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Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count

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Abstract

Sulfatide is a major component of glycosphingolipids in lipoproteins. Recently, we reported that a low serum level of sulfatide in hemodialysis patients might be related to the high incidence of cardiovascular diseases. However, the serum kinetics of sulfatide in kidney disease patients and the function of endogenous serum sulfatide are still unclear. To obtain novel knowledge concerning these issues, we investigated the serum kinetics of sulfatide in 5 adult kidney transplant recipients. We also analyzed the correlated factors influencing the serum sulfatide level, using multiple regression analysis. Kidney transplantation caused a dramatic increase of serum sulfatide without an alteration of its composition in all recipients in a time-dependent manner; however, the recovery speed was slower than that of the improvement of kidney function and the serum sulfatide reached a nearly normal level after 1 year. Multiple regression analysis showed that the significant correlated factor influencing the serum sulfatide level was log duration (time parameter) throughout the observation period, and the correlated factors detected in the stable phase were the decrease of serum concentration of malondialdehyde (an oxidative stress marker) as well as the elevation of platelet count. The current study results demonstrated the gradual but reliable recovery of the serum sulfatide level in kidney transplant recipients for the first time, suggesting a close correlation between serum sulfatide and kidney function. The recovery of serum sulfatide might derive from the attenuation of systemic oxidative stress. The normal level of serum sulfatide in kidney transplant recipients might affect platelet function, and contribute to the reduction of cardiovascular disease incidence.

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Abbreviations

AKI:

Acute kidney injury

CST:

Cerebroside sulfotransferase

CVD:

Cardiovascular disease

ESRD:

End-stage renal disease

GP:

Glycoproteins

HD:

Hemodialysis therapy

LS:

Lysosulfatide

d18:2:

Sphingadienine

d18:1:

(4E)-sphingenine

d18:0:

Sphinganine

t18:0:

Phytosphingosine

d20:1:

(4E)-icosasphingenine

d20:0:

Icosasphinganine

t20:0:

4D-hydroxyicosasphinganine

MALDI-TOF MS:

Matrix-assisted laser desorption ionization-time of flight mass spectrometry

MDA:

Malondialdehyde

PD:

Peritoneal dialysis therapy

SD:

Standard deviation

vWF:

Von Willebrand factor

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Acknowledgment

This work was supported in part by GL Sciences (Tokyo, Japan) and Shinshu Public Utility Foundation for the Promotion of Medical Sciences (Matsumoto, Japan).

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Authors and Affiliations

  1. Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Lixuan Wang, Yuji Kamijo, Takero Nakajima, Toshifumi Aoyama & Atsushi Hara

  2. Department of Histology and Embryology, Hebei Medical University, 361 Zhong Shan East Road, Shijiazhuang, Hebei, 050017, China

    Lixuan Wang

  3. Department of Nephrology Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Yuji Kamijo & Makoto Higuchi

  4. Department of Hepatology Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Akihiro Matsumoto

  5. Research Complex for the Medicine Frontiers, Aichi Medical University, 21 Karimata, Yazako, Nagakute, Aichi, 480-1195, Japan

    Reiji Kannagi

  6. Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Mamoru Kyogashima

  7. Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan

    Mamoru Kyogashima

Authors
  1. Lixuan Wang
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  2. Yuji Kamijo
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  3. Akihiro Matsumoto
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  4. Takero Nakajima
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  5. Makoto Higuchi
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  6. Reiji Kannagi
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  7. Mamoru Kyogashima
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  8. Toshifumi Aoyama
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  9. Atsushi Hara
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Corresponding author

Correspondence to Yuji Kamijo.

Additional information

Lixuan Wang and Yuji Kamijo contributed equally to this work.

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Wang, L., Kamijo, Y., Matsumoto, A. et al. Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count. Glycoconj J 28, 125–135 (2011). https://doi.org/10.1007/s10719-011-9329-2

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  • DOI: https://doi.org/10.1007/s10719-011-9329-2

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