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The cell cycle associated protein, HTm4, is expressed in differentiating cellsof the hematopoietic and central nervous system in mice

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Abstract

HTm4 is a member of a newly defined family of human and murine proteins, the MS4 (membrane-spanning four) protein group, which has a distinctive four-transmembrane structure. MS4 protein functions include roles as cell surface signaling receptors and intracellular adapter proteins. We have previously demonstrated that HTm4 regulates the function of the KAP phosphatase, a key regulator of cell cycle progression. In humans, the expression of HTm4 is largely restricted to cells of the hematopoietic lineage, possibly reflecting a causal role for this molecule in differentiation/proliferation of hematopoietic lineage cells. In this study, we show that, like the human homologue, murine HTm4 is also predominantly a hematopoietic protein with distinctive expression patterns in developing murine embryos and in adult animals. In addition, we observed that murine HTm4 is highly expressed in the developing and adult murine nervous system, suggesting a previously unrecognized role in central and peripheral nervous system development.

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Authors and Affiliations

  1. Department of Pathology, Brigham and Women,s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Jeffery L. Kutok & Rebecca D. Folkerth

  2. Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA

    Xing Yang, Yoshihiko Yano, Saira Salahuddin, Joel Lawitts & Chaker Adra

  3. Center For Neurological Diseases, Brigham and Women,s Hospital, Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA

    Jaime Imitola, Khadir Raddassi & Samia Khoury

  4. Division of Neurobiology, University of Bern, Baltzerstrasse 4, CH, 3012, Bern, Switzerland

    Hans Imboden

  5. Department of Nutrition, Kyushu Women,s University, Jiyugaoka 1-1, kitakyushushi, 807-8586, Japan

    Masanobu Chinami

  6. Department of Health Promotion & Human Behavior, Kyoto University Graduate School of Public Health, Kyoto, 606-8501, Japan

    Taro Shirakawa

  7. RIKEN SNP Typing Center, Shirokanedai 4-6-1, Tokyo, 108-8639, Japan

    Taro Shirakawa

  8. Laboratory of Cell Biology and Immunology, The Queens Medical Center, Honolulu, HI

    Helen Turner

  9. Laboratory of Immunogenetics & Transplantation, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Mohamed H. Sayegh

  10. Department of Medicine, Children Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Mohamed H. Sayegh & Chaker Adra

  11. Experimental Hematology, AIDS Research Center, Massachusetts General Hospital, Boston, MA, 02129, USA

    David Scadden

Authors
  1. Jeffery L. Kutok
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  2. Xing Yang
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  9. Hans Imboden
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  10. Masanobu Chinami
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  11. Taro Shirakawa
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  12. Helen Turner
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  13. Samia Khoury
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  14. Mohamed H. Sayegh
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  16. Chaker Adra
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Corresponding author

Correspondence to Chaker Adra.

Additional information

JLK and XY contributed equally to this work

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Kutok, J.L., Yang, X., Folkerth, R.D. et al. The cell cycle associated protein, HTm4, is expressed in differentiating cellsof the hematopoietic and central nervous system in mice. J Mol Hist 36, 77–87 (2005). https://doi.org/10.1007/s10735-004-3913-8

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  • DOI: https://doi.org/10.1007/s10735-004-3913-8

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