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Plasma Homocysteine Levels in Noninsulin-dependent Diabetes Mellitus with Retinopathy and Neovascular Glaucoma

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Abstract

Aim: This study was designed to evaluate plasma homocysteine levels in noninsulin-dependent diabetes mellitus patients (NIDDM) with preproliferative retinopathy and neovascular glaucoma. The experimental goal was to determine the relationship between plasma homocysteine content and the development of microvascular lesions.

Methods:Plasma homocysteine levels were assessed in three experimental groups consisting of healthy controls (n=30), NIDDM patients with preproliferative retinopathy (n=20) and NIDDM patients with neovascular glaucoma (n=20). Homocysteine levels were determined via a fluorescence polarization immunoassay method by an Abbot IMX instrument.

Results:Plasma homocysteine levels in NIDDM patients with preproliferative retinopathy and neovascular glaucoma (n=40) were found to be significantly higher than those of controls (n=30) (p < 0.01). When statistical analysis was performed separately among the three experimental groups, no significant difference in plasma homocysteine levels were found in patients with preproliferative retinopathy compared to controls. However, homocysteine levels in patients with neovascular glaucoma were found to be significantly higher than the control group (p < 0.001). No significant difference in plasma homocysteine levels could be detected between patients with preproliferative retinopathy and neovascular glaucoma.

Conclusions:Hyperhomocysteinemia is a risk factor for the development of microvascular lesions in patients with NIDDM but cannot be used as a marker to assess the progression of lesions observed in neovascular glaucoma.

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Abbreviations

FPIA:

fluorescence polarization immunoassay

IOP:

intraocular pressure

NIDDM:

noninsulin dependent diabetes mellitus

NPV:

negative predictive value

PPV:

positive predictive value

SAH:

S-adenosyl homocysteine

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Akdeniz University, Turkey

    Iclal Yücel & Filiz Müftüoglu

  2. Department of Biochemistry, Antalya, Turkey

    Gültekin Yücel

  3. Fakültesi, Akdeniz Üniversitesi Tıp, Göz Hastalıkları Anabilim Dalı, 07070, Antalya, Turkey

    Iclal Yücel

Authors
  1. Iclal Yücel
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  2. Gültekin Yücel
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  3. Filiz Müftüoglu
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Correspondence to Iclal Yücel.

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Yücel, I., Yücel, G. & Müftüoglu, F. Plasma Homocysteine Levels in Noninsulin-dependent Diabetes Mellitus with Retinopathy and Neovascular Glaucoma. Int Ophthalmol 25, 201–205 (2004). https://doi.org/10.1007/s10792-004-6740-8

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  • DOI: https://doi.org/10.1007/s10792-004-6740-8

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