Skip to main content

Advertisement

SpringerLink
Log in

Scedosporium apiospermum traumatic endophthalmitis successfully treated with voriconazole

  • Case Report
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

We describe a case of traumatic endophthalmitis due to Scedosporium apiospermum that was successfully treated with a combination of intravitreal and systemic voriconazole. A high dose of 200 μg was used intravitreally without any apparent complications. A brief overview of voriconazole use for treatment of ocular infections is presented, and a comparison is made with antifungal agents traditionally used in ophathalmology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sabo JA, Abdel-Rahman SM (2000) Voriconazole: a new triazole antifungal. Ann Pharmacother 34:1032–1043

    Article  PubMed  CAS  Google Scholar 

  2. Muijsers RBR, Goa KL, Scott LJ (2002) Voriconazole in the treatment of invasive Aspergillosis. Drugs 62:2655–2664

    Article  PubMed  CAS  Google Scholar 

  3. Gao H, Pennesi ME, Shah K et al (2004) Intravitreal voriconazole. An electrographic and histopathologic study. Arch Ophthalmol 122:1687–1692

    Article  PubMed  CAS  Google Scholar 

  4. Marco F, Pfaller MA, Messar SA, Jones RN (1998) Antifungal activity of a new triazole, voriconazole (UK-109,496), compared with three other antifungal agents tested against clinical isolates of filamentous fungi. Med Mycol 36:433–436

    PubMed  CAS  Google Scholar 

  5. Ghannoum MA, Kuhn DM (2002) Vorcionazole: better chances for patients with invasive mycoses. Eur J Med Res 7:242–256

    Google Scholar 

  6. Espinel-Ingroff A, Boyle K, Sheehan DJ (2001) In vitro antifungal activities of voriconazole and reference against as determined by NCCLS methods: review of the literature. Mycopathologia 150:101–115

    Article  PubMed  CAS  Google Scholar 

  7. Hariprasad SM, Mieler WF, Holz ER et al (2004) Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans. Arch Ophthalmol 122:42–47

    Article  PubMed  CAS  Google Scholar 

  8. Thiel MA, Zinkernagel AS, Burhenne J, Kaufmann C, Haefeli W (2007) Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis. Antimicrob Agents Chemother 51:239–244

    Article  PubMed  CAS  Google Scholar 

  9. Axelrod AJ, Peyman GA, Apple DJ (1973) Toxicity of intravitreal injection of amphotericin B. Am J Ophthalmol 76:578–583

    PubMed  CAS  Google Scholar 

  10. Pfaller MA, Messar SA, Hollis RJ et al (2002) In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp. Antimicrob Agents Chemother 46:1723–1727

    Article  PubMed  CAS  Google Scholar 

  11. Reis A, Sundmacher R, Tintelnot K et al (2000) Successful treatment of ocular invasive mould infection (fusariosis) with the new antifungal agent voriconazole. Br J Ophthalmol 84:932–933

    Article  PubMed  CAS  Google Scholar 

  12. Garbino J, Ondrusova A, Baligvo E, Lew D, Bouchuiguir-Wafa K, Rohner P (2002) Successful treatment of Paecilomyces Iliacinus endophthalmitis with voriconazole. Scand J Infect Dis 24:701–703

    Article  Google Scholar 

  13. Abraham OT, Manavathu EK, Cuthright JL et al (1999) In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole and amphotericin B. Diagn Microbiol Infect Dis 33:7–11

    Article  PubMed  CAS  Google Scholar 

  14. Rubin ZA, Somani J (2004) New options for the treatment of invasive fungal infections. Semin Oncol 31(2):91–99

    Article  PubMed  Google Scholar 

  15. Kim JE, Perkins SL, Harris GJ, Milwaukee W (2003) Voriconazole treatment of fungal scleritis and epibulbar abscess resulting from scleral buckle infection. Arch Ophthalmol 121:735–737

    Article  PubMed  Google Scholar 

  16. Scott IU, Cruz-Villegas V, Flynn HW, Miller D (2004) Delayed onset bleb-associated endophthalmitis caused by Lecythophoria mutabilis. Am J Ophthalmol 137:583–585

    Article  PubMed  Google Scholar 

  17. Nulens E, Eggink C, Rijs AJMM, Wesseling P, Verweij PE (2003) Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole. J Clin Microbiol 41(5):2261–2264

    Article  PubMed  Google Scholar 

  18. Nehemy MB, Vasconcelos-Santos DV, Torqueti-Costa L, Magalhaes E (2006) Chronic endophthalmitis due to Verticillium species after cataract surgery treated (or managed) with pars plana vitrectomy and oral and intravitreal voriconazole. Retina 26:225–227

    Article  PubMed  Google Scholar 

  19. Figueroa M, Fortun J, Clement A, Fernandez de Arevalo B (2004) Endogenous endophthalmitis caused by Scedosporium apiospermum treated with voriconazole. Retina 24:319–320

    Article  PubMed  Google Scholar 

  20. Kramer M, Kramer M, Blau H et al (2006) Intravitreal voriconazole for the treatment of endogenous Aspergillus endophthalmitis. Ophthalmology 113:1184–1186

    Article  PubMed  Google Scholar 

  21. Sen P, Gopal L, Sen PR (2006) Intravitreal voriconazole for drug resistant fungal endophthalmitis. Case Ser Retina 26:935–939

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Waikato Hospital, Hamilton, New Zealand

    Andrea Zarkovic & Stephen Guest

  2. Department of Ophthalmology, Greenlane Clinical Center, Auckland, New Zealand

    Andrea Zarkovic

Authors
  1. Andrea Zarkovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen Guest
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrea Zarkovic.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zarkovic, A., Guest, S. Scedosporium apiospermum traumatic endophthalmitis successfully treated with voriconazole. Int Ophthalmol 27, 391–394 (2007). https://doi.org/10.1007/s10792-007-9095-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-007-9095-0

Keywords

Search

Navigation