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Cathodically pretreated poly(1-aminoanthraquinone)-modified electrode for determination of ascorbic acid, dopamine, and uric acid

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Abstract

This paper describes a rapid and reliable method for dopamine (DA), ascorbic acid (AA), and uric acid (UA) determination in human urine using a cathodically pretreated poly(1-aminoanthraquinone) (PAAQ)-modified electrode. By applying a simple cathodic pretreatment to the PAAQ electrode well-defined voltammetric peaks for AA, DA, and UA were obtained. The pretreated PAAQ showed good selectivity, sensitivity, and repeatability for measuring AA, DA, and UA with detection limits of 2.50 × 10−5, 3.05 × 10−6, and 1.15 × 10−5 M, respectively. The practical applicability of the modified electrode is illustrated by selective measurements of AA and UA in human urine without any preliminary treatment. Recovery values between 94.8 and 102 % for AA and between 77.8 and 100 % for UA were obtained with a relative standard deviation of 2.74 and 2.98 %, respectively.

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References

  1. Joseph MH, Young AMJ (1991) Pharmacological evidence, using in vivo dialysis, that substances additional to ascorbic-acid, uric-acid and homovanillic-acid contribute to the voltammetric signals obtained in unrestrained rats from chronically implanted carbon paste electrodes. J Neurosci Methods 36:209–218. doi:10.1016/0165-0270(91)90047-4

    Article  CAS  Google Scholar 

  2. Oneill RD, Gonzalezmora JL, Boutelle MG, Ormonde DE, Lowry JP, Duff A, Fumero B, Fillenz M, Mas M (1991) Anomalously high-concentrations of brain extracellular uric-acid detected with chronically implanted probes—implications for in vivo sampling techniques. J Neurochem 57:22–29. doi:10.1111/j.1471-4159.1991.tb02094.x

    Article  CAS  Google Scholar 

  3. Dursun Z, Gelmez B (2010) Simultaneous determination of ascorbic acid, dopamine and uric acid at Pt nanoparticles decorated multiwall carbon nanotubes modified GCE. Electroanalysis 22:1106–1114. doi:10.1002/elan.200900525

    Article  CAS  Google Scholar 

  4. Njagi J, Chernov MM, Leiter JC, Andreescu S (2010) Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor. Anal Chem 82:989–996. doi:10.1021/ac9022605

    Article  CAS  Google Scholar 

  5. Habibi B, Pournaghi-Azar MH (2010) Simultaneous determination of ascorbic acid, dopamine and uric acid by use of a MWCNT modified carbon-ceramic electrode and differential pulse voltammetry. Electrochim Acta 55:5492–5498. doi:10.1016/j.electacta.2010.04.052

    Article  CAS  Google Scholar 

  6. Kim Y-R, Bong S, Kang Y-J, Yang Y, Mahajan RK, Kim JS, Kim H (2010) Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes. Biosens Bioelectron 25:2366–2369. doi:10.1016/j.bios.2010.02.031

    Article  CAS  Google Scholar 

  7. Liu X, Peng Y, Qu X, Ai S, Han R, Zhu X (2011) Multi-walled carbon nanotube-chitosan/poly(amidoamine)/DNA nanocomposite modified gold electrode for determination of dopamine and uric acid under coexistence of ascorbic acid. J Electroanal Chem 654:72–78. doi:10.1016/j.jelechem.2011.01.024

    Article  CAS  Google Scholar 

  8. Brunetti B, Desimoni E (2011) A new voltammetric sensor based on a glassy carbon electrode modified with 8-hydroxyquinoline-5-sulfonic acid. Electroanalysis 23:1116–1122. doi:10.1002/elan.201000601

    Article  CAS  Google Scholar 

  9. Shi W, Liu C, Song Y, Lin N, Zhou S, Cai X (2012) An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites. Biosens Bioelectron 38:100–106. doi:10.1016/j.bios.2012.05.004

    Article  CAS  Google Scholar 

  10. Marti M, Fabregat G, Estrany F, Aleman C, Armelin E (2010) Nanostructured conducting polymer for dopamine detection. J Mater Chem 20:10652–10660. doi:10.1039/C0JM01364A

    Article  CAS  Google Scholar 

  11. Sen Teker M, Tamer U, Pekmez NO (2012) Fabrication and characterization of poly(vinylferrocenium) perchlorate/poly(3,4-ethylenedioxythiophene) composite-coated electrode in methylene chloride. Synth Met 162:924–930. doi:10.1016/j.synthmet.2012.04.017

    Article  Google Scholar 

  12. Troiani EP, Faria RC (2010) The influence of the cathodic pretreatment on the electrochemical detection of dopamine by poly(1-aminoanthracene) modified electrode. Electroanalysis 22:2284–2289. doi:10.1002/elan.201000225

