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Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome

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Abstract

Cardiovascular diseases (CVDs) are a leading cause of global mortality and have a high incidence rate worldwide. The function of inflammasomes in CVDs has received a lot of attention recently, and the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome may be a new target for the prevention and treatment of CVDs. Flavonoids, which are found in food and plant extracts, inhibited inflammation in CVDs by regulating the NLRP3 inflammasome. CB-Dock was used to investigate whether 34 flavonoids from natural products acted on NLRP3 inflammasome. In brief, the PDB format of NLRP3 was selected as a protein file, and 34 flavonoids in SDF format were selected as the ligand file, and then input to CB-Dock for molecular docking. The docking results showed that epigallocatechin-3-gallate (EGCG), amentoflavone, baicalin, scutellarin, vitexin, silibinin, and puerarin had good binding affinities to NLRP3, which could be used as NLRP3 inhibitors, and aid in the discovery of lead compounds for the design and development of CVDs.

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Data availability

The data used to support the findings of this study are available from the corresponding author upon request.

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Funding

This work was financially supported by National Natural Science Foundation of China (82004180, and 81973844), and Key Project Foundation of Natural Science Research in Universities of Anhui Province in China (2022AH050479).

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  1. Hai-yan Fang, Xiao-ni Zhao, and Meng Zhang contributed equally to this work.

Authors and Affiliations

  1. School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic of China

    Hai-yan Fang, Xiao-ni Zhao, Meng Zhang, Yao-yao Ma, Jin-ling Huang & Peng Zhou

  2. Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, 230012, People’s Republic of China

    Jin-ling Huang & Peng Zhou

  3. Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, People’s Republic of China

    Jin-ling Huang & Peng Zhou

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  1. Hai-yan Fang
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Fang, Hy., Zhao, Xn., Zhang, M. et al. Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome. Inflammopharmacol 31, 1715–1729 (2023). https://doi.org/10.1007/s10787-023-01249-2

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