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Adult height and risk of ischemic heart disease, atrial fibrillation, stroke, venous thromboembolism, and premature death: a population based 36-year follow-up study

  • CARDIOVASCULAR DISEASE
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Abstract

Few studies have associated height with cardiovascular diseases other than myocardial infarction. We conducted a population-based 36-year cohort study of 12,859 men born in 1955 or 1965 whose fitness for military service was assessed by Draft Boards in Northern Denmark. Hospital diagnoses for ischemic heart diseases, atrial fibrillation, stroke, and venous thromboembolism were obtained from the Danish National Patient Registry, covering all Danish hospitals since 1977. Mortality data were obtained from the Danish Civil Registration System. We began follow-up on the 22nd birthday of each subject and continued until occurrence of an outcome, emigration, death, or 31 December 2012, whichever came first. We used Cox regression to compute hazard ratios (HRs) with 95 % confidence intervals (CIs). Compared with short stature, the education-adjusted HR among tall men was 0.67 (95 % CI 0.54–0.84) for ischemic heart disease (similar for myocardial infarction, angina pectoris, and heart failure), 1.60 (95 % CI 1.11–2.33) for atrial fibrillation, 1.05 (95 % CI 0.75–1.46) for stroke, 1.04 (95 % CI 0.67–1.64) for venous thromboembolism, and 0.70 (95 % CI 0.58–0.86) for death. In conclusion, short stature was a risk factor for ischemic heart disease and premature death, but a protective factor for atrial fibrillation. Stature was not substantially associated with stroke or venous thromboembolism.

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Acknowledgments

The study was supported by Aarhus University, the Danish Research Council (grants 11-108354 and 11-115818), “Augustinusfonden”, and the Clinical Epidemiological Research Foundation, Denmark. These funding sources had no role in the design, conduct, analysis, or reporting of this study. The Department of Clinical Epidemiology, Aarhus University Hospital, receives funding for other studies from companies in the form of research grants to (and administered by) Aarhus University. None of the company-funded studies have any relation to the present study.

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Ethical standard

As this study did not involve any patients or any intervention, it was not necessary to obtain permission from the Danish Scientific Ethical Committee.

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Authors and Affiliations

  1. Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus, Denmark

    Morten Schmidt, Lars Pedersen & Henrik Toft Sørensen

  2. Department of Cardiology, Aarhus University Hospital, Skejby, Denmark

    Morten Schmidt & Hans Erik Bøtker

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  1. Morten Schmidt
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Correspondence to Morten Schmidt.

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Schmidt, M., Bøtker, H.E., Pedersen, L. et al. Adult height and risk of ischemic heart disease, atrial fibrillation, stroke, venous thromboembolism, and premature death: a population based 36-year follow-up study. Eur J Epidemiol 29, 111–118 (2014). https://doi.org/10.1007/s10654-013-9867-y

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