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Analysis of cadmium, nickel, and lead in commercial moist and dry snuff used in Pakistan

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Abstract

The extent to which smokeless tobacco endangers human health is an ongoing subject of debate. In this study, concentrations of toxic metals, cadmium (Cd), lead (Pb), and nickel (Ni), were measured in different snuff products (dry brown and black and moist green and brown), available and consumed in Pakistan. Concentrations of Cd, Pb, and Ni were determined in 23 samples of various brands of snuff by electrothermal atomic absorption spectrometry, after microwave-assisted acid digestion. The reliability of methodology was assured by analyzing certified reference material. The resulted data of toxic metals in different snuff products are comparable to the existing information with limited exceptions. It was estimated that 10 g intake of different types of snuff could contribute 14–68, 17–47, and 20–73 % of the provisional maximum tolerable daily intake for Cd, Ni, and Pb, respectively.

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References

  • Addo, M. A., Gbadago, J. K., Affum, H. A., Adom, T., Ahmed, K., & Okley, G. M. (2008). Mineral profile of Ghanaian dried tobacco leaves and local snuff: a comparative study. Journal of Radioanalytical and Nuclear Chemistry, 277, 517–524.

    Article  CAS  Google Scholar 

  • Altundag, H., & Tuzen, M. (2011). Comparison of dry, wet and microwave digestion methods for the multi element, determination in some dried fruit samples by ICP-OES. Food and Chemical Toxicology, 49, 2800–2807.

    Article  CAS  Google Scholar 

  • Arain, M. B., Kazi, T. G., Jamali, M. K., Jalbani, N., Afridi, H. I., Kandhro, G. A., et al. (2008). Hazardous impact of toxic metals on tobacco leaves grown in contaminated soil by ultrasonic assisted pseudo-digestion: multivariate study. Journal of Hazardous Material, 155, 216–224.

    Article  CAS  Google Scholar 

  • Asta, J., Guillard, E., Tissut, M., Gaude, T., & Ravanel, P. (2003). Heavy metal transfer from atmosphere to plants. Journal of Physics, 107, 65–67.

    CAS  Google Scholar 

  • Baars, R. J., Theelen, R. M. C., Janssen, P. J. C. M., Hesse, J. M., Apeldoorn, M. E., Van Meijerink, M. C. M., et al. (2001). Re-evaluation of human-toxicological maximum permissible risk levels. Bilthoven: National Institute for Public Health and the Environment.

    Google Scholar 

  • Bhupander, K., & Mukherjee, D. P. (2011). Assessment of human health risk for arsenic, copper, nickel, mercury and zinc in fish collected from tropical wetlands in India. Advances in Life Science and Technology, 2, 13–24.

    Google Scholar 

  • Bolinder, G. (1997). Overview of knowledge of health effects of smokeless tobacco. Increased risk of cardiovascular diseases and mortality because of snuff. Loekartidningen, 94, 3725–3731.

    CAS  Google Scholar 

  • Bouquot, J. E. (1991). Reviewing oral leukoplakia. Clinical concepts for the 1990s. Journal of the American Dental Association, 122, 80–82.

    CAS  Google Scholar 

  • CDC. (2000). Tobacco use among middle and high school students—United States. Centers for Disease Control and Prevention, 1999, 300–303.

    Google Scholar 

  • CDC. (2005). Tobacco use, access, and exposure to tobacco in media among middle and high school students—United States. Centers for Disease Control and Prevention, 2004, 297–301.

    Google Scholar 

  • Colak, H., Soylak, M., & Turkoglu, O. (2005). Determination of trace metal content of various herbal and fruit teas produced and marketed from Turkey. Trace Elements and Electrolytes, 22, 192–195.

    CAS  Google Scholar 

  • Demirel, S., Tuzen, M., Saracoglu, S., & Soylak, M. (2008). Evaluation of various digestion procedures for trace element contents of some food materials. Journal of Hazardous Materials, 152, 1020–1026.

    Article  CAS  Google Scholar 

  • Dhaware, D., Deshpande, A., Khandekar, R. N., & Chowgule, R. (2009). Determination of toxic metals in Indian smokeless tobacco products. The Scientific World Journal, 9, 1140–1147.

    Article  CAS  Google Scholar 

  • FAO/WHO (1989). Expert Committee on Food Additives: toxicological evaluation of certain food additives and contaminants. 33rd Meeting of the Joint FAO/WHO. Ser. 24. World Health Organization, Geneva.

  • FAO/WHO (1993). Expert Committee on Food Additives: evaluation of certain food additives and contaminants. 41st Meeting of the Joint FAO/WHO. Ser. 837. World Health Organization, Geneva.

  • FTC (2001). Report to Congress for the years 1998 and 1999, Federal Trade Commission.

  • FTC. (2003). FTC report to congress shows increases in smokeless tobacco revenues and advertising and promotional expenditures. Washington, DC: Federal Trade Commission.

    Google Scholar 

  • Hecht, S. S., & Hoffmann, D. (1988). Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis, 9, 875–884.

    Article  CAS  Google Scholar 

  • IARC. (1985). Tobacco habits other than smoking: betel-quid and areca-nut chewing; and some related nitrosamines. Lyon: International Agency for Research on Cancer.

    Google Scholar 

  • IARC. (2006a). Monographs on the overall evaluations of carcinogenicity to humans (pp. 1–95). Lyon: International Agency for Research on Cancer.

    Google Scholar 

  • IARC. (2006b). Monographs on the evaluation of carcinogenic risks to humans, inorganic and organic lead compounds (p. 87). Lyon: International Agency for Research on Cancer.

