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C-Reactive Protein is Linked to Lower Cognitive Performance in Overweight and Obese Women

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Abstract

Our objective was to ascertain the nature of the associations between C-reactive protein (CRP) and cognition, and to examine how they are affected by gender and obesity. We evaluated 62 females and 63 males between 42 and 82 years of age. There were 20 lean females with a body mass index (BMI) of <25 kg/m2 and 42 overweight or obese females, with BMIs ≥25 kg/m2. There were 14 lean males and 49 with BMIs ≥25 kg/m2. CRP was associated with lower scores on cognitive tests of frontal lobe function among females and these associations were driven by the overweight/obese female group. In these data no associations between CRP and cognition were found among males. Obesity-associated inflammation is much more prominent in females and it appears to be associated with cognitive dysfunction, particularly of frontal lobe tasks.

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Acknowledgements

The study was supported by grants from the National Institutes of Health DK064087 and P30-AG-08051 and support from the NYU General Clinical Research Center (NCRR M01 RR00096).

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  1. Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, New York, 10016, USA

    V. Sweat, V. Starr, H. Bruehl, A. Arentoft, A. Tirsi, E. Javier & A. Convit

  2. Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd., Orangeburg, New York, New York, 10962, USA

    A. Convit

  3. Millhauser Laboratories, HN-400, New York University School of Medicine, 550 First Avenue, New York, New York, 10016, USA

    A. Convit

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  1. V. Sweat
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Sweat, V., Starr, V., Bruehl, H. et al. C-Reactive Protein is Linked to Lower Cognitive Performance in Overweight and Obese Women. Inflammation 31, 198–207 (2008). https://doi.org/10.1007/s10753-008-9065-3

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