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Acute stroke after intravitreal bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum

A severe systemic adverse event after an off-label procedure

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Abstract

To report the occurrence of acute stroke after intravitreal bevacizumab administration to treat choroidal neovascularization due to angioid streaks in a patient affected by pseudoxanthoma elasticum. A 54-year-old man with pseudoxanthoma elasticum had vision loss because of choroidal neovascularization due to angioid streaks. He underwent two intravitreal bevacizumab injections. Three days after the second procedure the patient was afflicted by acute stroke. Intravitreal injection of bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum could lead to severe systemic adverse events.

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Authors and Affiliations

  1. Anthea Hospital, GVM Care and Research, Via Camillo Rosalba, 35, 70125, Bari, Italy

    Gianluca Besozzi, Andrea Ferrara, Enrico Epifani, Daniela Intini, Margherita Apruzzese, Antonio Provenzano & Michele Vetrugno

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  1. Gianluca Besozzi
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  2. Andrea Ferrara
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  3. Enrico Epifani
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  4. Daniela Intini
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  5. Margherita Apruzzese
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  6. Antonio Provenzano
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  7. Michele Vetrugno
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Correspondence to Gianluca Besozzi.

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Besozzi, G., Ferrara, A., Epifani, E. et al. Acute stroke after intravitreal bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum. Int Ophthalmol 33, 181–183 (2013). https://doi.org/10.1007/s10792-012-9647-9

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  • DOI: https://doi.org/10.1007/s10792-012-9647-9

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