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Relationship between OSDI questionnaire and ocular surface changes in glaucomatous patients

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Abstract

Purpose

To evaluate the quality of life of glaucoma patients using the Ocular Surface Disease Index (OSDI) questionnaire and their association with dry eye clinical signs.

Methods

The study included patients into three groups. The treated group diagnosed with bilateral open-angle glaucoma and treated with one or more topical medication at least 1 year. The operated group underwent glaucoma surgery without the need for topical medications. The control group entered subjects without ocular diseases or previous surgeries. Dry eye clinical signs were evaluated; noninvasive tear break-up time, Meibomian gland depletion (MGD), and conjunctival hyperemia were measured using the Keratograph 5 M. The total-OSDI (T-OSDI) score was divided into the visual field-OSDI and discomfort-OSDI scores.

Results

Two hundred and nine subjects participated in this cross-sectional study, 147 using glaucoma medications, 21 patients underwent glaucoma surgery and 41 were controls. The T-OSDI and subscores were higher in glaucoma patients compared with controls (p < 0.05); we found no differences between treated and surgically groups. Correlations were observed between the T-OSDI values and Schirmer test (p = 0.016), ocular surface staining (p < 0.001) and the MGD (p = 0.006). The subscores were associated with the ocular surface staining (VF p = 0.013 and D p = 0.003). In treated patients, the number of drops per day correlates with T-OSDI and subscores (p = 0.017 and p = 0.005).

Conclusion

OSDI scores increased in the glaucoma patients compared to controls without significant changes between treated and surgical patients. OSDI scores were associated to dry eye signs and medication in glaucoma patients.

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References

  1. Nirmalan PK, Tielsch JM, Katz J et al (2005) Relationship between vision impairment and eye disease to vision-specific quality of life and function in rural India: the Aravind Comprehensive Eye Survey. Investig Ophthalmol Vis Sci 46:2308–2312

    Article  Google Scholar 

  2. Broman AT, Munoz B, Rodriguez J et al (2002) The impact of visual impairment and eye disease on vision-related quality of life in a Mexican-American population: proyecto VER. Investig Ophthalmol Vis Sci 43:3393–3398

    Google Scholar 

  3. Knudtson MD, Klein BE, Klein R et al (2005) Age-related eye disease, quality of life, and functional activity. Arch Ophthalmol 123:807–814. https://doi.org/10.1001/archopht.123.6.807

    Article  PubMed  Google Scholar 

  4. Takahashi G, Otori Y, Urashima M et al (2016) Evaluation of quality of life in Japanese glaucoma patients and its relationship with visual function. J Glaucoma 25:e150–e156. https://doi.org/10.1097/IJG.0000000000000221

    Article  PubMed  Google Scholar 

  5. Sun Y, Lin C, Waisbourd M et al (2016) The impact of visual field clusters on performance-based measures and vision-related quality of life in patients with glaucoma. Am J Ophthalmol 163:45–52. https://doi.org/10.1016/j.ajo.2015.12.006

    Article  PubMed  Google Scholar 

  6. Gracitelli CP, Abe RY, Tatham AJ et al (2015) Association between progressive retinal nerve fiber layer loss and longitudinal change in quality of life in glaucoma. JAMA Ophthalmol 133:384–390. https://doi.org/10.1001/jamaophthalmol.2014.5319

    Article  PubMed  PubMed Central  Google Scholar 

  7. Abe RY, Diniz-Filho A, Costa VP et al (2016) The impact of location of progressive visual field loss on longitudinal changes in quality of life of patients with glaucoma. Ophthalmology 123:552–557. https://doi.org/10.1016/j.ophtha.2015.10.046

    Article  PubMed  Google Scholar 

  8. Campbell MK, Bush TL, Hale WE (1993) Medical conditions associated with driving cessation in community-dwelling, ambulatory elders. J Gerontol 48:S230–S234

    Article  CAS  Google Scholar 

  9. Ramulu PY, West SK, Munoz B et al (2009) Driving cessation and driving limitation in glaucoma: the Salisbury Eye Evaluation Project. Ophthalmology 116:1846–1853. https://doi.org/10.1016/j.ophtha.2009.03.033

    Article  PubMed  PubMed Central  Google Scholar 

  10. Freeman EE, Munoz B, Rubin G, West SK (2007) Visual field loss increases the risk of falls in older adults: the Salisbury eye evaluation. Investig Ophthalmol Vis Sci 48:4445–4450

    Article  Google Scholar 

  11. Lee BL, Wilson MR (2000) Health-related quality of life in patients with cataract and glaucoma. J Glaucoma 9:87–94

    Article  CAS  Google Scholar 

  12. Janz NK, Wren PA, Guire KE et al (2007) Fear of blindness in the Collaborative Initial Glaucoma Treatment Study: patterns and correlates over time. Ophthalmology 114:2213–2220

    Article  Google Scholar 

  13. Rossi GCM, Tinelli C, Pasinetti GM et al (2009) Dry eye syndrome-related quality of life in glaucoma patients. Eur J Ophthalmol 19:572–579

    Article  Google Scholar 

  14. Jaenen N, Baudouin C, Pouliquen P et al (2007) Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol 17:341–349

    Article  CAS  Google Scholar 

  15. Cvenkel B, Stunf S, Kirbis IS, Flezar MS (2015) Symptoms and signs of ocular surface disease related to topical medication in patients with glaucoma. Clin Ophthalmol 9:625–631. https://doi.org/10.2147/OPTH.S81247

    Article  PubMed  PubMed Central  Google Scholar 

  16. Leung EW, Medeiros FA, Weinreb RN (2008) Prevalence of ocular surface disease in glaucoma patients. J Glaucoma 17:350–355. https://doi.org/10.1097/IJG.0b013e31815c5f4f

