Skip to main content
Log in

Sympathetic ophthalmia following vitreoretinal surgery

  • Case Report
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

The objective is to discuss the characteristics of three patients who developed sympathetic ophthalmia following vitreoretinal surgery. The first case was a 29-year-old man who underwent placement of an encircling band, pars plana vitrectomy, foreign body removal, endolaser photocoagulation, transscleral cryotherapy, and silicone oil injection due to a retained foreign body 3 months after a corneoscleral rupture repair. He experienced visual loss in the fellow eye 2 months after the vitrectomy. An extensive exudative detachment was detected in the fellow eye. Sympathetic ophthalmia was diagnosed and systemic steroids together with azathioprine were initiated. The injured eye was enucleated as there was no useful vision. The other two cases were operated for rhegmatogenous retinal detachments. One underwent placement of an encircling band, pars plana vitrectomy, silicone oil injection, and endolaser photocoagulation with good anatomic outcome. However, 4 months later, the fellow eye experienced severe visual loss with disc swelling and hyperemia and exudative retinal detachment. Systemic steroid was sufficient to reverse the process and the visual acuity recovered. The other case underwent placement of an encircling band, subretinal fluid drainage, SF6 injection and 360° indirect laser photocoagulation. Two years later, he noted a sudden visual decrease in the fellow eye in which we detected a Harada-like extensive exudative detachment. Systemic steroid without immunosuppressive therapy rendered regression of the detachment and recovery of good visual acuity. Sympathetic ophthalmia may occur following vitreoretinal surgery either for trauma-related problems or rhegmatogenous retinal detachment. Since it may present with relatively mild anterior segment findings and mainly posterior segment involvement; any visual disturbance in the fellow eye of a patient with a history of perforating trauma or vitreoretinal surgery should be thoroughly evaluated for sympathetic ophthalmia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

References

  1. Mackenzie W (1830) A practical treatise on diseases of the eye, 3rd edn. Longmans, London (quoted in: Duke-Elder WS, Perkins ES (1996) Diseases of the uveal tract. In: Duke-Elder WS (ed) System of ophthalmology, Vol. IX. C.V. Mosby, St Louis, pp 285–292)

  2. Bilyk JR (2000) Enucleation, evisceration, and sympathetic ophthalmia. Curr Opin Ophthalmol 11:372–386. doi:10.1097/00055735-200010000-00015

    Article  CAS  PubMed  Google Scholar 

  3. Damico FM, Kiss S, Young LH (2005) Sympathetic ophthalmia. Semin Ophthalmol 20:191–197. doi:10.1080/08820530500232100 (Review)

    Article  PubMed  Google Scholar 

  4. Chan CC, Benezra D, Rodrigues MM, Palestine AG, Hsu SM, Murphree AL, Nussenblatt RB (1985) Immunohistochemistry and electron microscopy of choroidal infiltrates and Dalen-Fuchs nodules in sympathetic ophthalmia. Ophthalmology 92:580–590

    CAS  PubMed  Google Scholar 

  5. Chan CC, Nussenblatt RB, Fujikawa LS et al (1986) Sympathetic ophthalmia; immunopathologic findings. Ophthalmology 93:690–695

    CAS  PubMed  Google Scholar 

  6. Kilmartin DJ, Dick AD, Forrester JV (2000) Prospective surveillance of sympathetic ophthalmia in the UK and Republic of Ireland. Br J Ophthalmol 84:259–263. doi:10.1136/bjo.84.3.259

    Article  CAS  PubMed  Google Scholar 

  7. Makley TA Jr, Azar A (1978) Sympathetic ophthalmia. A long-term follow-up. Arch Ophthalmol 96:257–262

    PubMed  Google Scholar 

  8. Marak GE Jr (1979) Recent advances in sympathetic ophthalmia. Surv Ophthalmol 24:141–156. doi:10.1016/0039-6257(79)90018-3 (Review)

    Article  PubMed  Google Scholar 

  9. Albert DM, Diaz-Rohena R (1989) A historical review of sympathetic ophthalmia and its epidemiology. Surv Ophthalmol 34:1–14. doi:10.1016/0039-6257(89)90125-2 (Review)

    Article  CAS  PubMed  Google Scholar 

  10. Liddy L, Stuart J (1972) Sympathetic ophthalmia in Canada. Can J Ophthalmol 7:157–159

    CAS  PubMed  Google Scholar 

  11. Bechrakis NE, Müller-Stolzenburg NW, Helbig H, Foerster MH (1994) Sympathetic ophthalmia following laser cyclocoagulation. Arch Ophthalmol 112:80–84

    CAS  PubMed  Google Scholar 

  12. Margo CE, Pautler SE (1990) Granulomatous uveitis after treatment of a choroidal melanoma with proton-beam irradiation. Retina 10:140. doi:10.1097/00006982-199004000-00010

    Article  CAS  PubMed  Google Scholar 

  13. Wang WJ (1983) Clinical and histopathological report of sympathetic ophthalmia after retinal detachment surgery. Br J Ophthalmol 67:150–152. doi:10.1136/bjo.67.3.150

    Article  CAS  PubMed  Google Scholar 

  14. Lyons C, Tuft S, Lightman S (1997) Sympathetic ophthalmia from inadvertent ocular perforation during conventional retinal detachment surgery. Br J Ophthalmol 81:612. doi:10.1136/bjo.81.7.e608

    Article  CAS  PubMed  Google Scholar 

  15. Gass JD (1982) Sympathetic ophthalmia following vitrectomy. Am J Ophthalmol 93:552

    CAS  PubMed  Google Scholar 

  16. Kilmartin DJ, Dick AD, Forrester JV (2000) Sympathetic ophthalmia risk following vitrectomy: should we counsel patients? Br J Ophthalmol 84:448–449. doi:10.1136/bjo.84.5.448

    Article  CAS  PubMed  Google Scholar 

  17. Abu El-Asrar AM, Al Kuraya H, Al-Ghamdi A (2006) Sympathetic ophthalmia after successful retinal reattachment surgery with vitrectomy. Eur J Ophthalmol 16:891–894

    CAS  PubMed  Google Scholar 

  18. Pollack AL, McDonald HR, Ai E, Green WR, Halpern LS, Jampol LM, Leahy JM, Johnson RN, Spencer WH, Stern WH, Weinberg DV, Werner JC, Williams GA (2001) Sympathetic ophthalmia associated with pars plana vitrectomy without antecedent penetrating trauma. Retina 21:146–154. doi:10.1097/00006982-200104000-00008

    Article  CAS  PubMed  Google Scholar 

  19. Gupta V, Gupta A, Dogra MR (2007) Posterior sympathetic ophthalmia: a single centre long-term study of 40 patients from North India. Eye 22:1459–1464. doi:10.1038/sj.eye.6702927

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zeynep Ozbek.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ozbek, Z., Arikan, G., Yaman, A. et al. Sympathetic ophthalmia following vitreoretinal surgery. Int Ophthalmol 30, 221–227 (2010). https://doi.org/10.1007/s10792-009-9313-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-009-9313-z

Keywords

Navigation