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New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy

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Abstract

Temporal lobe epilepsy (TLE) is present in 30% of epileptic patients and does not respond to conventional treatments. Bone marrow derived mesenchymal stem cells (BMSCs) induce endogenous neural stem cells, inhibit neurodegeneration, and promote brain self-repair mechanisms. The present study addresses the feasibility of BMSCs transplantation against pilocarpine-induced TLE experimentally. BMSCs were injected either intravenously (IV) or in hippocampus bilaterally (IC). Increased cell count of BMSCs was achieved via IC route. BMSCs treatment ameliorated the pilocarpine-induced neurochemical and histological changes, retained amino acid neurotransmitters to the normal level, downregulated the immunoreactivity to insulin growth factor-1 receptor, synaptophysin, and caspase-3 and reduced oxidative insult and inflammatory markers detected in epileptic model. It is worth noting that BMSCs IC-administered showed more pronounced effects than those administered via IV route. BMSCs transplantation presents a promise for TLE treatment that has to be elucidated clinically.

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Authors and Affiliations

  1. Biochemistry Department, Faculty of Science, Al Faisalia, King Abdulaziz University, Jeddah, Saudi Arabia

    Neveen A. Salem

  2. Medical Research Division, Narcotics, Ergogenic Aids and Poisons Department, National Research Centre, El-Bohouth Street, Dokki, Giza, 12622, Egypt

    Neveen A. Salem, Marwa El-Shamarka & Shaimaa El-Shebiney

  3. Medical Research Division, Physiology Department, NRC, Cairo, Egypt

    Yasser Khadrawy

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  1. Neveen A. Salem
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  2. Marwa El-Shamarka
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  3. Yasser Khadrawy
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  4. Shaimaa El-Shebiney
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Correspondence to Neveen A. Salem.

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Salem, N.A., El-Shamarka, M., Khadrawy, Y. et al. New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy. Inflammopharmacol 26, 963–972 (2018). https://doi.org/10.1007/s10787-018-0456-2

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  • DOI: https://doi.org/10.1007/s10787-018-0456-2

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