    Google Scholar 

  • Substance Abuse and Mental Health Services Administration (2006). Results from the 2005 National Survey on Drug Use and Health: Detailed Tables. Office of Applied Studies.

  • Miccadei, S., & Floridi, A. (1993). Sites of inhibition of mitochondrial electron transport by cadmium. Chemico-biological interactions, 89, 156–167.

    Article  Google Scholar 

  • Mishra, U. C., & Shaikh, G. N. (1986). Simultaneous multielement determination of chewing and snuff tobaccos used in India by INAA. Journal of Radioanalytical and Nuclear Chemistry, 98, 297–301.

    Article  CAS  Google Scholar 

  • Muir, C. S., & Zaridze, D. G. (1986). Smokeless tobacco and cancer: an overview. In: Tobacco a major international health hazard. International Agency for Research on Cancer Scientific Publication, 74, 35–44.

  • Narin, I., & Soylak, M. (1999). Monitoring trace metal levels in Nigde, Turkey: nickel, copper, manganese, cadmium and cobalt contents of the street dust samples. Trace Elements and Electrolytes, 16, 99–103.

    CAS  Google Scholar 

  • National Institute of Public Health (2000). 11th World Conference on Tobacco or Health.

  • Pappas, R. S., Stanfill, S. B., Watson, C. H., & Ashley, D. L. (2008). Analysis of toxic metals in commercial moist snuff and Alaskan Iqmik. Journal of Analytical Toxicology, 32, 281–291.

    Article  CAS  Google Scholar 

  • Saracoglu, S., Tuzen, M., & Soylak, M. (2009). Evaluation of trace element contents of dried apricot samples from Turkey. Journal of Hazardous Materials, 167, 647–652.

    Article  CAS  Google Scholar 

  • Schildt, E. B., Eriksson, M., Hardell, L., & Magnuson, A. (1998). Oral snuff, smoking habits and alcohol consumption in relation to oral cancer in a Swedish case-control study. International Journal of Cancer, 77, 341–346.

    Article  CAS  Google Scholar 

  • Schroeder, K. L., & Chen, M. S., Jr. (1985). Smokeless tobacco and blood pressure. New England Journal of Medicine, 312, 919.

    CAS  Google Scholar 

  • Sesli, E., Tuzen, M., & Soylak, M. (2008). Evaluation of trace metal contents of some wild edible mushrooms from Black sea region, Turkey. Journal of Hazardous Materials, 160, 462–467.

    Article  CAS  Google Scholar 

  • Shaikh, A. N., Negi, B. S., & Sadasivan, S. (2002). Characterization of Indian cigarette tobacco and its smoke aerosol by nuclear and allied techniques. Journal of Radioanalytical and Nuclear Chemistry, 253, 231–234.

    Article  CAS  Google Scholar 

  • Silici, S., Uluozlu, O. D., Tuzen, M., & Soylak, M. (2008). Assessment of trace element levels in Rhododendron honeys of Black Sea Region, Turkey. Journal of Hazardous Materials, 156, 612–618.

    Article  CAS  Google Scholar 

  • Soylak, M., Elci, L., & Dogan, M. (1993). Determination of some trace metals in dialysis solutions by atomic absorption spectrometry after preconcentration. Analytical Letters, 26, 1997–2007.

    Article  CAS  Google Scholar 

  • Soylak, M., Tuzen, M., Souza, A. S., Korn, M. G. A., & Ferreira, S. L. C. (2007). Optimization of microwave assisted digestion procedure for the determination of zinc, copper and nickel in tea samples employing flame atomic absorption spectrometry. Journal of Hazardous Materials, 149, 264–268.

    Article  CAS  Google Scholar 

  • Stepanov, I., & Hecht, S. S. (2005). Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users. Cancer Epidemiology Biomarkers and Prevention, 14, 885–891.

    Article  CAS  Google Scholar 

  • Stohs, S. J., & Bagchi, D. (1995). Oxidative mechanisms in the toxicity of metal ions. Free radical biology and medicine, 18, 321–336.

    Article  CAS  Google Scholar 

  • Uluozlu, O. D., Tuzen, M., Mendil, D., & Soylak, M. (2009). Assessment of trace element contents of chicken products from turkey. Journal of Hazardous Materials, 163, 982–987.

    Article  CAS  Google Scholar 

  • US Department of Health and Human Services (1986). Health consequences of using smokeless tobacco: a report of the Advisory Committee to the Surgeon General. Bethesda, Maryland.

  • Verma, S., Yadav, S., & Singh, I. (2010). Trace metal concentration in different Indian tobacco products and related health implications. Food and Chemical Toxicology, 48, 2291–2297.

    Article  CAS  Google Scholar 

  • Verougstraete, V., Lison, D., & Hotz, P. (2003). Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data. Journal of Toxicology and Environmental Health, Part B: Critical Review, 6, 227–255.

    Article  CAS  Google Scholar 

  • Vijayan, V. K., & Kumar, R. (2005). Tobacco cessation in India. The Indian Journal of Chest Disease and Allied Sciences, 47, 5–8.

    CAS  Google Scholar 

  • WHO. (1988). Smokeless tobacco control. Geneva: World Health Organization.

    Google Scholar 

  • WHO (1989). Toxicological evaluations of certain food additives and contaminants: arsenic. 33 Report of the JEFCA, World Health Organization WHO food additive series.

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Correspondence to Sadaf Sadia Arain.

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Kazi, T.G., Arain, S.S., Afridi, H.I. et al. Analysis of cadmium, nickel, and lead in commercial moist and dry snuff used in Pakistan. Environ Monit Assess 185, 5199–5208 (2013). https://doi.org/10.1007/s10661-012-2936-y

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  • DOI: https://doi.org/10.1007/s10661-012-2936-y

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