Abstract
Background To describe a new method of quantifying the amount of plaque-like hard exudates after intravitreal triamcinolone acetonide injection in diabetic macular edema. Methods This study included 22 eyes of 14 patients (mean age, 63 years) with chronic diabetic macular edema and plaque-like hard exudates. The patients were injected with a single dose of 4 mg intravitreal triamcinolone acetonide. The optic disc size as relative size unit was taken to quantify the hard exudates: Total areas of exudates and the optic nerve head were computed from fundus pictures with a digital analysis program on magnified images. The former was divided by the latter, and the results were expressed as a percentage value. The ratio was used to track improvements in a given eye over 6 months. Results Average ratio of hard exudates to optic nerve head area reduced to 81% of its initial value at 1 month (P = 0.007), to 54% at 3 months (P < 0.001) and to 41% at 6 months (P < 0.001). Conclusions The new method allowed detection of a significant reduction of ratio of hard exudates to optic disc area of diabetic plaque-like hard exudates following 4 mg intravitreal triamcinolone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ciardella AP, Klancnik J, Schiff W, Barile G, Langton K, Chang S (2004) Intravitreal triamcinolone for the treatment of diabetic macular oedema with hard exudates: an optical coherence tomography study. Br J Ophthalmol 88:1131–1136
Khairallah M, Zeghidi H, Ladjimi A, Ben Yahya S, Attia S, Zaouali A, Messaoud R (2005) Primary intravitreal triamcinolone acetonide for diabetic massive macular hard exudates. Retina 25:835–839
Avci R, Kaderli B (2006) Intravitreal triamcinolone injection for chronic diabetic macular oedema with severe hard exudates. Grafe’s Arch Clin Exp Ophthalmol 244:28–35
Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GO (1988) Variability of the real dimensions of normal human optic discs. Graefe’s Arch Clin Exp Ophthalmol 226:332–336
Cornsweet TN (2005) Comparisons of fundus image quality. Fundus Imaging Topics No.7 in a series 1–6 (http://www.vispath.com/assets/pdfs/Comparisons_fundusImagingTopics_7.pdf)
Gili Manzanaro P, Carrasco Font C, Martin Rodriqo JC, Yanquela Rodilla J, Arias Puente A (2004) Digital analysis of the optic disc with fundus camera: a study of variability. Arch Soc Esp Oftalmol 79:125–130
Budde WM, Jonas JB, Schönherr U (1999) Age related macular degeneration and optic disc morphology. Am J Ophthalmol 127:220–221
Çekiç O, Chang S, Tseng JJ, Akar Y, Barile GR, Schiff WM (2005) Intravitreal triamcinolone injection for treatment of macular edema secondary to branch retinal vein occlusion. Retina 25:851–855
Møller F, Bek T (2003) The relation between visual acuity, fixation stability, and the size and location of foveal hard exudates after photocoagulation for diabetic maculopathy. A 1-year follow-up study. Graefe’s Arch Clin Exp Ophthalmol 241:458–462
Author information
Authors and Affiliations
Corresponding author
Additional information
This study was presented in part at the meeting of the American Society of Retina Specialists, Cannes, France, September 2006.
Rights and permissions
About this article
Cite this article
Çekiç, O., Bardak, Y., Tığ, U.Ş. et al. Quantitative evaluation of reduction of plaque-like hard exudates in diabetic macular edema after intravitreal triamcinolone injection. Int Ophthalmol 28, 95–99 (2008). https://doi.org/10.1007/s10792-007-9120-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-007-9120-3