    Article  PubMed  Google Scholar 

  17. Bron AJ et al (2007) Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 5:108–152

    Article  Google Scholar 

  18. Schiffman RM, Christianson MD, Jacobsen G et al (2000) Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol 118:615–621

    Article  CAS  Google Scholar 

  19. Mathews PM, Ramulu PY, Friedman DS et al (2013) Evaluation of ocular surface disease in patients with glaucoma. Ophthalmology 120:2241–2248. https://doi.org/10.1016/j.ophtha.2013.03.045

    Article  PubMed  Google Scholar 

  20. Bron AJ, Evans VE, Smith JA (2003) Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea 22:640–650

    Article  Google Scholar 

  21. Mengher LS, Pandher KS, Bron AJ (1986) Topical anaesthetic and tear film stability. Acta Ophthalmol 64:79–82

    Article  CAS  Google Scholar 

  22. Mengher LS, Bron AJ, Tonge SR, Gilbert DJ (1985) Effect of fluorescein instillation on the pre-corneal tear film stability. Curr Eye Res 4:9–12

    Article  CAS  Google Scholar 

  23. Lemij HG, Hoevenaars JG, van der Windt C et al (2015) Patient satisfaction with glaucoma therapy: reality or myth? Clin Ophthalmol 9:785–793. https://doi.org/10.2147/OPTH.S78918

    Article  PubMed  PubMed Central  Google Scholar 

  24. Fechtner RD, Godfrey DG, Budenz D et al (2010) Prevalence of ocular surface complaints in patients with glaucoma using topical intraocular pressure-lowering medications. Cornea 29:618–621. https://doi.org/10.1097/ICO.0b013e3181c325b2

    Article  PubMed  Google Scholar 

  25. Arita R, Itoh K, Maeda S et al (2012) Effects of long-term topical anti-glaucoma medications on meibomian glands. Graefe’s Arch Clin Exp Ophthalmol 250:1181–1185. https://doi.org/10.1007/s00417-012-1943-6

    Article  CAS  Google Scholar 

  26. Arita R, Itoh K, Maeda S et al (2012) Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands. Cornea 31:1229–1234. https://doi.org/10.1097/ICO.0b013e31823f8e7d

    Article  PubMed  Google Scholar 

  27. Terai N, Müller-Holz M, Spoerl E, Pillunat LE (2011) Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects. Clin Ophthalmol. https://doi.org/10.2147/OPTH.S18849

    Article  PubMed  PubMed Central  Google Scholar 

  28. Lee SY, Wong TT, Chua J et al (2013) Effect of chronic anti-glaucoma medications and trabeculectomy on tear osmolarity. Eye 27:1142–1150. https://doi.org/10.1038/eye.2013.144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Budenz DL, Hoffman K, Zacchei A (2001) Glaucoma filtering bleb dysesthesia. Am J Ophthalmol 131:626–630

    Article  CAS  Google Scholar 

  30. Neves Mendes CR, Hida RY, Kasahara N (2012) Ocular surface changes in eyes with glaucoma filtering blebs. Curr Eye Res 37:309–311. https://doi.org/10.3109/02713683.2011.635400

    Article  PubMed  Google Scholar 

  31. Sagara H, Iida T, Saito K et al (2012) Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease. Clin Ophthalmol 6:1273–1279. https://doi.org/10.2147/OPTH.S33427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Sagara H, Sekiryu T, Noji H et al (2015) Treatment with sodium hyaluronate eye drops in a patient who had early-onset bleb leakage after trabeculectomy with mitomycin C. Int Med Case Rep J 8:301–304. https://doi.org/10.2147/IMCRJ.S95334

    Article  PubMed  PubMed Central  Google Scholar 

  33. Wang X, Lu X, Yang J et al (2016) Evaluation of dry eye and meibomian gland dysfunction in teenagers with myopia through noninvasive keratograph. J Ophthalmol 2016:6761206. https://doi.org/10.1155/2016/6761206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. de Paiva CS (2017) Effects of aging in dry eye. Int Ophthalmol Clin 57:47–64. https://doi.org/10.1097/IIO.0000000000000170

    Article  PubMed  PubMed Central  Google Scholar 

  35. Saade CE, Lari HB, Berezina TL et al (2015) Topical glaucoma therapy and ocular surface disease: a prospective, controlled cohort study. Can J Ophthalmol 50:132–136. https://doi.org/10.1016/j.jcjo.2014.11.006

    Article  PubMed  Google Scholar 

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Funding

Supported in part by Instituto de Salud Carlos III, “Red temática de Investigación Cooperativa, RETICS RD12/0034/0013 Enfermedades oculares: “Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares”. Supported in part by Instituto de Salud Carlos III, Subvenciones de la Acción Estratégica en Salud 2013–2016, del Programa Estatal de Investigación Orientad, Project PI14/00811.

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Authors and Affiliations

  1. Department of Ophthalmology, Clínica Universidad de Navarra, Universidad de Navarra, Av. Pío XII, 36, Pamplona, Spain

    Adriano Guarnieri, Elena Carnero, Anne-Marie Bleau, Belén Alfonso-Bartolozzi & Javier Moreno-Montañés

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  1. Adriano Guarnieri
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  2. Elena Carnero
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Correspondence to Javier Moreno-Montañés.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Ethic Committee of Clinical Investigation of Navarra) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Guarnieri, A., Carnero, E., Bleau, AM. et al. Relationship between OSDI questionnaire and ocular surface changes in glaucomatous patients. Int Ophthalmol 40, 741–751 (2020). https://doi.org/10.1007/s10792-019-01236-z

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  • DOI: https://doi.org/10.1007/s10792-019-01236-z

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