Abstract
Purpose
To analyze the change in refractive error and the axial length of chronic Vogt–Koyanagi–Harada (VKH) disease.
Methods
Medical records of 106 eyes of 54 adult VKH patients were analyzed. The refractive error and the axial length were compared between the baseline (defined as the time point at least 2 weeks after acute stage of VKH) and the final visit. The rate of the eyes with significant myopia progression [defined as refraction change toward myopia > 1 diopter (D)] was examined. The correlation of the degree of sunset glow fundus/choroidal thickness with the change in refractive error was also evaluated.
Results
At the final visit, the mean refractive error was more myopic and the axial length was longer than at baseline. Seventeen of the 106 eyes (16.0%) showed significant myopia progression. The mean change in refractive error during a follow-up in these 17 eyes was − 2.7 D (range − 7.5 to − 1.1 D). The axial length data both at baseline and at the final visit were obtained only in 8 eyes. The mean change in axial length during a follow-up in these 8 eyes was 1.3 mm (range 0–3.7 mm). In the cases with myopia progression, sunset glow fundus was more frequent and subfoveal choroid was thinner than those without myopia progression.
Conclusions
Myopia progression as well as increase in axial length occurs in VKH disease. The link between choroidal thinning and axial length elongation in VKH patients gives some insights into axial length increase of pathologic myopia.
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H.T., H.T., and K.O.M. were involved in study design; H.T. and H.T. conduct the study; H.T., H.T., and Y.T. contributed to data collection, management, analysis, and interpretation; H.T., H.T., M.M., and K.O.M. prepared, reviewed, and approved the manuscript. The authors thank Professor Duco Hamasaki for his discussions and critical review of the manuscript.
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The authors declare that they have no conflict of interest. Ethical approval: All procedures performed in studies involving human participants were approved by the Ethics Committee of Tokyo Medical and Dental University and were accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
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An informed consent was obtained from all of the patients to perform the examinations, and all agreed that the information collected could be used for future medical research.
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Takahashi, H., Takase, H., Terada, Y. et al. Acquired myopia in Vogt–Koyanagi–Harada disease. Int Ophthalmol 39, 521–531 (2019). https://doi.org/10.1007/s10792-018-0841-2
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DOI: https://doi.org/10.1007/s10792-018-0841-2