    Article  CAS  Google Scholar 

  13. Kalimuthu P, John SA (2009) Electropolymerized film of functionalized thiadiazole on glassy carbon electrode for the simultaneous determination of ascorbic acid, dopamine and uric acid. Bioelectrochemistry 77:13–18. doi:10.1016/j.bioelechem.2009.04.010

    Article  CAS  Google Scholar 

  14. Kalimuthu P, John SA (2010) Simultaneous determination of ascorbic acid, dopamine, uric acid and xanthine using a nanostructured polymer film modified electrode. Talanta 80:1686–1691. doi:10.1016/j.talanta.2009.10.007

    Article  CAS  Google Scholar 

  15. Ali SR, Parajuli RR, Balogun Y, Ma YF, He HX (2008) A nonoxidative electrochemical sensor based on a self-doped polyaniline/carbon nanotube composite for sensitive and selective detection of the neurotransmitter dopamine: a review. Sensors 8:8423–8452. doi:10.3390/s8128423

    Article  CAS  Google Scholar 

  16. Atta NF, El-Kady MF (2009) Poly(3-methylthiophene)/palladium sub-micro-modified sensor electrode. Part II: Voltammetric and EIS studies, and analysis of catecholamine neurotransmitters, ascorbic acid and acetaminophen. Talanta 79:639–647. doi:10.1016/j.talanta.2009.04.040

    Article  CAS  Google Scholar 

  17. Atta NF, El-Kady MF (2010) Novel poly(3-methylthiophene)/Pd, Pt nanoparticle sensor: Synthesis, characterization and its application to the simultaneous analysis of dopamine and ascorbic acid in biological fluids. Sens Actuators B 145:299–310. doi:10.1016/j.snb.2009.12.014

    Article  CAS  Google Scholar 

  18. Santos A, Zucolotto V, Constantino C, Cunha H, dos Santos J, Eiras C (2007) Electroactive LbL films of metallic phthalocyanines and poly(o-methoxyaniline) for sensing. J Solid State Electrochem 11:1505–1510. doi:10.1007/s10008-007-0338-9

    Article  CAS  Google Scholar 

  19. Stoyanova A, Tsakova V (2010) Copper-modified poly(3,4-ethylenedioxythiophene) layers for selective determination of dopamine in the presence of ascorbic acid: I. Role of the polymer layer thickness. J Solid State Electrochem 14:1947–1955. doi:10.1007/s10008-010-1007-y

    Article  CAS  Google Scholar 

  20. Tiwari I, Singh KP, Singh M, Banks CE (2012) Polyaniline/polyacrylic acid/multi-walled carbon nanotube modified electrodes for sensing ascorbic acid. Anal Methods 4:118–124. doi:10.1039/c1ay05415e

    Article  CAS  Google Scholar 

  21. Zucolotto V, Ferreira M, Cordeiro MR, Constantino CJL, Moreira WC, Oliveira ON (2006) Nanoscale processing of polyaniline and phthalocyanines for sensing applications. Sens Actuators B 113:809–815. doi:10.1016/j.snb.2005.03.114

    Article  CAS  Google Scholar 

  22. D’Eramo F, Sereno LE, Arevalo AH (2006) Preparation, characterization and analytical applications of a new and novel electrically conducting polymer. Electroanalysis 18:1523–1530. doi:10.1016/j.materresbull.2004.10.014

    Article  Google Scholar 

  23. Ghita M, Arrigan DWM (2004) Electrochemical overoxidation of polyindole and its cation-permselective behavior. Electroanalysis 16:979–987. doi:10.1002/elan.200302938

    Article  CAS  Google Scholar 

  24. Li YX, Wang P, Wang L, Lin XQ (2007) Overoxidized polypyrrole film directed single-walled carbon nanotubes immobilization on glassy carbon electrode and its sensing applications. Biosens Bioelectron 22:3120–3125. doi:10.1016/j.bios.2007.02.001

    Article  CAS  Google Scholar 

  25. Majidi MR, Asadpour-Zeynali K, Gholizadeh S (2009) Amperometric biosensor for dopamine determination based on over-oxidized polypyrrole-plant tissue composite. Int J Polym Anal Charact 14:89–101. doi:10.1016/j.colsurfb.2011.08.012

    Article  CAS  Google Scholar 

  26. Silva QG, Troiani EP, Barbosa NV, Faria RC (2011) Electrochemical determination of norepinephrine on cathodically pretreated poly(1,5-diaminonaphthalene) modified electrode. Electroanalysis 23:1359–1364. doi:10.1002/elan.201100001

    Article  Google Scholar 

  27. Martinez JG, Otero TF (2012) Biomimetic dual sensing-actuators: theoretical description. Sensing electrolyte concentration and driving current. J Phys Chem B 116:9223–9230. doi:10.1021/jp302931k

    Article  CAS  Google Scholar 

  28. Otero TF (2009) Soft, wet, and reactive polymers. Sensing artificial muscles and conformational energy. J Mater Chem 19:681–689. doi:10.1039/b809485c

