Abstract
Acute lung injury (ALI) is characterized by alveolar injury and uncontrolled inflammation. Mechanisms underlying pathogenesis of ALI are unknown. Regulatory T cells (Tregs), either natural or induced, suppress a variety of physiological and pathological immune responses. In the current study, we investigated whether Tregs were involved in the development of ALI. Proportion of CD4 + CD25 + FoxP3+ Tregs in the peripheral blood of 66 ALI patients and 30 healthy controls were examined by flow cytometry. Data showed that the percentage of Tregs in CD4+ T cells was significantly increased in patients than that in controls (10.8 versus 7.6 %, P = 0.003). Also, compared to those who died during the study, patients who survived presented significantly higher level of Tregs at the time of recruitment (P = 0.041). Since Tim-3 is a negative regulatory molecule and can modulate the function of Tregs, we evaluated Tim-3 level on Tregs and identified upregulation of the molecule in patients than that in controls. Moreover, compared to those who died during the study, patients who survived showed 1.7-fold higher level of Tim-3 on Tregs at the time of recruitment (P < 0.001). These results suggest that Tregs could affect the prognosis of ALI probably due to the upregulation of Tim-3.
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Song, H., Zhou, Y., Li, G. et al. Regulatory T Cells Contribute to the Recovery of Acute Lung Injury by Upregulating Tim-3. Inflammation 38, 1267–1272 (2015). https://doi.org/10.1007/s10753-014-0096-7
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DOI: https://doi.org/10.1007/s10753-014-0096-7