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Impact of prophylactic intracameral moxifloxacin on post-cataract surgery endophthalmitis: data from a tertiary eye care facility in rural India

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Abstract

Purpose

To study the impact of prophylactic intracameral (IC) moxifloxacin on the incidence, clinical profile and outcomes in eyes developing post-cataract surgery endophthalmitis (PCE).

Methods

This was a single-centre, retrospective, comparative, observational study in which all eyes with PCE between June 2013 and May 2014 without IC moxifloxacin prophylaxis (group A) and June 2015–May 2016 with IC moxifloxacin prophylaxis (group B) were analysed.

Results

A total of 101,815 cataract surgeries were performed in group A and 112,967 in group B. PCE was diagnosed in 179 eyes (0.18%) in group A and 92 eyes (0.08%) in group B (p < 0.001). Greater reduction in risk of PCE was seen in subsidised patients compared to private. The presenting and final visual acuity was significantly better in group B (p < 0.05).

Conclusions

Prophylactic IC moxifloxacin reduced the incidence of PCE with maximum benefit being observed for the subsidised patients and also helped achieve a significantly better visual acuity following the resolution of endophthalmitis.

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Data availability

Data are available upon request.

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Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Sadguru Netra Chikitsalaya, Chitrakoot, Madhya Pradesh, India

    Pratik Shenoy, Rashmi Kashikar, Gaurav Mohan Kohli, Mani Sachdeva, Vipul Naman, Devindra Sood, Priyavrat Bhatia, Pradhnya Sen & Alok Sen

  2. National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore

    Eunice Jin Hui Goh & Rupesh Agrawal

  3. Singapore Eye Research Institute, Singapore, Singapore

    Rupesh Agrawal

  4. Moorfields Eye Hospital, London, UK

    Rupesh Agrawal

Authors
  1. Pratik Shenoy
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  2. Eunice Jin Hui Goh
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  3. Rashmi Kashikar
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  4. Gaurav Mohan Kohli
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  5. Mani Sachdeva
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  6. Vipul Naman
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  7. Devindra Sood
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  8. Priyavrat Bhatia
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  9. Pradhnya Sen
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  10. Rupesh Agrawal
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  11. Alok Sen
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Contributions

AS, PS, RK, DS and PS designed and conducted the study; RK, MS, VN and PB collected and analysed the data; PS, AS, RA, EG and GMK prepared, reviewed and approved the manuscript.

Corresponding author

Correspondence to Alok Sen.

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Conflict of interest

The authors report no conflicts of interest.

Ethical approval

The study was performed according to the Declaration of Helsinki and was approved by the institutional review board of the institute.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Shenoy, P., Goh, E.J.H., Kashikar, R. et al. Impact of prophylactic intracameral moxifloxacin on post-cataract surgery endophthalmitis: data from a tertiary eye care facility in rural India. Int Ophthalmol 41, 2729–2736 (2021). https://doi.org/10.1007/s10792-021-01830-0

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  • DOI: https://doi.org/10.1007/s10792-021-01830-0

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