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Autistic Spectrum Disorders in Velo-cardio Facial Syndrome (22q11.2 Deletion)

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Abstract

The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

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Acknowledgement

This work was supported by NIH grants MH64824 and MH65481 to Wendy Kates.

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Authors and Affiliations

  1. State University of New York - Upstate Medical University, Syracuse, NY, USA

    Kevin M. Antshel, Alka Aneja, Jena Peebles, Wanda P. Fremont, Kimberly Stallone, Nuria AbdulSabur, Anne Marie Higgins, Robert J. Shprintzen & Wendy R. Kates

  2. Kennedy Krieger Institute, Baltimore, MD, USA

    Leslie Strunge

  3. Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Wendy R. Kates

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  1. Kevin M. Antshel
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Correspondence to Kevin M. Antshel.

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Antshel, K.M., Aneja, A., Strunge, L. et al. Autistic Spectrum Disorders in Velo-cardio Facial Syndrome (22q11.2 Deletion). J Autism Dev Disord 37, 1776–1786 (2007). https://doi.org/10.1007/s10803-006-0308-6

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