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The correlation between optical coherence tomographic features and severity of retinopathy, macular thickness and visual acuity in diabetic macular edema

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Abstract

Purpose

To investigate the correlation between the features of optical coherence tomography (OCT) and the severity of concurrent retinopathy, central macular thickness (CMT), and best-corrected visual acuity in clinically significant diabetic macular edema.

Methods

In a prospective study, OCT was performed in 55 eyes of 55 patients with clinically significant diabetic macular edema, in 58 eyes of 30 patients with diabetes without retinopathy, and in 40 eyes of 21 healthy control subjects. The OCT features were categorized into: type 1, sponge-like retinal swelling; type 2, cystoid macular edema; type 3, serous retinal detachment; and type 4, vitreofoveal traction.

Results

The CMT in eyes with diabetic macular edema was significantly higher than in eyes of healthy controls or in eyes of diabetic patients without retinopathy (P < 0.001). Visual acuity correlated with CMT in diabetic macular edema (r = 0.558, P < 0.001). The prevalence of OCT type 1 was significantly higher in eyes with mild-to-moderate non-proliferative retinopathy (NPDR) than in eyes with severe NPDR to proliferative retinopathy (PDR) (P = 0.0069). The prevalence of OCT types 3 and 4 was significantly higher in eyes with severe NPDR to PDR than in eyes with mild-to-moderate NPDR (P = 0.0056). OCT type 1 showed the least CMT (P < 0.001) and the best visual acuity (P = 0.002).

Conclusions

There was a significant correlation between OCT patterns of clinically significant diabetic macular edema and severity of retinopathy, CMT, and visual acuity.

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References

  1. Klein R, Klein BEK, Moss SE (1984) Visual impairment in diabetes. Ophthalmology 91:1–9

    PubMed  CAS  Google Scholar 

  2. Klein R, Klein BEK, Moss Se, Davis MD, DeMets DL (1984) The Wisconsin Epidemiologic Study of Diabetic Retinopathy IV. Diabetic macular edema. Ophthalmology 91:1464–1474

    PubMed  CAS  Google Scholar 

  3. Klein R, Klein BEK, Moss SE, Cruickshanks KJ (1995) The Wisconsin Epidemiologic Study of Diabetic Retinopathy XV. The long-term incidence of macular edema. Ophthalmology 103:7–16

    Google Scholar 

  4. Bresnick GH (1983) Diabetic maculopathy: a critical review highlighting diffuse macular edema. Ophthalmology 90:1301–1317

    PubMed  CAS  Google Scholar 

  5. Kinyoun J, Barton F, Fisher M, Hubbard L, Aiello L, Ferris F III (1989) The ETDRS Research Group. Detection of diabetic macular edema: ophthalmoscopy versus photography—Early Treatment Diabetic Retinopathy Study report number 5. Ophthalmology 96:746–751

    PubMed  CAS  Google Scholar 

  6. Nussenblatt RB, Kaufman SC, Palestine AG, Davis MD, Ferris FL III (1987) Macular thickening and visual acuity: measurement in patients with cystoid macular edema. Ophthalmology 94:1134–1139

    PubMed  CAS  Google Scholar 

  7. Hee MR, Puliafito CA, Duker JS, Reichel E, Coker JG, Wilkins JR, et al (1998) Topography of diabetic macular edema with optical coherence tomography. Ophthalmology 105:360–370

    Article  PubMed  CAS  Google Scholar 

  8. Sánchez-Tocino H, Alvarez-Vidal A, Maldonado MJ, Moreno-Montañés J, Garcīa-Layana (2002) Retinal thickness study with optical coherence tomography in patients with diabetes. Invest Ophthalmol Vis Sci 43:1588–1594

    PubMed  Google Scholar 

  9. Otani T, Kishi S, Maruyama Y (1999) Patterns of diabetic macular edema with optical coherence tomography. Am J Ophthalmol 127:688–693

    Article  PubMed  CAS  Google Scholar 

  10. Goebel W, Kretzchmar-Gross T (2002) Retinal thickness in diabetic retinopathy: a study using optical coherence tomography (OCT). Retina 22:759–767

