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Assessment of vascular leakage and its development with FFA among patients treated with intravitreal anti-VEGF due to aggressive posterior ROP

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A Correction to this article was published on 16 November 2019

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Abstract

Objective

Evaluation of vascular leakage and retinal vascular development with fundus fluorescein angiography for infants diagnosed with aggressive posterior retinopathy of prematurity who underwent intravitreal anti-VEGF treatment.

Method

Medical recordings of 30 patients who received RetCam fluorescein angiography during follow-up and had been treated with anti-VEGF on diagnosis of aggressive posterior ROP in the zone I or zone II between the dates of April 2014–January 2017 were evaluated retrospectively.

Results

Fifty-nine eyes of 30 patients were included in the study. Mean birth weight was 1145 g; gestation week was 28.4. Recurrence occurred in 30.5% of the patients, and 10.1% of them were given a second dose of injection of anti-VEGF. Leakage was detected in 15.3% of the eyes during angiography, and all of these eyes were treated with laser photocoagulation. Evaluation of vascular development revealed that in the temporal, complete retinal vascular development was achieved in only 8% of the eyes. It was detected that complete retinal vascularization was not observed in any of the cases which were given second dose of injection due to recurrence. The patients were distributed into groups according to postmenstrual week taken to angiography as 32 eyes of 16 patients in group 1, 17 eyes of 9 patients in group 2 and 10 eyes of 5 patients in group 3. The vascular leakage rate of group 3 patients was statistically significantly higher (p < 0.05) and vascular development between groups was not statistically significant (p > 0.05).

Discussion

With the initiation of FFA usage in pediatric cases, especially treated with anti-VEGF due to retinopathy of prematurity (ROP), more findings (vascular arrest, leakage, and abnormalities, etc.) are obtained than those achieved via ophthalmoscopic examination. In the light of these findings, early intervention with laser photocoagulation in early stages becomes possible enabling prevention of possible blindness.

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Change history

  • 16 November 2019

    In the original publication, the authors’ affiliations were published incorrectly.

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Authors and Affiliations

  1. Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Diyarbakir, Turkey

    Dilbade Yıldız Ekinci, Asli Deger Vural, Sadik Etka Bayramoglu, Ismail Umut Onur & Gulsum Oya Hergunsel

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  1. Dilbade Yıldız Ekinci
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  2. Asli Deger Vural
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Correspondence to Dilbade Yıldız Ekinci.

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Ekinci, D.Y., Vural, A.D., Bayramoglu, S.E. et al. Assessment of vascular leakage and its development with FFA among patients treated with intravitreal anti-VEGF due to aggressive posterior ROP. Int Ophthalmol 39, 2697–2705 (2019). https://doi.org/10.1007/s10792-019-01088-7

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