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Effects of Cognitive Behavioral Therapy for Reducing Anxiety in Children with High Functioning ASD: A Systematic Review and Meta-Analysis

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Abstract

Children with autism spectrum disorder (ASD) are at greater risk for experiencing high levels of anxiety symptoms. Recent evidence suggests Cognitive behavioral therapy (CBT) may also be effective for anxiety reduction in some presentations of ASD. This meta-analysis evaluated twenty-three studies. Results yielded a moderate effect size (g = − 0.66) for the reduction of anxiety symptoms. Moderators indicated larger effects for studies were achieved with parental involvement (g = − 0.85, p < .05) than with child-only treatments (g = − 0.34, p < .05). Short-term interventions generated a smaller effect (g = − 0.37 p < .05) than either standard-term (g = − 1.02, p < .05) or long-term interventions (g = − 0.69, p < .05).Implications for children with ASD are discussed.

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References

*References marked with an asterisk indicate studies included in the meta-analysis

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th edn.). Washington, DC: Author.

    Book  Google Scholar 

  • Attwood, T. (2004). Exploring feelings: Cognitive behavioural therapy to manage anxiety. Arlington: Future Horizons.

    Google Scholar 

  • Barrett, P. M., Dadds, M. R., & Rapee, R. M. (1996). Family treatment of childhood anxiety: A controlled trial. Journal of Consulting and Clinical Psychology, 64(2), 333–342. https://doi.org/10.1037/0022-006x.64.2.333.

    Article  PubMed  Google Scholar 

  • Bauminger, N. (2002). The facilitation of social-emotional understanding and social interaction in high-functioning children with autism: Intervention outcomes. Journal of autism and developmental disorders, 32(4), 283–298.

    Article  PubMed  Google Scholar 

  • Beaumont, R., & Sofronoff, K. (2008). A multi-component social skills intervention for children with Asperger syndrome: The Junior Detective Training Program. Journal of Child Psychology and Psychiatry, 49(7), 743–753.

    Article  PubMed  Google Scholar 

  • Beck, A. T. (1976). Cognitive therapy and the emotional disorders. New York: International Universities Press.

    Google Scholar 

  • Birmaher, B., Khetarpal, S., Brent, D., Cully, M., Balach, L., Kaufman, J., & Neer, S. M. (1997). The screen for child anxiety related emotional disorders (SCARED): Scale construction and psychometric characteristics. Journal of the American Academy of Child & Adolescent Psychiatry, 36(4), 545–553. https://doi.org/10.1097/00004583-199704000-00018.

    Article  Google Scholar 

  • Boulter, C., Freeston, M., South, M., & Rodgers, J. (2014). Intolerance of uncertainty as a framework for understanding anxiety in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(6), 1391–1402.

    Article  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention. (2018, April 26). Retrieved October 17, 2017, from https://www.cdc.gov/.

  • *Chalfant, A. M., Rapee, R., & Carroll, L. (2006). Treating anxiety disorders in children with high functioning autism spectrum disorders: A controlled trial. Journal of Autism and Developmental Disorders, 37(10), 1842–1857. https://doi.org/10.1007/s10803-006-0318-4.

    Article  PubMed  Google Scholar 

  • Chorpita, B. F. (2007). Modular cognitive-behavioral therapy for childhood anxiety disorders. New York: Guilford Press.

    Google Scholar 

  • Chorpita, B. F., Yim, L. M., Moffitt, C. E., Umemoto, L. A., & Francis, S. E. (2000). Assessment of symptoms of DSM-IV anxiety and depression in children: A Revised Child Anxiety and Depression Scale. Behaviour Research and Therapy, 38, 835–855. https://doi.org/10.1016/S0005-7967(99)00130-8.

    Article  PubMed  Google Scholar 

  • Clark, D. B., Smith, M. G., Neighbors, B. D., Skerlec, L. M., & Randall, J. (1994). Anxiety disorders in adolescence: Characteristics, prevalence, and comorbidities. Clinical Psychology Review, 14(2), 113–137. https://doi.org/10.1016/0272-7358(94)90012-4.

    Article  Google Scholar 

  • *Clarke, C., Hill, V., & Charman, T. (2016). School based cognitive behavioural therapy targeting anxiety in children with autistic spectrum disorder: a quasi-experimental randomised controlled trail incorporating a mixed methods approach. Journal of Autism and Developmental Disorders, 47(12), 3883–3895. https://doi.org/10.1007/s10803-016-2801-x.

