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Investigation of Inflammatory and Hemostatic Parameters in Female Patients Undergoing Total Knee Arthroplasty Surgery

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Abstract

Tendency to hypercoagulation is a common phenomenon in primary osteoarthritis patients (POA) undergoing total knee arthroplasty (TKA) surgery, but the clinical implications of this condition are not clear. Therefore we aimed to evaluate the inflammatory and coagulation parameters in the patient group and find a possible explanation for the tendency to hypercoagulation occurring in plasma and synovia of inflamed joints. Of the evaluated factors involved in inflammation and coagulation, galectin-3, C reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, FVIIa:C, FXII:C, and platelet count increased, whereas tissue factor (TF) activity in synovia, PT, APTT and FVII:C in plasma and synovia were decreased. In conclusion, activation of inflammation and tendency to hypercoagulation is observed in preoperative plasma and synovia of patients undergoing TKA surgery.

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Acknowledgements

We appreciate the support of Dr. Ebru Emekli-Alturfan, PhD, Marmara University, Faculty of Dentistry, Department of Biochemistry.

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Authors and Affiliations

  1. Vocational School Health Services, Cerrahpasa Medical Faculty, Istanbul University, Kocamustafapasa, Istanbul, Turkey

    A. Ata Alturfan

  2. Department of Orthopaedics and Traumatology, Istanbul University Medical Faculty, Capa, Istanbul, Turkey

    Levent Eralp

  3. Department of Biochemistry, School of Dentistry, Marmara University, Nisantasi, Istanbul, Turkey

    Nesrin Emekli

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  1. A. Ata Alturfan
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Alturfan, A.A., Eralp, L. & Emekli, N. Investigation of Inflammatory and Hemostatic Parameters in Female Patients Undergoing Total Knee Arthroplasty Surgery. Inflammation 31, 414–421 (2008). https://doi.org/10.1007/s10753-008-9093-z

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