    Article  CAS  Google Scholar 

  29. Otero TF, Grande H, Rodríguez J (1995) A new model for electrochemical oxidation of polypyrrole under conformational relaxation control. J Electroanal Chem 394:211–216. doi:10.1016/0022-0728(95)04033-K

    Article  Google Scholar 

  30. Otero TF, Grande H-J, Rodríguez J (1997) Reinterpretation of polypyrrole electrochemistry after consideration of conformational relaxation processes. J Phys Chem B 101:3688–3697. doi:10.1021/jp9630277

    Article  CAS  Google Scholar 

  31. Otero TF, Martinez JG, Arias-Pardilla J (2012) Biomimetic electrochemistry from conducting polymers. A review artificial muscles, smart membranes, smart drug delivery and computer/neuron interfaces. Electrochim Acta 84:112–128. doi:10.1016/j.electacta.2012.03.097

    Article  CAS  Google Scholar 

  32. Badawy WA, Ismail KM, Medany SaS (2006) Optimization of the electropolymerization of 1-amino-9,10-anthraquinone conducting films from aqueous media. Electrochim Acta 51:6353–6360. doi:10.1016/j.electacta.2006.04.021

    Article  CAS  Google Scholar 

  33. Otero TF, García de Otazo JM (2009) Polypyrrole oxidation: kinetic coefficients, activation energy and conformational energy. Synth Met 159:681–688. doi:10.1016/j.synthmet.2008.12.017

    Article  CAS  Google Scholar 

  34. Xu XW, Lin QH, Liu AL, Chen W, Weng XH, Wang CL, Lin XH (2010) Simultaneous voltammetric determination of ascorbic acid, Dopamine and uric acid using polybromothymol blue film-modified glassy carbon electrode. Chem Pharm Bull 58:788–793

    Article  CAS  Google Scholar 

  35. Mazloum-Ardakani M, Sheikh-Mohseni MA, Benvidi A (2011) Electropolymerization of thin film conducting polymer and its application for simultaneous determination of ascorbic acid, dopamine and uric acid. Electroanalysis 23:2822–2831. doi:10.1002/elan.201100289

    Article  CAS  Google Scholar 

  36. Niu X, Yang W, Guo H, Ren J, Yang F, Gao J (2012) A novel and simple strategy for simultaneous determination of dopamine, uric acid and ascorbic acid based on the stacked graphene platelet nanofibers/ionic liquids/chitosan modified electrode. Talanta 99:984–988. doi:10.1016/j.talanta.2012.07.077

    Article  CAS  Google Scholar 

  37. Zhu S, Li H, Niu W, Xu G (2009) Simultaneous electrochemical determination of uric acid, dopamine, and ascorbic acid at single-walled carbon nanohorn modified glassy carbon electrode. Biosens Bioelectron 25:940–943. doi:10.1016/j.bios.2009.08.022

    Article  CAS  Google Scholar 

  38. Han D, Han T, Shan C, Ivaska A, Niu L (2010) Simultaneous determination of ascorbic acid, dopamine and uric acid with chitosan–graphene modified electrode. Electroanalysis 22:2001–2008. doi:10.1002/elan.201000094

    Article  CAS  Google Scholar 

  39. Thiagarajan S, Chen SM (2007) Preparation and characterization of PtAu hybrid film modified electrodes and their use in simultaneous determination of dopamine, ascorbic acid and uric acid. Talanta 74:212–222. doi:10.1016/j.talanta.2007.05.049

    Article  CAS  Google Scholar 

  40. Yu SJ, Luo CH, Wang LW, Peng H, Zhu ZQ (2013) Poly(3,4-ethylenedioxythiophene)-modified Ni/silicon microchannel plate electrode for the simultaneous determination of ascorbic acid, dopamine and uric acid. Analyst 138:1149–1155. doi:10.1039/c2an36335f

    Article  CAS  Google Scholar 

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Acknowledgments

The authors acknowledge financial support from the Brazilian research funding agencies FAPESP, CNPq, and CAPES. The authors are also indebted to FAPESP (São Paulo State Research Funding Agency) for funding the Project (Proc. No. 08/06867-8).

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  1. Departamento de Química, Universidade Federal de São Carlos, Rod. Washington Luis km 235, São Carlos, SP, 13565-905, Brazil

    Estela de Pieri Troiani & Ronaldo Censi Faria

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  1. Estela de Pieri Troiani
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  2. Ronaldo Censi Faria
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Correspondence to Ronaldo Censi Faria.

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Troiani, E., Faria, R.C. Cathodically pretreated poly(1-aminoanthraquinone)-modified electrode for determination of ascorbic acid, dopamine, and uric acid. J Appl Electrochem 43, 919–926 (2013). https://doi.org/10.1007/s10800-013-0577-7

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  • DOI: https://doi.org/10.1007/s10800-013-0577-7

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