    Article  Google Scholar 

  • Cohen, J. (1969). Statistical power analysis for the behavioral sciences. New York: Academic Press.

    Google Scholar 

  • Cook, B., Buysse, V., Klingner, J., Landrum, T., McWilliam, R., Tankersley, M., & Test, D. (2014). Council for Exceptional Children: Standards for evidence-based practices in special education. Teaching Exceptional Children, 46(6), 206.

    Article  Google Scholar 

  • *Drmic, I. E., Aljunied, M., & Reaven, J. (2017). Feasibility, acceptability and preliminary treatment outcomes in a school-based CBT intervention program for adolescents with ASD and anxiety in Singapore. Journal of Autism and Developmental Disorders, 47(12), 3909–3929.

  • *Ehrenreich-May, J., Storch, E. A., Queen, A. H., Rodriguez, J. H., Ghilain, C. S., Alessandri, M.,.. . Wood, J. J. (2014). An open trial of cognitive-behavioral therapy for anxiety disorders in adolescents with autism spectrum disorders. Focus on Autism and Other Developmental Disabilities, 29(3), 145–155. https://doi.org/10.1177/1088357614533381.

    Article  Google Scholar 

  • *Fujii, C., Renno, P., Mcleod, B. D., Lin, C. E., Decker, K., Zielinski, K., & Wood, J. J. (2012). Intensive cognitive behavioral therapy for anxiety disorders in school-aged children with autism: A Preliminary comparison with treatment-as-usual. School Mental Health, 5(1), 25–37. https://doi.org/10.1007/s12310-012-9090-0.

    Article  Google Scholar 

  • Ginsburg, G. S., & Schlossberg, M. C. (2002). Family-based treatment of childhood anxiety disorders. International Review of Psychiatry, 14(2), 143–154. https://doi.org/10.1080/09540260220132662.

    Article  Google Scholar 

  • Guy, W. (1976). ECDEU assessment manual for psychopharmacology. US Dept Health, Education, and Welfare publication; ADM No. 76–338 (pp. 218–222). Rockville: National Institute of Mental Health.

    Google Scholar 

  • Hassall, R., Rose, J., & Mcdonald, J. (2005). Parenting stress in mothers of children with an intellectual disability: the effects of parental cognitions in relation to child characteristics and family support. Journal of Intellectual Disability Research, 49(6), 405–418. https://doi.org/10.1111/j.1365-2788.2005.00673.x.

    Article  PubMed  Google Scholar 

  • Hedges, L. V. (1981). Distribution theory for glass estimator of effect size and related estimators. Journal of Educational and Behavioral Statistics, 6(2), 107–128. https://doi.org/10.3102/10769986006002107.

    Article  Google Scholar 

  • Hedges, L. V., & Vevea, J. L. (1998). Fixed- and random-effects models in meta-analysis. Psychological Methods, 3(4), 486–504. https://doi.org/10.1037/1082-989x.3.4.486.

    Article  Google Scholar 

  • Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine, 21(11), 1539–1558. https://doi.org/10.1002/sim.1186.

    Article  PubMed  Google Scholar 

  • Hofmann, S. G., Asnaani, A., Vonk, I. J., Sawyer, A. T., & Fang, A. (2012). The efficacy of cognitive behavioral therapy: A review of meta-analyses. Cognitive Therapy and Research, 36(5), 427–440.

    Article  PubMed  PubMed Central  Google Scholar 

  • House, A. E., House, B. J., & Campbell, M. B. (1981). Measures of interobserver agreement: Calculation formulas and distribution effects. Journal of Behavioral Assessment, 3(1), 37–57. https://doi.org/10.1007/bf01321350.

    Article  Google Scholar 

  • Keefer, A., Kreiser, N. L., Singh, V., Blakeley-Smith, A., Duncan, A., Johnson, C., … Vasa, R. A. (2017). Intolerance of uncertainty predicts anxiety outcomes following CBT in youth with ASD. Journal of Autism and Developmental Disorders, 47(12), 3949–3958.

    Article  PubMed  Google Scholar 

  • *Keehn, R. H., Lincoln, A. J., Brown, M. Z., & Chavira, D. A. (2012). The coping cat program for children with anxiety and autism spectrum disorder: A pilot randomized controlled trial. Journal of Autism and Developmental Disorders, 43(1), 57–67. https://doi.org/10.1007/s10803-012-1541-9.

