method was validated according to ICH guidelines and can be used for routine quality control testing.

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Authors and Affiliations

  1. Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini Str., Cairo, 11562, Egypt

    H. E. Zaazaa, E. S. Elzanfaly, A. T. Soudi & M. Y. Salem

Authors
  1. H. E. Zaazaa
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  2. E. S. Elzanfaly
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  3. A. T. Soudi
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  4. M. Y. Salem
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Corresponding author

Correspondence to A. T. Soudi.

Additional information

Published in Zhurnal Prikladnoi Spektroskopii, Vol. 83, No. 1, pp. 154–157, January–February, 2016.

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Zaazaa, H.E., Elzanfaly, E.S., Soudi, A.T. et al. Spectrophotometric Method for the Determination of Two Coformulated Drugs with Highly Different Concentrations. Application on Vildagliptin and Metformin Hydrochloride. J Appl Spectrosc 83, 137–140 (2016). https://doi.org/10.1007/s10812-016-0256-7

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  • DOI: https://doi.org/10.1007/s10812-016-0256-7

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