    Article  PubMed  Google Scholar 

  11. Ozdek SC, Erdinc MA, Gurelik G, Aydin B, Bahceci U, Hasanreisoglu B (2005) Optical coherence tomographic assessment of diabetic macular edema: comparison with fluorescein angiographic and clinical findings. Ophthalmologica 219:86–92

    Article  PubMed  Google Scholar 

  12. Lattanzio R, Brancato R, Pierro L, Bandello F, Iaccher B, Fiore T, et al (2002) Macular thickness measured by optical coherence tomography (OCT) in diabetic patients. Eur J Ophthalmol 12:482–487

    PubMed  CAS  Google Scholar 

  13. Yamamoto S, Yamamoto T, Hayashi M, Takeuchi S (2001) Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms. Graefes Arch Clin Exp Ophthalmol 239:96–101

    PubMed  CAS  Google Scholar 

  14. Catier A, Tadayoni R, Paques M, Erginay A, Haouchine B, Gaudric A, et al (2005) Characterization of macular edema from various etiologies by optical coherence tomography. Am J Ophthalmol 140:200–206

    PubMed  Google Scholar 

  15. Kang SW, Park CY, Ham D-I (2004) The correlation between fluorescein angiographic and optical coherence tomographic features in clinically significant diabetic macular edema. Am J Ophthalmol 137:313–322

    Article  PubMed  Google Scholar 

  16. Hussain A, Hussain N, Nuthetic R (2005) Comparison of mean macular thickness using optical coherence tomography and visual acuity in diabetic retinopathy. Clin Exp Ophthalmol 33:240–245

    Article  Google Scholar 

  17. Ozdemir H, Karacorlu M, Karacorlu S (2005) Serous macular detachment in diabetic cystoid macular oedema. Acta Ophthalmol Scand 83:63–66

    Article  PubMed  Google Scholar 

  18. Browning DJ, McOwen MD, Bowen RM Jr, O’Marah TL (2004) Comparison of clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomography. Ophthalmology 111:712–715

    Article  PubMed  Google Scholar 

  19. Brown JC, Solomon SD, Bressler SB, Schachat AP, DiBernardo C, Bressler NM (2004) Detection of diabetic foveal edema: contact lens biomicroscopy compared with optical coherence tomography. Arch Ophthalmol 122:330–335

    Article  PubMed  Google Scholar 

  20. Early Treatment Diabetic Retinopathy Study Research Group (1985) Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol 103:1796–1806

    Google Scholar 

  21. Early Treatment Diabetic Retinopathy Study Research Group (1991) Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology 98:741–756

    Google Scholar 

  22. Massin P, Duguid G, Erginay A, Haouchine B, Gaudric A (2003) Optical coherence tomography for evaluating diabetic macular edema before and after vitrectomy. Am J Ophthalmol 135:169–177

    Article  PubMed  Google Scholar 

  23. Fine BS, Brucker AJ (1981) Macular edema and cystoid macular edema. Am J Ophthalmol 92:466–481

    PubMed  CAS  Google Scholar 

  24. Yanoff M, Fine BS, Brucker AJ, Eagle RC Jr (1984) Pathology of human cystoid macular edema. Surv Ophthalmol 28 [Suppl]:505–511

    Article  PubMed  Google Scholar 

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Acknowledgement

The authors thank Ms. Connie B. Unisa-Marfil for secretarial work.

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Authors and Affiliations

  1. Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Hisham Alkuraya & Ahmed M. Abu El-Asrar

  2. Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Dustan Kangave

  3. Department of Ophthalmology, King Abdulaziz University Hospital, Airport Road, P.O. Box 245, Riyadh , 11411, Saudi Arabia

    Ahmed M. Abu El-Asrar

Authors
  1. Hisham Alkuraya
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  2. Dustan Kangave
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  3. Ahmed M. Abu El-Asrar
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Correspondence to Ahmed M. Abu El-Asrar.

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Alkuraya, H., Kangave, D. & Abu El-Asrar, A.M. The correlation between optical coherence tomographic features and severity of retinopathy, macular thickness and visual acuity in diabetic macular edema. Int Ophthalmol 26, 93–99 (2005). https://doi.org/10.1007/s10792-006-9007-8

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  • DOI: https://doi.org/10.1007/s10792-006-9007-8

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