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BRCA1 and BRCA2 Mutations in Breast and Ovarian Cancer Syndrome: Reflection on the Creighton University Historical Series of High Risk Families

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Abstract

Over the last four decades, Henry Lynch has collected pedigrees and samples from high risk breast and/or ovarian cancer families, generating a unique resource for the study of breast cancer susceptibility. These families have made a major contribution to increasing our knowledge in the cancer genetic susceptibility field, allowing the discovery of a genetic association between breast and ovarian cancer predisposition, contributing to the mapping of the BRCA1 and BRCA2 genes, advancing the idea of the existence of other breast cancer susceptibility genes, allowing the evaluation of BRCA-associated cancer risks and psychosocial aspects of BRCA testing and so on. Ten years after the cloning of BRCA1 and BRCA2, we report the current status of these families and compare the observed BRCA1/2 mutation detection rate with the estimations obtained by linkage analysis of the Breast Cancer Linkage Consortium families.

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Authors and Affiliations

  1. Plate-forme Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, Lyon cedex 08, 69373, France

    Olga M. Sinilnikova

  2. Laboratoire de Génétique Moléculaire, Signalisation et Cancer UMR5201 CNRS, Université Claude Bernard Lyon I, Lyon cedex 08, 69373 , France

    Sylvie Mazoyer

  3. International Agency for Research on Cancer, Lyon cedex 08, 69372, France

    Colette Bonnardel

  4. Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, USA

    Henry T. Lynch

  5. The Centre for Research in Women’s Health, Sunnybrook and Women’s College Health Sciences Centre, Toronto, ON, Canada

    Steven A. Narod

  6. Laboratoire de Génétique Oncologique, UMR CNRS 8125, Institut Gustave-Roussy, 94805, Villejuif, France

    Gilbert M. Lenoir

  7. Bâtiment Cheney B, Centre Léon Bérard, 28, rue Laënnec, 69373, Lyon cedex 08, France

    Olga M. Sinilnikova

Authors
  1. Olga M. Sinilnikova
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  2. Sylvie Mazoyer
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  3. Colette Bonnardel
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  4. Henry T. Lynch
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  5. Steven A. Narod
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  6. Gilbert M. Lenoir
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Corresponding author

Correspondence to Olga M. Sinilnikova.

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Sinilnikova, O.M., Mazoyer, S., Bonnardel, C. et al. BRCA1 and BRCA2 Mutations in Breast and Ovarian Cancer Syndrome: Reflection on the Creighton University Historical Series of High Risk Families. Familial Cancer 5, 15–20 (2006). https://doi.org/10.1007/s10689-005-2571-7

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  • DOI: https://doi.org/10.1007/s10689-005-2571-7

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