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Long-term control of cystoid macular oedema in noninfectious uveitis with Mycophenolate Mofetil

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Abstract

Purpose To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU). Methods The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics, best corrected visual acuity (BCVA), fluorescein angiography (FA), and optical coherence tomography (OCT) findings were evaluated. Results There were eight females and 11 males with a mean age of 32.9 ± 8.9 years. After a 1-year follow-up, 18/19 patients (31 eyes, 96.9%, P < 0.05) no longer had signs of CMO, as per their FA and OCT findings; the mean central foveal thickness (CFT) was 167.2 ± 12.8 μm. At the last follow-up, only 3/19 patients, all affected by Behçet panuveitis, had recurrences of CMO. Mean BCVA improved from 0.34 ± 0.14 SD at baseline to 0.65 ± 0.2 SD at last follow-up. Conclusions MMF was safe and effective in controlling CMO and in reducing the uveitis relapse rate in patients not responding to traditional immunosuppressants. Further case–controlled studies are mandatory to validate those preliminary results.

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Abbreviations

AZA:

Azathioprine

BPU:

Behçet panuveitis

BS:

Birdshot

CSA:

Cyclosporine A

IIU:

Idiopathic intermediate uveitis

IRV:

Idiopathic retinal vasculitis

IVT:

Intravitreal triamcinolone

STT:

Sub-Tenon triamcinolone

MCP:

Multifocal choroiditis with panuveitis

MMF:

Mycophenolate mofetil

MTX:

Methotrexate

ASAU:

Ankylosing spondylitis associated uveitis

PIA:

Previous immunosuppressive agents

Sarc:

Sarcoidosis

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Authors and Affiliations

  1. Neuroscience Department, Ophthalmology Section, Polytechnic University of Marche, Via Tronto 10, Torrette, Ancona, Italy

    Piergiorgio Neri, Cesare Mariotti, Lucia Mercanti & Alfonso Giovannini

  2. The Eye Clinic, Azienda Ospedaliero-Universitaria, “Ospedali Riuniti”, Ancona, Italy

    Piergiorgio Neri, Cesare Mariotti, Lucia Mercanti & Alfonso Giovannini

  3. Ocular Immunology Unit, Arcispedale S.M. Nuova, Reggio Emilia, Italy

    Luca Cimino

Authors
  1. Piergiorgio Neri
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  2. Cesare Mariotti
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  3. Luca Cimino
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  4. Lucia Mercanti
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  5. Alfonso Giovannini
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Correspondence to Piergiorgio Neri.

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Neri, P., Mariotti, C., Cimino, L. et al. Long-term control of cystoid macular oedema in noninfectious uveitis with Mycophenolate Mofetil. Int Ophthalmol 29, 127–133 (2009). https://doi.org/10.1007/s10792-008-9200-z

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  • DOI: https://doi.org/10.1007/s10792-008-9200-z

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