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A cross-sectional comparative study on chronic ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series

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Abstract

Purpose

To compare the chronic ocular manifestations in Stevens–Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort.

Methods

All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Tear osmolarity was also measured.

Results

A total of 18 SJS and 4 TEN cases with an average of 92 and 135 months from disease onset were included. The average age of onset was 46.4 ± 16.6 in SJS and 43.5 ± 19.3 in TEN patients. The LogMAR visual acuity was 0.209 ± 0.591 in SJS and 0.489 ± 0.688 in TEN patients (p = 0.048). The average total Sotozono score was 3.75 ± 7.32 in SJS and 6.88 ± 9.49 in TEN (p = 0.358). Neither the age of onset (p = 0.787), length of follow-up (p = 0.256) nor disease type (SJS vs TEN, p = 0.188) predicted the Sotozono score. There was a statistically significant correlation between Sotozono score and LogMAR VA (r s = 0.437, p = 0.003).

Conclusion

The average total Sotozono score was higher in the TEN group than in the SJS group, but the difference was not statistically significant. Nevertheless, the score correlated with the visual acuity which was statistically worse in the TEN group.

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Authors and Affiliations

  1. Department of Ophthalmology, Grantham Hospital, Hospital Authority, Aberdeen, Hong Kong

    Loraine L. W. Chow & Sharon S. W. Chow

  2. Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong

    Alex L. K. Ng, Bonnie N. K. Choy, Kendrick C. Shih, Ian Y. H. Wong & Jimmy S. M. Lai

  3. Division of Dermatology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong

    Johnny C. Y. Chan

Authors
  1. Loraine L. W. Chow
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  2. Alex L. K. Ng
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Correspondence to Alex L. K. Ng.

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Chow, L.L.W., Ng, A.L.K., Chow, S.S.W. et al. A cross-sectional comparative study on chronic ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series. Int Ophthalmol 38, 1155–1160 (2018). https://doi.org/10.1007/s10792-017-0576-5

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  • DOI: https://doi.org/10.1007/s10792-017-0576-5

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