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Orientin Inhibits High Glucose-Induced Vascular Inflammation In Vitro and In Vivo

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Abstract

Vascular inflammation plays a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Orientin, a C-glycosyl flavonoid, is known to have anxiolytic and antioxidative activity. In this study, we assessed whether orientin can suppress vascular inflammation induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Our data indicate that HG markedly increased vascular permeability, monocyte adhesion, the expression of cell adhesion molecules (CAMs), the formation of reactive oxygen species (ROS), and the activation of nuclear factor kappa B (NF-κB). Remarkably, the vascular inflammatory effects of HG were attenuated by pretreatment with orientin. Since vascular inflammation induced by HG is critical in the development of diabetic complications, our results suggest that orientin may have significant benefits in the treatment of diabetic complications and atherosclerosis.

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ACKNOWLEDGMENTS

This study was supported by the National Research Foundation of Korea (NRF) funded by the Korea government (MSIP) (Grant No. 2013-067053).

Conflict of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, 712-715, Republic of Korea

    Sae-Kwang Ku

  2. College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu, 702-701, Republic of Korea

    Soyoung Kwak & Jong-Sup Bae

Authors
  1. Sae-Kwang Ku
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  2. Soyoung Kwak
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  3. Jong-Sup Bae
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Correspondence to Jong-Sup Bae.

Additional information

Sae-Kwang Ku and Soyoung Kwak contributed equally to this work.

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Ku, SK., Kwak, S. & Bae, JS. Orientin Inhibits High Glucose-Induced Vascular Inflammation In Vitro and In Vivo . Inflammation 37, 2164–2173 (2014). https://doi.org/10.1007/s10753-014-9950-x

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