    Article  Google Scholar 

  • Kendall, P. C. (1993). Cognitive-behavioral therapies with youth: Guiding theory, current status, and emerging developments. Journal of Consulting and Clinical Psychology, 61(2), 235–247. https://doi.org/10.1037//0022-006x.61.2.235.

    Article  PubMed  Google Scholar 

  • Kendall, P. C., & Hedtke, K. (2006). Cognitive-behavioral therapy for anxious children: Therapist manual (3rd edn.). Ardmore: Workbook Publishing.

    Google Scholar 

  • Kendall, P. C., & Hollon, S. D. (1989). Anxious self-talk: development of the anxious self-statements questionnaire (ASSQ). Cognitive Therapy and Research, 13, 81–93.

    Article  Google Scholar 

  • Kendall, P. C., & Kriss, M. R. (1983). Cognitive-behavioral interventions. In C. E. Walker (Ed.), The handbook of clinical psychology: theory, research and practice (pp. 770–819). Homewood: Dow Jones-Irwin.

    Google Scholar 

  • Kerns, C. M., Kendall, P. C., Berry, L., Souders, M. C., Franklin, M. E., Schultz, R. T., … Herrington, J. (2014). Traditional and atypical presentations of anxiety in youth with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(11), 2851–2861.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim, Y. S., Leventhal, B. L., Koh, Y. J., Fombonne, E., Laska, E., Lim, E. C., … Grinker, R. R. (2011). Prevalence of autism spectrum disorders in a total population sample. American Journal of Psychiatry, 168(9), 904–912. https://doi.org/10.1176/appi.ajp.2011.10101532.

    Article  PubMed  Google Scholar 

  • Lipsey, M. W., & Wilson, D. B. (2001). Practical meta-analysis. Thousand Oaks: Sage.

    Google Scholar 

  • *Luxford, S., Hadwin, J. A., & Kovshoff, H. (2016). Evaluating the effectiveness of a school-based cognitive behavioural therapy intervention for anxiety in adolescents diagnosed with autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(12), 3896–3908. https://doi.org/10.1007/s10803-016-2857-7.

    Article  PubMed Central  Google Scholar 

  • Lyneham, H. J., Abbott, M. J., Wignall, A., & Rapee, R. M. (2003). The Cool Kids Family Program—Therapist Manual. Sydney: Macquarie University.

    Google Scholar 

  • Lyneham, H. J., Street, A. K., Abbott, M. J., & Rapee, R. M. (2008). Psychometric properties of the school anxiety scale—Teacher reported (SAS-TR). Journal of Anxiety Disorders, 22(2), 292–300. https://doi.org/10.1016/j.janxdis.2007.02.001.

    Article  PubMed  Google Scholar 

  • March, J. S. (1997). Multidimensional anxiety scale for children. North Tonawanda: Multi-Health Systems.

    Google Scholar 

  • *Maskey, M., Lowry, J., Rodgers, J., McConachie, H., & Parr, J. R. (2014). Reducing specific phobia/fear in young people with autism spectrum disorders (ASDs) through a virtual reality environment intervention. PloS One, 9(7), e100374.

  • *Mcconachie, H., Mclaughlin, E., Grahame, V., Taylor, H., Honey, E., Tavernor, L.,.. . Couteur, A. L. (2013). Group therapy for anxiety in children with autism spectrum disorder. Autism, 18(6), 723–732. https://doi.org/10.1177/1362361313488839.

    Article  PubMed  Google Scholar 

  • Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine, 151(4), 264–269.

    Article  PubMed  Google Scholar 

  • *Ooi, Y. P., Lam, C. M., Sung, M., Tan, W. T. S., Goh, T. J., Fung, D. S. S., … Chua, A. (2008). Effects of cognitive-behavioural therapy on anxiety for children with high-functioning autistic spectrum disorders. Singapore Medical Journal, 49(3), 215.

  • *Reaven, J., Blakeley-Smith, A., Culhane-Shelburne, K., & Hepburn, S. (2011). Group cognitive behavior therapy for children with high-functioning autism spectrum disorders and anxiety: A randomized trial. Journal of Child Psychology and Psychiatry, 53(4), 410–419. https://doi.org/10.1111/j.1469-7610.2011.02486.x.

