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Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever

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Abstract

Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs. A retrospective review of medical records of anti-IL-1 recipients was performed. The main clinical characteristics of these patients and the evolution after anti-IL-1 were recorded. There were 20 patients (11 male [M] and 9 female [F]). Despite regular colchicine treatment, median number of attacks per month and per year was 1 (1–4) and 12 (4–50), respectively. Twelve patients were receiving anakinra, and eight patients were treated with canakinumab. The number of monthly and yearly attacks after IL-1 treatment was significantly decreased after the biologic agent (p < 0.05). One patient did not respond to the treatment, and one patient developed serious infection during anti-IL-1. We also observed a significant decrease in proteinuria in the amyloidosis complicated FMF patients. Anti-IL-1 targeting drugs seem safe and effective therapies in colchicine-resistant FMF.

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There are no conflicts of interest for any of the authors.

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Authors and Affiliations

  1. Department of Rheumatology, Dokuz Eylul University School of Medicine, 35340, Izmir, Turkey

    Pinar Cetin, Ismail Sari, Merih Birlik, Nurullah Akkoc & Fatos Onen

  2. Department of Pediatrics, Ege University School of Medicine, Izmir, Turkey

    Betul Sozeri & Ozlem Cam

  3. Department of Rheumatology, Katip Celebi University School of Medicine, Izmir, Turkey

    Servet Akar

Authors
  1. Pinar Cetin
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  2. Ismail Sari
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  3. Betul Sozeri
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  4. Ozlem Cam
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  5. Merih Birlik
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  6. Nurullah Akkoc
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  7. Fatos Onen
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  8. Servet Akar
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Correspondence to Ismail Sari.

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Cetin, P., Sari, I., Sozeri, B. et al. Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever. Inflammation 38, 27–31 (2015). https://doi.org/10.1007/s10753-014-0004-1

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  • DOI: https://doi.org/10.1007/s10753-014-0004-1

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