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Antihypertensive Drugs and Inflammation in Acute Ischemic Stroke as a Predictor Factor of Future Cardiovascular Mortality

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Abstract

The beneficial effects of antihypertensive drugs in secondary stroke prevention could not be based on their effects on lowering hypertension only.In this prospective study, the status of blood pressure, treatment regimens, new atherothrombotic event, blood sampling for hs-CRP and fibrinogen were asked at initial visit, 6th, and 12th months in 226 patients with atherothrombotic stroke.Eighty-seven percent of patients had an antihypertensive regimen, but hypertension control was achieved in 34.1% of patients.Neither use of six different antihypertensive drug regimens nor the change in blood pressure levels showed any difference on new atherothrombotic events, outcomes or survival rates.On the other hand, the higher levels of hs-CRP at baseline were found to be associated with higher mortality rates(p = 0.020).Our findings emphasize the predictive role of inflammation in future cardiovascular mortality in patients with acute ischemic stroke, indicating that inflammatory mediators underlying the atherothrombotic process play a more important role than it is assumed.

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ACKNOWLEDGMENTS

This study was supported by the sponsors, Sanofi-Synthelabo and Bristol Myers-Squibb. The manuscript, however, was written independently from the sponsors. All authors disclose that the have NO financial interests relevant to the research, and have NO conflict of interest.

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Authors and Affiliations

  1. Cerrahpaşa Faculty of Medicine, Department of Neurology, Istanbul University, 34098, Istanbul, Turkey

    Gulcin Benbir & Birsen Ince

  2. Faculty of Medicine, Department of Neurology, Ege University, Izmir, Turkey

    Emre Kumral

  3. Cerrahpaşa Faculty of Medicine, Department of Cardiology, Istanbul University, Istanbul, Turkey

    Zeki Ongen

  4. Faculty of Medicine, Department of Cardiology, Ege University, Izmir, Turkey

    Hakan Kultursay

  5. Faculty of Medicine, Department of Cardiology, Hacettepe University, Ankara, Turkey

    Lale Tokgozoglu & Ali Oto

  6. Cerrahpaşa Faculty of Medicine, Department of Cardiovascular Surgery, Istanbul University, Istanbul, Turkey

    Hasan Tuzun

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Appendix

Appendix

ARDA Investigtors: Neurology: Ufuk Utku (Edirne), Hulki Forta (Istanbul), Baki Arpacı (Istanbul), Ali Ozeren (Adana), Zekeriya Alioglu (Trabzon), Ali Soyuer (Kayseri), Deniz Selcuki (Manisa), H.Rifat Koyuncuoglu (Isparta), Kemal Ozalp (Istanbul), Demet Ozbabalık (Eskisehir), Mustafa Bakar (Bursa), Aynur Ozge (Mersin), Seref Demirkaya (Ankara); Cardiology: Omer Kozan (Izmir), Oktay Sancaktar (Antalya), Ahmet Altınbas (Isparta), Ender Semizer (Denizli), Kenan Sonmez (Istanbul), Akin Serdar (Bursa), Haldun Muderrisoglu (Ankara), Sule Korkmaz (Ankara), Atilla Iyisoy (Ankara), Mahmut Sahin (Samsun), Ramazan Ozdemir (Malatya), Hurkan Kusaklioglu (Ankara), Ramazan Ozdemir (Malatya), Mustafa Gokce (Trabzon), Vedat Aytekin (Istanbul), Huseyin Senocak (Erzurum), Bulent Boyaci (Ankara), Yuksel Altuntas (Istanbul); Cardiovascular Surgery: Cuneyt Koksoy (Ankara), Ali Gurbuz (Izmir), Bayer Cinar (Istanbul), Hafize Yanliz (Adana), Fersat Kolbakir (Samsun), Murat Kayabali (Istanbul), Mustafa Ozbaran (Izmir).

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Benbir, G., Ince, B., Kumral, E. et al. Antihypertensive Drugs and Inflammation in Acute Ischemic Stroke as a Predictor Factor of Future Cardiovascular Mortality. Inflammation 35, 65–73 (2012). https://doi.org/10.1007/s10753-010-9290-4

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