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Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study

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Abstract

We evaluated the levels of some inflammatory adipocytokines in 363 obese and 365 non-obese subjects. We measured: body mass index (BMI), waist circumference (WC), fasting plasma glucose, fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, blood pressure, lipid profile, retinol binding protein-4 (RBP-4), vaspin, omentin-1, leptin, interleukin-6 (IL-6), visfatin, resistin, adiponectin (ADN), adipsin, tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (Hs-CRP). We observed higher BMI, WC, FPI, HOMA index, TC, LDL-C, RBP-4, leptin, IL-6, adipsin, Hs-CRP, vaspin, resistin and TNF-α levels, and lower visfatin, and ADN levels in obese compared to non-obese subjects. Higher WC correlated with lower ADN and visfatin levels, and higher vaspin levels. Higher HOMA index correlated with higher resistin, adipsin, RBP-4, and leptin concentrations, while higher leptin levels correlated with higher TNF-α, Hs-CRP, and IL-6 concentration, and lower ADN values. We confirmed obese subjects’ predisposition to develop dysmetabolic disease and hormonal dysfunctions.

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The authors certify that they have no affiliation with, or financial involvement in, any organization or entity with a direct financial interest in the subject matter or materials discussed in the article.

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  1. Department of Internal Medicine and Therapeutics, University of Pavia, P.le C. Golgi, 2-27100, Pavia, Italy

    Giuseppe Derosa, Elena Fogari, Angela D’Angelo, Lucio Bianchi, Aldo Bonaventura, Davide Romano & Pamela Maffioli

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  1. Giuseppe Derosa
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Derosa, G., Fogari, E., D’Angelo, A. et al. Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study. Inflammation 36, 914–920 (2013). https://doi.org/10.1007/s10753-013-9620-4

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