    Article  Google Scholar 

  • Reaven, J., Hepburn, S., Nichols, S., Blakely-Smith, A., & Dasari, M. (2005). Coping group: Fighting worry and facing fears: an unpublished treatment manual for children with ASD and anxiety disorder. Denver: University of Colorado at Denver and Health Sciences Center.

    Google Scholar 

  • *Reaven, J. A., Blakeley-Smith, A., Nichols, S., Dasari, M., Flanigan, E., & Hepburn, S. (2008). Cognitive-behavioral group treatment for anxiety symptoms in children with high-functioning autism spectrum disorders. Focus on Autism and Other Developmental Disabilities, 24(1), 27–37. https://doi.org/10.1177/1088357608327666.

    Article  Google Scholar 

  • Research Units on Pediatric Psychopharmacology Autism Network. (2002). Risperidone in children with autism and serious behavioral problems. New England Journal of Medicine, 347, 314–321.

    Article  Google Scholar 

  • Reynolds, C. R., & Richmond, B. O. (1978). What I think and feel: A revised measure of child’s manifest anxiety. Journal of Abnormal Child Psychology, 6(2), 271–280. https://doi.org/10.1007/bf00919131.

    Article  PubMed  Google Scholar 

  • *Scarpa, A., & Reyes, N. M. (2011). Improving emotion regulation with CBT in young children with high functioning autism spectrum disorders: A pilot study. Behavioural and Cognitive Psychotherapy, 39(04), 495–500. https://doi.org/10.1017/s1352465811000063.

    Article  PubMed  Google Scholar 

  • Silverman, W. K., & Albano, A. M. (1996). The anxiety disorders interview schedule for DSM IV-Child and parent versions. SanAntonio: Graywind.

    Google Scholar 

  • Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47(8), 921–929. https://doi.org/10.1097/chi.0b013e318179964f.

    Article  Google Scholar 

  • *Sofronoff, K., Attwood, T., & Hinton, S. (2005). A randomised controlled trial of a CBT intervention for anxiety in children with Asperger syndrome. Journal of Child Psychology and Psychiatry, 46(11), 1152–1160. https://doi.org/10.1111/j.1469-7610.2005.00411.x.

    Article  PubMed  Google Scholar 

  • Spence, S. H. (1998). A measure of anxiety symptoms among children. Behaviour Research and Therapy, 36(5), 545–566. https://doi.org/10.1016/s0005-7967(98)00034-5.

    Article  PubMed  Google Scholar 

  • *Steensel, F. J., & Bögels, S. M. (2015). Cbt for anxiety disorders in children with and without autism spectrum disorders. Journal of Consulting and Clinical Psychology, 83(3), 512–523. https://doi.org/10.1037/a0039108.

    Article  PubMed  Google Scholar 

  • Steensel, F. J., Bögels, S. M., & Perrin, S. (2011). Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clinical Child and Family Psychology Review, 14(3), 302.

    Article  PubMed  PubMed Central  Google Scholar 

  • *Storch, E. A., Arnold, E. B., Lewin, A. B., Nadeau, J. M., Jones, A. M., Nadai, A. S.,.. . Murphy, T. K. (2013). The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: A randomized, controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 52(2). https://doi.org/10.1016/j.jaac.2012.11.007.

    Article  Google Scholar 

  • *Storch, E. A., Lewin, A. B., Collier, A. B., Arnold, E., Nadai, A. S., Dane, B. F.,.. . Murphy, T. K. (2014). A randomized controlled trial of cognitive-behavioral therapy versus treatment as usual for adolescents with autism spectrum disorders and comorbid anxiety. Depression and Anxiety, 32(3), 174–181. https://doi.org/10.1002/da.22332.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sukhodolsky, D. G., Bloch, M. H., Panza, K. E., & Reichow, B. (2013). Cognitive-behavioral therapy for anxiety in children with high-functioning autism: A Meta-analysis. Pediatrics, 132(5). https://doi.org/10.1542/peds.2013-1193.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sukhodolsky, D. G., Scahill, L., Gadow, K. D., Arnold, L. E., Aman, M. G., Mcdougle, C. J.,.. . Vitiello, B. (2007). Parent-rated anxiety symptoms in children with pervasive developmental disorders: Frequency and association with core autism symptoms and cognitive functioning. Journal of Abnormal Child Psychology, 36(1), 117–128. https://doi.org/10.1007/s10802-007-9165-9.

