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Comparison of the efficacy of accelerated corneal cross-linking therapy in different pediatric age groups having progressive keratoconus

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Abstract

Purpose

To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups.

Study design

Retrospective, cross-sectional.

Methods

Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (≤ 14 years and 15–18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups.

Results

The mean age was 14.3 ± 1.8 (10–18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (≤ 14 years of age), and 21 (51%) were in group 2 (15–18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit (p < 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 (Z = − 2.44, p = 0.014).

Conclusion

Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (≤ 14 years).

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Availability of data and materials

The data supporting our findings can be found at Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Ophthalmology Department, Cornea section secretary.

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Funding

No commercial relationship exists for any of this article’s authors in the form of financial support or personal financial interest.

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Authors and Affiliations

  1. Ophthalmology Department, Faculty of Medicine, Van Yuzuncu Yil University, 65080, Tusba, Van, Turkey

    Muhammet Derda Ozer, Muhammed Batur, Selma Mesen, Serek Tekın & Erbil Seven

  2. S.B.U, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey

    Tekin Yasar

Authors
  1. Muhammet Derda Ozer
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  2. Muhammed Batur
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  3. Selma Mesen
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  4. Serek Tekın
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  5. Erbil Seven
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  6. Tekin Yasar
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Contributions

MDO, SM performed the data collection, MDO and MB was involved in planning and supervised the work, MDO, MB, ES, ST, TY processed the experimental data, performed the analysis, drafted the manuscript and designed the tables and graphics. All authors discussed the results and commented on the manuscript.

Corresponding author

Correspondence to Muhammet Derda Ozer.

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Conflict of interest

Authors declare that they have no conflict of interest.

Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Surgical and Pharmaceutical Research Ethics Board (IRB: 2019/10-08). The consent for participation from all participants and parents/legally authorized representatives of minors (age below 16) was acquired for the study.

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Written informed consent for publication was obtained from all of the participants.

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Ozer, M.D., Batur, M., Mesen, S. et al. Comparison of the efficacy of accelerated corneal cross-linking therapy in different pediatric age groups having progressive keratoconus. Int Ophthalmol 40, 2651–2658 (2020). https://doi.org/10.1007/s10792-020-01446-w

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  • DOI: https://doi.org/10.1007/s10792-020-01446-w

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