Skip to main content
SpringerLink
Log in

A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han

  • Published:
Familial Cancer Aims and scope Submit manuscript

Abstract

MicroRNAs are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. A G>C polymorphism (rs2910164), which is located in the sequence of miR-146a precursor, results in a change from G:U to C:U in its stem region. However, it remains largely unknown whether this single nucleotide polymorphism (SNP) may alter esophageal squamous cell carcinoma (ESCC) susceptibility. In the current study, we evaluated association between rs2910164 and ESCC susceptibility in a case–control study of 444 sporadic ESCC patients and 468 matched cancer-free controls in a Chinese Han population. Compared with rs2910164 variant genotype CC, genotype GG was associated with increased risk of ESCC (Odds Ratio, 2.39, 95% Confidence Interval, 1.36–4.20). In the smokers, the risk of rs2910164 GG genotype was more notable (Odds Ratio, 3.17, 95% Confidence Interval, 1.71–4.46). In the stratification analyses, we also found there was a strong correlation between rs2910164 C/G variant and the clinical TNM stage (P < 0.01). These findings suggest that this functional SNP in pre-miR-146a could contribute to ESCC susceptibility and clinical outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ESCC:

Esophageal squamous cell carcinoma

miRNA:

MicroRNA

SNP:

Single nucleotide polymorphism

References

  1. Kamangar F, Dores GM, Anderson WF (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24:2137–2150

    Article  PubMed  Google Scholar 

  2. Pickens A, Orringer MB (2003) Geographical distribution and racial disparity in esophageal cancer. Ann Thorac Surg 76:S1367–S1369

    Article  PubMed  Google Scholar 

  3. Enzinger PC, Mayer RJ (2004) Esophageal cancer. N Engl J Med 349:2241–2252

    Article  Google Scholar 

  4. Bartel DP, Chen CZ (2004) Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5:396–400

    Article  CAS  PubMed  Google Scholar 

  5. Shen J, Ambrosone CB, DiCioccio RA et al (2008) A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis 29:1963–1966

    Article  CAS  PubMed  Google Scholar 

  6. Jazdzewski K, Murray EL, Franssila K et al (2008) Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 105:7269–7274

    Article  CAS  PubMed  Google Scholar 

  7. Xu B, Feng NH, Li PC et al (2010) A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. Prostate 70:467–472

    Article  CAS  PubMed  Google Scholar 

  8. Xu T, Zhu Y, Wei QK et al (2008) A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis 29:2126–2131

    Article  CAS  PubMed  Google Scholar 

  9. Hu Z, Liang J, Wang Z et al (2009) Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat 30:79–84

    Article  CAS  PubMed  Google Scholar 

  10. Tian T, Shu Y, Chen J et al (2009) A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese. Cancer Epidemiol Biomarkers Prev 18:1183–1187

    Article  CAS  PubMed  Google Scholar 

  11. Volinia S, Calin GA, Liu CG et al (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257–2261

    Article  CAS  PubMed  Google Scholar 

  12. Guo Y, Chen Z, Zhang L et al (2008) Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma. Cancer Res 68:26–33

    Article  CAS  PubMed  Google Scholar 

  13. Taganov KD, Boldin MP, Chang KJ et al (2006) NF-kappaB-dependent induction of microRNA mir-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103:12481–12486

    Article  CAS  PubMed  Google Scholar 

  14. Jazdzewski K, Liyanarachchi S, Swierniak M et al (2009) Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. Proc Natl Acad Sci USA 106:1502–1505

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 30872549 and No. 30971603) and Natural Science Foundation Project of CQ CSTC (No. 2009BA5013).

Conflict of interest

We declare that there is no Conflict of interest.

Author information

Authors and Affiliations

  1. Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, 400038, Chongqing, People’s Republic of China

    Hong Guo, Kai Wang, Huamei Hu, Dongmei Wang, Xueqing Xu, Xingying Guan & Yun Bai

  2. Department of Thoracic and Cardiac Surgery, Southwest Hospital, Third Military Medical University, 400038, Chongqing, People’s Republic of China

    Gang Xiong & Kang Yang

Authors
  1. Hong Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kai Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gang Xiong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Huamei Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dongmei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xueqing Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xingying Guan
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kang Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yun Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Kang Yang or Yun Bai.

Additional information

Hong Guo and Kai Wang contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guo, H., Wang, K., Xiong, G. et al. A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han. Familial Cancer 9, 599–603 (2010). https://doi.org/10.1007/s10689-010-9370-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10689-010-9370-5

Keywords

Search

Navigation