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The metabolic syndrome in heart failure: insights to specific mechanisms

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Abstract

The presence of comorbidities significantly influences long-term morbidity and mortality of symptomatic and asymptomatic heart failure (HF) patients. Metabolic syndrome and diabetic cardiomyopathy are two clinical conditions that share multiple pathophysiological mechanisms and that might be both responsible for cardiac dysfunction. However, it is argued whether metabolic syndrome (MS) independently increases HF risk or the association between MS and HF merely reflects the impact of individual risk factors included in its definition on HF development. Similarly, in the context of diabetic cardiomyopathy, many aspects are still challenging starting from the definition up to the therapeutic management. In this clinical review, we focused the attention on molecular pathways, myocyte alterations, and specific patterns of metabolic syndrome and diabetic cardiomyopathy in order to better define the potential diagnostic and therapeutic approaches of these two pathological conditions.

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Authors and Affiliations

  1. IRCCS SDN, Naples, Italy

    Paola Gargiulo

  2. Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy

    Fabio Marsico, Francesco Renga, Simona Dell’Aversana, Immacolata Esposito, Pasquale Perrone-Filardi & Stefania Paolillo

  3. Istituto Diagnostico Varelli, Naples, Italy

    Caterina Marciano

  4. Division of Cardiology, Ospedale Accreditato Villa dei Fiori, Acerra, Naples, Italy

    Santo Dellegrottaglie

  5. Mediterranea Cardiocentro, Naples, Italy

    Stefania Paolillo

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  1. Paola Gargiulo
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Correspondence to Pasquale Perrone-Filardi.

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Gargiulo, P., Marsico, F., Renga, F. et al. The metabolic syndrome in heart failure: insights to specific mechanisms. Heart Fail Rev 25, 1–7 (2020). https://doi.org/10.1007/s10741-019-09838-6

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