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The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate

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Abstract

The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These interactions involve internal oligosaccharide sequences defined by their sulfation patterns. Amongst these, the 6-O-sulfation of HS contributes significantly to the polysaccharide structural diversity and is critically involved in the binding of many proteins. HS 6-O-sulfation is catalyzed by 6-O-sulfotransferases (6OSTs) during biosynthesis, and it is further modified by the post-synthetic action of 6-O-endosulfatases (Sulfs), two enzyme families that remain poorly characterized. The aim of the present review is to summarize the contribution of 6-O-sulfates in HS structure/function relationships and to discuss the present knowledge on the complex mechanisms regulating HS 6-O-sulfation.

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Acknowledgments

This work is supported by grants from the Agence Nationale de la Recherche (ANR-12-SVSE-008) and Université Grenoble-Alpes (UGA AGIR program).

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  1. University Grenoble Alpes, IBS, F-38044, Grenoble, France

    Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob & Romain R. Vivès

  2. CNRS, IBS, F-38044, Grenoble, France

    Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob & Romain R. Vivès

  3. CEA, IBS, F-38044, Grenoble, France

    Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob & Romain R. Vivès

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  1. Rana El Masri
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El Masri, R., Seffouh, A., Lortat-Jacob, H. et al. The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate. Glycoconj J 34, 285–298 (2017). https://doi.org/10.1007/s10719-016-9736-5

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