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Gene mapping in the wild with SNPs: guidelines and future directions

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An Erratum to this article was published on 04 March 2010

Abstract

One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.

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Acknowledgements

This article was prepared for a workshop on Ecological Genomics that was organised by Jacob Höglund and Gernot Segelbacher, and funded by the European Science Foundation (ESF). The authors have benefitted from insightful discussion on this and related topics with Terry Burke, Peter Visscher, Gavin Hinten and Allan McRae. Peter Visscher made the suggestion to study the variance in halfsib IBD coefficients as an indicator of marker informativeness.

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  1. Matt Hale

    Present address: Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana, 47907-1159, USA

Authors and Affiliations

  1. Department of Animal & Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK

    Jon Slate, Jake Gratten, Jessica Stapley & Matt Hale

  2. Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK

    Dario Beraldi & Josephine M. Pemberton

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  1. Jon Slate
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Correspondence to Jon Slate.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10709-010-9445-0

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Slate, J., Gratten, J., Beraldi, D. et al. Gene mapping in the wild with SNPs: guidelines and future directions. Genetica 136, 97–107 (2009). https://doi.org/10.1007/s10709-008-9317-z

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