    Article  PubMed  Google Scholar 

  • *Sung, M., Ooi, Y. P., Goh, T. J., Pathy, P., Fung, D. S., Ang, R. P.,.. . Lam, C. M. (2011). Effects of cognitive-behavioral therapy on anxiety in children with autism spectrum disorders: A randomized controlled trial. Child Psychiatry & Human Development, 42(6), 634–649. https://doi.org/10.1007/s10578-011-0238-1.

    Article  Google Scholar 

  • *Thomson, K., Riosa, P. B., & Weiss, J. A. (2015). Brief report of preliminary outcomes of an emotion regulation intervention for children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(11), 3487–3495. https://doi.org/10.1007/s10803-015-2446-1.

    Article  PubMed  Google Scholar 

  • Ung, D., Selles, R., Small, B. J., & Storch, E. A. (2014). A systematic review and meta-analysis of cognitive-behavioral therapy for anxiety in youth with high-functioning autism spectrum disorders. Child Psychiatry & Human Development, 46(4), 533–547. https://doi.org/10.1007/s10578-014-0494-y.

    Article  Google Scholar 

  • Warner, C. M., Warner, C. M., Fisher, P. H., & Klein, R. G. (2007). School-based behavioral intervention for social anxiety disorder in adolescents: Results of an attention control trial and implementation issues. PsycEXTRA Dataset. https://doi.org/10.1037/e533832007-001.

    Article  Google Scholar 

  • *Weiss, J. A., Viecili, M. A., & Bohr, Y. (2014). Parenting stress as a correlate of cognitive behavior therapy responsiveness in children with autism spectrum disorders and anxiety. Focus on Autism and Other Developmental Disabilities, 30(3), 154–164. https://doi.org/10.1177/1088357614547808.

    Article  Google Scholar 

  • White, S. W., Albano, A., Johnson, C., Kasari, C., Ollendick, T., Klin, A., et al. (2010a). Development of a cognitive-behavioral intervention program to treat anxiety and social deficits in teens with high-functioning autism. Clinical Child and Family Psychology Review, 13(1), 77–90. https://doi.org/10.1007/s10567-009-0062-3.

    Article  PubMed  PubMed Central  Google Scholar 

  • *White, S. W., Ollendick, T., Albano, A. M., Oswald, D., Johnson, C., Southam-Gerow, M. A.,.. . Scahill, L. (2012). Randomized controlled trial: multimodal anxiety and social skill intervention for adolescents with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(2), 382–394. https://doi.org/10.1007/s10803-012-1577-x.

    Article  Google Scholar 

  • Wigham, S., Rodgers, J., South, M., McConachie, H., & Freeston, M. (2015). The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(4), 943–952.

    Article  PubMed  Google Scholar 

  • *Wood, J. J., Drahota, A., Sze, K., Har, K., Chiu, A., & Langer, D. A. (2009). Cognitive behavioral therapy for anxiety in children with autism spectrum disorders: a randomized, controlled trial. Journal of Child Psychology and Psychiatry, 50(3), 224–234. https://doi.org/10.1111/j.1469-7610.2008.01948.x.

    Article  PubMed  Google Scholar 

  • *Wood, J. J., Ehrenreich-May, J., Alessandri, M., Fujii, C., Renno, P., Laugeson, E.,.. . Storch, E. A. (2015). Cognitive behavioral therapy for early adolescents with autism spectrum disorders and clinical anxiety: A randomized, controlled trial. Behavior Therapy, 46(1), 7–19. https://doi.org/10.1016/j.beth.2014.01.002.

    Article  PubMed  Google Scholar 

  • Wood, J. J., McLeod, B. D., Hiruma, L. S., & Phan, A. Q. (2008). Child anxiety disorders: A family-based treatment manual for practitioners. New York: WW Norton & Co.

    Google Scholar 

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Perihan, C., Burke, M., Bowman-Perrott, L. et al. Effects of Cognitive Behavioral Therapy for Reducing Anxiety in Children with High Functioning ASD: A Systematic Review and Meta-Analysis. J Autism Dev Disord 50, 1958–1972 (2020). https://doi.org/10.1007/s10803-019-03949-7

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